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Of Mice and Academics: Examining the Effect of Openness on Innovation

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  • Fiona Murray
  • Philippe Aghion
  • Mathias Dewatripont
  • Julian Kolev
  • Scott Stern

Abstract

Scientific freedom and openness are hallmarks of academia: relative to their counterparts in industry, academics maintain discretion over their research agenda and allow others to build on their discoveries. This paper examines the relationship between openness and freedom, building on recent models emphasizing that, from an economic perspective, freedom is the granting of control rights to researchers. Within this framework, openness of upstream research does not simply encourage higher levels of downstream exploitation. It also raises the incentives for additional upstream research by encouraging the establishment of entirely new research directions. In other words, within academia, restrictions on scientific openness (such as those created by formal intellectual property (IP)) may limit the diversity and experimentation of basic research itself. We test this hypothesis by examining a "natural experiment" in openness within the academic community: NIH agreements during the late 1990s that circumscribed IP restrictions for academics regarding certain genetically engineered mice. Using a sample of engineered mice that are linked to specific scientific papers (some affected by the NIH agreements and some not), we implement a differences-in-differences estimator to evaluate how the level and type of follow-on research using these mice changes after the NIH-induced increase in openness. We find a significant increase in the level of follow-on research. Moreover, this increase is driven by a substantial increase in the rate of exploration of more diverse research paths. Overall, our findings highlight a neglected cost of IP: reductions in the diversity of experimentation that follows from a single idea.

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Bibliographic Info

Paper provided by National Bureau of Economic Research, Inc in its series NBER Working Papers with number 14819.

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Date of creation: Mar 2009
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Handle: RePEc:nbr:nberwo:14819

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  1. Owen-Smith, Jason & Powell, Walter W., 2003. "The expanding role of university patenting in the life sciences: assessing the importance of experience and connectivity," Research Policy, Elsevier, vol. 32(9), pages 1695-1711, October.
  2. Murray, Fiona & Stern, Scott, 2007. "Do formal intellectual property rights hinder the free flow of scientific knowledge?: An empirical test of the anti-commons hypothesis," Journal of Economic Behavior & Organization, Elsevier, vol. 63(4), pages 648-687, August.
  3. Henderson, R. & Jaffe, A.B.: Tratenberg, M., 1995. "Universities as a Source of Commercial Technology: A Detailed Analysis of University Patenting 1965-1988," Papers 09-95, Tel Aviv.
  4. Fiona E. Murray & Scott Stern, 2007. "Do Formal Intellectual Property Rights Hinder the Free Flow of Scientific Knowledge?: An Empirical Test of the Anti-Commons Hypothesis," NBER Chapters, in: Academic Science and Entrepreneurship: Dual Engines of Growth National Bureau of Economic Research, Inc.
  5. Jeffrey L. Furman & Scott Stern, 2006. "Climbing Atop the Shoulders of Giants: The Impact of Institutions on Cumulative Research," NBER Working Papers 12523, National Bureau of Economic Research, Inc.
  6. Murray, Fiona, 2002. "Innovation as co-evolution of scientific and technological networks: exploring tissue engineering," Research Policy, Elsevier, vol. 31(8-9), pages 1389-1403, December.
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Cited by:
  1. Joshua S. Gans & Fiona Murray, 2013. "Credit History: The Changing Nature of Scientific Credit," NBER Working Papers 19538, National Bureau of Economic Research, Inc.
  2. Thomas Hellman & Enrico Perotti, 2010. "The Circulation of Ideas in Firms and Markets," Working Papers 2010.47, Fondazione Eni Enrico Mattei.
  3. Anders Broström, 2012. "Firms’ rationales for interaction with research universities and the principles for public co-funding," The Journal of Technology Transfer, Springer, vol. 37(3), pages 313-329, June.
  4. repec:wip:wpaper:6 is not listed on IDEAS
  5. Joshua S. Gans & Fiona E. Murray & Scott Stern, 2013. "Contracting Over the Disclosure of Scientific Knowledge: Intellectual Property and Academic Publication," NBER Working Papers 19560, National Bureau of Economic Research, Inc.
  6. Czarnitzki, Dirk & Rammer, Christian & Toole, Andrew A., 2013. "University spinoffs and the 'performance premium'," ZEW Discussion Papers 13-004, ZEW - Zentrum für Europäische Wirtschaftsforschung / Center for European Economic Research.
  7. Alexy, Oliver & Reitzig, Markus, 2013. "Private–collective innovation, competition, and firms’ counterintuitive appropriation strategies," Research Policy, Elsevier, vol. 42(4), pages 895-913.
  8. Pierre Azoulay & Joshua S. Graff Zivin & Bhaven N. Sampat, 2011. "The Diffusion of Scientific Knowledge Across Time and Space: Evidence from Professional Transitions for the Superstars of Medicine," NBER Working Papers 16683, National Bureau of Economic Research, Inc.
  9. Simeth, Markus & Raffo, Julio D., 2013. "What makes companies pursue an Open Science strategy?," Research Policy, Elsevier, vol. 42(9), pages 1531-1543.
  10. Larsen, Maria Theresa, 2011. "The implications of academic enterprise for public science: An overview of the empirical evidence," Research Policy, Elsevier, vol. 40(1), pages 6-19, February.

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