Full Issue

The combined issue (Numbers 2–3) of Volume 11 of the International Journal of Neurology (1977) was dedicated to regional cerebral blood flow. It opened with editorials in Spanish and English and presented a series of landmark contributions that established the methodological and physiological foundations for modern cerebral hemodynamics research. The volume featured authoritative papers on the measurement of regional cerebral blood flow (rCBF) (Ingvar and Lassen), and on the link between cerebral perfusion and neurological function in humans (Ingvar). W. D. Heiss contributed two detailed studies on rCBF measurement using scintillation camera techniques, while Takenori Yamaguchi analyzed experimental cerebral infarction with emphasis on post-ischemic hyperemia. Methodological advances included the Xenon-133 inhalation method (Merory, McHenry, and Toole) and the use of gamma camera imaging for neurological diagnosis (Mathew, Hartmann, and Meyer). Additional diagnostic approaches were explored through ultrasonic detection of cerebrovascular lesions (Büdingen, Von Reutern, and Freund) and Doppler ultrasonic imaging for non-invasive cerebrovascular evaluation (Spencer). Further studies addressed the role of carbonic anhydrase in the autoregulation of cerebral circulation (Gotoh and Shinohara) and ionic actions on cerebral vessels (Betz and Csornai). Complementary sections included Histoire de la Médecine by Madame Legée Georgette and an article on teaching neurology in Germany (Janzen), followed by book reviews and news. This issue represented a milestone in the journal’s history, integrating experimental physiology, imaging innovation, and clinical neurology to advance the understanding of cerebral perfusion and its role in brain function and disease.