Dermatoses of chronic nature: new developments in diagnosis and treatment

Introduction: Chronic dermatoses significantly affect patients’ lives, and global burden of skin diseases represents important public health challenge worldwide, with the phenomenon of a tendency towards increasing level of dermatological pathology. Methods: In the last two decades, there has been a significant breakthrough in improving methods and strategies for treating chronic dermatoses, with the emergence of relevant innovative technologies and drugs. At the same time, publications describing these innovations are scattered and narrowly focused, often lacking a systemic vision. Results: With this in mind, the article aims at outlining the overall (integrative) landscape of contemporary paradigms, vision and approaches to the diagnosis and treatment of chronic dermatoses of various specifics and etiology. Based on the tools of scoping review, as well as general scientific methods of systematization and generalization, existing achievements and challenges in diagnosing and treatment of skin diseases such as atopic dermatitis, psoriasis, eczema, etc. were revealed and put together. Conclusions: The findings demonstrate that, despite significant and evident, sometimes disruptive, advances in skin diseases diagnosis and treatment, such as AI and machine learning in diagnosis and biologic drugs in treatment (allowing customizing treatment to target specific immune pathways), there are still remaining challenges, which represent crucial frontiers for future research.