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Impact of the use of botulinium toxin type A in the current treatment off chronic migraine in adults

Author

Listed:
  • Tiago Goulart Appel

    (Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud. Carrera de Medicina, Argentina)

  • João Francisco De Oliveira Neto

    (Universidad Abierta Interamericana, Facultad de Medicina y Ciencias de la Salud. Carrera de Medicina, Argentina)

Abstract

Introduction: Migraine is a complex neurological disorder that causes recurrent, localized headaches and is associated with hyperstimulation of the muscles in the frontal, temporal, occipital, and trapezius regions. Botulinum toxin acts on the motor plate by blocking the action of acetylcholine, thereby producing an analgesic effect in these patients. Materials and methods: A systematic review will be conducted using the PubMed and Scielo electronic databases. The search criteria were studies and reviews published between 2014 and April 2020 to identify transitional research focused on the use of botulinum toxin in patients with chronic migraine. Results: Nine articles that met the criteria for evaluating the efficacy of chronic migraine treatment using Onabotulimumtoxin A were included. An average of three cycles of the PREEMPT treatment protocol were performed. The mean age was 47 years, and 82.5% were women. The frequency of headache days/month and its intensity were significantly reduced by 30 to 50%, and this improvement was maintained over time. Conclusion: Randomized studies have shown that long-term, fixed-dose, fixed-site intramuscular injection therapy with botulinum toxin A is a safe and effective procedure with insignificant complications in appropriately selected patients.

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Handle: RePEc:cwh:ijneur:v:57:y:2023:id:54
DOI: 10.62486/ijn202354
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