IDEAS home Printed from https://ideas.repec.org/p/hal/gemptp/hal-00422563.html
   My bibliography  Save this paper

Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France

Author

Listed:
  • Vincent Mangematin

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique - CNRS - Centre National de la Recherche Scientifique, MTS - Management Technologique et Strategique - EESC-GEM Grenoble Ecole de Management)

  • Stéphane Lemarié

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique - CNRS - Centre National de la Recherche Scientifique)

  • Jean-Pierre Boissin

    (CERAG - Centre d'études et de recherches appliquées à la gestion - UPMF - Université Pierre Mendès France - Grenoble 2 - CNRS - Centre National de la Recherche Scientifique)

  • David Catherine

    (MTS - Management Technologique et Strategique - EESC-GEM Grenoble Ecole de Management)

  • Frédéric Corolleur

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique - CNRS - Centre National de la Recherche Scientifique)

  • Roger Coronini

    (GAEL - Laboratoire d'Economie Appliquée = Grenoble Applied Economics Laboratory - UPMF - Université Pierre Mendès France - Grenoble 2 - INRA - Institut National de la Recherche Agronomique - CNRS - Centre National de la Recherche Scientifique)

  • Michel Trommetter

    (X-DEP-ECO - Département d'Économie de l'École Polytechnique - X - École polytechnique)

Abstract

Biotechnology is an emergent sector based on the creation of research-intensive Small and Medium Enterprises (SMEs). While some SMEs are growing, most of them remain small, even those set-up several years ago. What is the pattern of development of the biotech sector? What are the patterns of development of firms? Studies on the development of high-tech SMEs have focused on a business model, in which entrepreneurs rely on growth forecasts to persuade capital investors (business angels and venture capitalists) to invest in a radical innovation project. Firms aim for a world market to industrialise their innovation, and initial public offering (IPO) enables initial investors to make profits that offset risky initial investment. While this model is appealing, it is simply one of the possible models of biotechnology development. Some firms are not designed to experience exponential growth, and choose to target local markets. Moreover, not all firms have the ambition of being listed on the stock exchange. Based on an in-depth analysis of the business and development of 60 French biotech SMEs, this article identifies two business models. By defining the development trajectories of each of these models, it highlights the temporary nature of the emergent model.

Suggested Citation

  • Vincent Mangematin & Stéphane Lemarié & Jean-Pierre Boissin & David Catherine & Frédéric Corolleur & Roger Coronini & Michel Trommetter, 2003. "Development of SMEs and heterogeneity of trajectories: the case of biotechnology in France," Grenoble Ecole de Management (Post-Print) hal-00422563, HAL.
  • Handle: RePEc:hal:gemptp:hal-00422563
    DOI: 10.1016/S0048-7333(02)00045-8
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Other versions of this item:

