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Visual disturbances due to semaglutide: A systematic review of the literature

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  • Camila Barreto Maciel

    (Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud, Carrera de Medicina. Ciudad Autónoma de Buenos Aires, Argentina)

  • Marcelo Adrian Estrin

    (Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud, Carrera de Medicina. Ciudad Autónoma de Buenos Aires, Argentina)

Abstract

Introduction: Semaglutide is a widely used medication for the management of type 2 diabetes and, more recently, for the treatment of obesity. While it is known for its efficacy in controlling glycemia and promoting weight loss, side effects have also been reported, including some related to vision. These side effects are uncommon but may be indirectly linked. Objectives: This study aimed to analyze the available evidence on visual disturbances associated with the use of semaglutide, describing the possible pathophysiological mechanisms involved and its clinical impact on patients. Materials and methods: A systematic review of the literature was conducted in scientific databases such as PubMed, Medscape, Scopus, and Cochrane, evaluating the incidence, severity, and reversibility of these adverse effects. Results: Several studies that demonstrated the ophthalmological risk associated with the use of semaglutide were selected. Conclusion: Although semaglutide has several proven benefits as a medication for type 2 diabetes, its use poses some risks that should be actively investigated, primarily the ophthalmological risks associated with semaglutide, especially in patients with a history of eye disease.

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Handle: RePEc:cwh:ijneur:v:59:y:2025:id:247
DOI: 10.62486/ijn2025247
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