Endocrine Disorders Associated with Obesity: Cushing's syndrome and Hypothyroidism

Obesity has been related to a wide range of endocrine disorders, from common ones including ovarian syndrome and hypothyroidism to unusual ones like Cushing's syndrome (CS), hypothyroidism, and hypothalamic abnormalities. Obesity can arise via a variety of endocrine disorders using several mechanisms. Multiple tissues accumulate hyaluronic acid, which causes greater fluid retention as a result of reduced thermogenesis and lower cardiac output, both of which are signs of hypothyroidism. The pathophysiology of obesity in polycystic ovarian syndrome is the unclear since it's possible that obesity both contributes to and harms polycystic ovarian syndrome. Net androgen excess seems to have a significant impact on the development of central adiposity. The interaction between thyroid and growth hormones, together with increased adipocyte differentiation and adiposity, is important in Cushing's illness. Additional peculiar situations are also examined in the research, such as hypothalamic obesity brought on by a concomitant hormonal deficiency and central hypothyroidism.