    References listed on IDEAS

    as
    1. David J. TEECE, 2008. "Profiting from technological innovation: Implications for integration, collaboration, licensing and public policy," World Scientific Book Chapters, in: The Transfer And Licensing Of Know-How And Intellectual Property Understanding the Multinational Enterprise in the Modern World, chapter 5, pages 67-87, World Scientific Publishing Co. Pte. Ltd..
    2. Lemarie, Stephane & Mangematin, Vincent & Torre, Andre, 2001. "Is the Creation and Development of Biotech SMEs Localised? Conclusions Drawn from the French Case," Small Business Economics, Springer, vol. 17(1-2), pages 61-76, Aug.-Sept.
    3. Maryann Feldman, 1999. "The New Economics Of Innovation, Spillovers And Agglomeration: Areview Of Empirical Studies," Economics of Innovation and New Technology, Taylor & Francis Journals, vol. 8(1-2), pages 5-25.
    4. Lynne G. Zucker & Michael R. Darby & Jeff Armstrong, 1994. "Intellectual Capital and the Firm: The Technology of Geographically Localized Knowledge Spillovers," NBER Working Papers 4946, National Bureau of Economic Research, Inc.
    5. Audretsch, David B & Stephan, Paula E, 1996. "Company-Scientist Locational Links: The Case of Biotechnology," American Economic Review, American Economic Association, vol. 86(3), pages 641-652, June.
    6. Vincent Mangematin, 2000. "Competing business models in the french biotech industry," Grenoble Ecole de Management (Post-Print) hal-00422476, HAL.
    7. Vincent Mangematin, 2000. "Competing business models in the french biotech industry," Post-Print hal-00422476, HAL.
    8. Vincent Mangematin & André Torre, 2001. "Creation and development of biotech SMEs : the French case [Création et développement de PME dans le secteur des biotechnologies : le cas français]," Post-Print hal-02670171, HAL.
    9. David J. Teece & Richard Rumelt & Giovanni Dosi & Sidney Winter, 2000. "Understanding Corporate Coherence: Theory and Evidence," Chapters, in: Innovation, Organization and Economic Dynamics, chapter 9, pages 264-293, Edward Elgar Publishing.
    10. Mansfield, Edwin, 1995. "Academic Research Underlying Industrial Innovations:," The Review of Economics and Statistics, MIT Press, vol. 77(1), pages 55-65, February.
    11. Gary Hamel, 1991. "Competition for competence and interpartner learning within international strategic alliances," Strategic Management Journal, Wiley Blackwell, vol. 12(S1), pages 83-103, June.
    12. Arora, Ashish & Gambardella, Alfonso, 1990. "Complementarity and External Linkages: The Strategies of the Large Firms in Biotechnology," Journal of Industrial Economics, Wiley Blackwell, vol. 38(4), pages 361-379, June.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Vincent Mangematin, 2003. "PME de biotechnologie: Plusieurs Business models en concurrence," Post-Print hal-00422702, HAL.
    2. Vincent Mangematin, 2003. "PME de biotechnologie: Plusieurs Business models en concurrence," Grenoble Ecole de Management (Post-Print) hal-00422702, HAL.
    3. Margarida Fontes, 2005. "Distant networking: The knowledge acquisition strategies of 'out-cluster' biotechnology firms," European Planning Studies, Taylor & Francis Journals, vol. 13(6), pages 899-920, September.
    4. René Belderbos & Marcelina Grabowska & Stijn Kelchtermans & Bart Leten & Jojo Jacob & Massimo Riccaboni, 2021. "Whither geographic proximity? Bypassing local R&D units in foreign university collaboration," Journal of International Business Studies, Palgrave Macmillan;Academy of International Business, vol. 52(7), pages 1302-1330, September.
    5. Tom Broekel & Matthias Brachert, 2015. "The structure and evolution of inter-sectoral technological complementarity in R&D in Germany from 1990 to 2011," Journal of Evolutionary Economics, Springer, vol. 25(4), pages 755-785, September.
    6. Lee Branstetter & Kwon Hyeog Ug, 2004. "The Restructuring Of Japanese Research And Development: The Increasing Impact Of Science On Japanese R&D," Discussion papers 04021, Research Institute of Economy, Trade and Industry (RIETI).
    7. Rajneesh Narula & Andrea Martínez-Noya, 2014. "International R&D Alliances by Firms: Origins and Development," John H Dunning Centre for International Business Discussion Papers jhd-dp2014-06, Henley Business School, University of Reading.
    8. Breschi, Stefano & Lissoni, Francesco, 2001. "Knowledge Spillovers and Local Innovation Systems: A Critical Survey," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 10(4), pages 975-1005, December.
    9. Rocha, Frederico, 1997. "Inter-Firm Technological Cooperation Effects of Absorptive Capacity, Firm-Size and Specialization," UNU-INTECH Discussion Paper Series 1997-07, United Nations University - INTECH.
    10. Autant-Bernard, Corinne, 2001. "Science and knowledge flows: evidence from the French case," Research Policy, Elsevier, vol. 30(7), pages 1069-1078, August.
    11. Richards, Malika & De Carolis, Donna Marie, 2003. "Joint venture research and development activity: an analysis of the international biotechnology industry," Journal of International Management, Elsevier, vol. 9(1), pages 33-49.
    12. Mahka Moeen & Rajshree Agarwal, 2017. "Incubation of an industry: Heterogeneous knowledge bases and modes of value capture," Strategic Management Journal, Wiley Blackwell, vol. 38(3), pages 566-587, March.
    13. Lee Branstetter & Yoshiaki Ogura, 2005. "Is Academic Science Driving a Surge in Industrial Innovation? Evidence from Patent Citations," NBER Working Papers 11561, National Bureau of Economic Research, Inc.
    14. Kolympiris, Christos & Kalaitzandonakes, Nicholas & Miller, Douglas, 2011. "Spatial collocation and venture capital in the US biotechnology industry," Research Policy, Elsevier, vol. 40(9), pages 1188-1199.
    15. Nobuya Fukugawa, 2013. "University spillovers into small technology-based firms: channel, mechanism, and geography," The Journal of Technology Transfer, Springer, vol. 38(4), pages 415-431, August.
    16. Gambardella, Alfonso & Torrisi, Salvatore, 1998. "Does technological convergence imply convergence in markets? Evidence from the electronics industry," Research Policy, Elsevier, vol. 27(5), pages 445-463, September.
    17. Braunerhjelm, Pontus, 2006. "Regional Specialization and Universities: The New Verus the Old," Working Paper Series in Economics and Institutions of Innovation 55, Royal Institute of Technology, CESIS - Centre of Excellence for Science and Innovation Studies.
    18. Cristiano Antonelli, 2003. "Knowledge Complementarity and Fungeability: Implications for Regional Strategy," Regional Studies, Taylor & Francis Journals, vol. 37(6-7), pages 595-606.
    19. Mirja Meyborg & Axel Schaffer, 2014. "Regional and global collaborations for knowledge in German academia," Review of Regional Research: Jahrbuch für Regionalwissenschaft, Springer;Gesellschaft für Regionalforschung (GfR), vol. 34(2), pages 157-176, October.
    20. Francisco Polidoro & Curba Morris Lampert & Minyoung Kim, 2022. "External knowledge sourcing, knowledge spillovers, and internal collaboration: The effects of intrafirm linkages on firm‐university co‐authorship linkages," Strategic Management Journal, Wiley Blackwell, vol. 43(13), pages 2742-2776, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:gemptp:hal-00422563. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: CCSD (email available below). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.