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Is the Creation and Development of Biotech SMEs Localised? Conclusions Drawn from the French Case

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  • Stéphane Lemarié

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique - CNRS - Centre National de la Recherche Scientifique)

  • Vincent Mangematin

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique - CNRS - Centre National de la Recherche Scientifique, MTS - Management Technologique et Strategique - EESC-GEM Grenoble Ecole de Management)

  • A. Torre

    (SADAPT - Systèmes Agraires Développement : Activités, Produits, Territoires - INRA - Institut National de la Recherche Agronomique - INA P-G - Institut National Agronomique Paris-Grignon)

Abstract

The article examines the localisation effects within biotechnology, concentrating in particular on the French case. The paper has two strands of analysis. The first presents a detailed statistical survey of the French biotechnology sector. Among other things, the survey shows that a) localisation effects within France are strong, b) in terms of dependence on local cluster infrastructures (especially universities and related public research institutes), most firms progress from an entry stage in which they are very dependent on local cluster infrastructures, to a mature phase in which their networks become more national/international in focus and c) French firms can be grouped into four general types of firms, ranging from "type 1" growth oriented product firms, to "type 2" niche market players, " type 3" subsidiaries of larger firms, and "type 4" firms that have been acquired. Localisation effects differ across these firms, esp. across type 1 (international) and type 2 (very localised) firms. The second strand of analysis consists of a review of the localisation and related cluster literature, with implications drawn out for localisation and knowledge spillovers within biotech clusters. It examines the relative effects of scientific centres proximity and compares them to the public policy of start-up creation.

Suggested Citation

  • Stéphane Lemarié & Vincent Mangematin & A. Torre, 2001. "Is the Creation and Development of Biotech SMEs Localised? Conclusions Drawn from the French Case," Grenoble Ecole de Management (Post-Print) hal-00424329, HAL.
    • Handle: RePEc:hal:gemptp:hal-00424329
    DOI: 10.1023/A:1011197616151
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    Cited by:

    1. Dirk De Clercq & Deva Rangarajan, 2008. "The Role of Perceived Relational Support in Entrepreneur–Customer Dyads," Entrepreneurship Theory and Practice, , vol. 32(4), pages 659-683, July.
    2. Davenport, Sally, 2005. "Exploring the role of proximity in SME knowledge-acquisition," Research Policy, Elsevier, vol. 34(5), pages 683-701, June.
    3. Philip Cooke, 2004. "Life Sciences Clusters and Regional Science Policy," Urban Studies, Urban Studies Journal Limited, vol. 41(5-6), pages 1113-1131, May.
    4. Mangematin, Vincent & Lemarie, Stephane & Boissin, Jean-Pierre & Catherine, David & Corolleur, Frederic & Coronini, Roger & Trommetter, Michel, 2003. "Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France," Research Policy, Elsevier, vol. 32(4), pages 621-638, April.
    5. Zhang, Hengyuan & Yang, Yi & Xia, Chengcheng, 2023. "Flow and Ebb: Factors affecting SMEs to exit from the DRP market during pandemic," Journal of Business Research, Elsevier, vol. 154(C).
    6. Elicia Maine & Daniel Shapiro & Aidan Vining, 2010. "The role of clustering in the growth of new technology-based firms," Small Business Economics, Springer, vol. 34(2), pages 127-146, February.
    7. Fernhaber, Stephanie A. & Li, Dan, 2013. "International exposure through network relationships: Implications for new venture internationalization," Journal of Business Venturing, Elsevier, vol. 28(2), pages 316-334.
    8. Shiri M. Breznitz, 2013. "Cluster Sustainability," Economic Development Quarterly, , vol. 27(1), pages 29-39, February.
    9. Carolin Bock & Christian Hackober, 2020. "Unicorns—what drives multibillion-dollar valuations?," Business Research, Springer;German Academic Association for Business Research, vol. 13(3), pages 949-984, November.
    10. Kristina Jespersen & Damiana Rigamonti & Morten Berg Jensen & Rune Bysted, 2018. "Analysis of SMEs partner proximity preferences for process innovation," Small Business Economics, Springer, vol. 51(4), pages 879-904, December.
    11. Broström, Anders, 2010. "Working with distant researchers--Distance and content in university-industry interaction," Research Policy, Elsevier, vol. 39(10), pages 1311-1320, December.
    12. Robert J. Stimson, 2014. "Proximity and endogenous regional development," Chapters, in: André Torre & Frédéric Wallet (ed.), Regional Development and Proximity Relations, chapter 1, pages 47-93, Edward Elgar Publishing.
    13. Malgorzata RUNIEWICZ-WARDYN, 2017. "Dynamic Externalities, Universities and Social Capital Formation in the EU Biotechnology Industry," Management Dynamics in the Knowledge Economy, College of Management, National University of Political Studies and Public Administration, vol. 5(1), pages 13-31, March.
    14. Anne L.J. Ter Wal, 2011. "The Dynamics of the Inventor Network in German Biotechnology: Geographical Proximity versus Triadic Closure," Papers in Evolutionary Economic Geography (PEEG) 1102, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Jan 2011.
    15. Dominic Power & Mats Lundmark, 2004. "Working through Knowledge Pools: Labour Market Dynamics, the Transference of Knowledge and Ideas, and Industrial Clusters," Urban Studies, Urban Studies Journal Limited, vol. 41(5-6), pages 1025-1044, May.
    16. Marc-Hubert DEPRET & Abdelillah HAMDOUCH, 2011. "Multiscalar Clusters And Networks As The Foundations Of Innovation Dynamics In The Biopharmaceutical Industry," Region et Developpement, Region et Developpement, LEAD, Universite du Sud - Toulon Var, vol. 33, pages 227-268.
    17. Margarida Fontes, 2005. "Distant networking: The knowledge acquisition strategies of 'out-cluster' biotechnology firms," European Planning Studies, Taylor & Francis Journals, vol. 13(6), pages 899-920, September.
    18. Kolympiris, Christos & Kalaitzandonakes, Nicholas & Miller, Douglas, 2011. "Spatial collocation and venture capital in the US biotechnology industry," Research Policy, Elsevier, vol. 40(9), pages 1188-1199.

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