Resource costing for multinational neurologic clinical trials: methods and results

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Resource costing for multinational neurologic clinical trials: methods and results

Author Info

Kevin Schulman (Clinical Economics Research Unit, Georgetown University Medical Center, Washington, DC, USA)
Jennifer Burke (Clinical Economics Research Unit, Georgetown University Medical Center, Washington, DC, USA)
Michael Drummond (Centre for Health Economics, University of York, York, UK)
Linda Davies (Centre for Health Economics, University of York, York, UK)
Per Carlsson (Center for Medical Technology Assessment, Linkoping University, Sweden)
Jans Gruger (SmithKline Beecham Pharma GmbH, Munich, Germany)
Anthony Harris (Centre for Health Program Evaluation, Monash University, West Heidelberg, Australia)
Carlo Lucioni (Institute for Health Economics, Milan, Italy)
Ramon Gisbert (SOIKOS, SL, Barcelona, Spain)
Ted Llana (Covance Health Economics and Outcomes Services, West Sussex, UK)
Eric Tom (Clinical Economics Research Unit, Georgetown University Medical Center, Washington, DC, USA)
Bernard Bloom (University of Pennsylvania, Division of General Internal Medicine, Philadelphia, PA, USA)
Richard Willke (Pharmacia & Upjohn, Inc., Kalamazoo, MI, USA)
Henry Glick (University of Pennsylvania, Division of General Internal Medicine, Philadelphia, PA, USA)

Additional information is available for the following registered author(s):

Anthony Howard Harris

Abstract

We present the results of a multinational resource costing study for a prospective economic evaluation of a new medical technology for treatment of subarachnoid hemorrhage within a clinical trial. The study describes a framework for the collection and analysis of international resource cost data that can contribute to a consistent and accurate intercountry estimation of cost. Of the 15 countries that participated in the clinical trial, we collected cost information in the following seven: Australia, France, Germany, the UK, Italy, Spain, and Sweden. The collection of cost data in these countries was structured through the use of worksheets to provide accurate and efficient cost reporting. We converted total average costs to average variable costs and then aggregated the data to develop study unit costs. When unit costs were unavailable, we developed an index table, based on a market-basket approach, to estimate unit costs. To estimate the cost of a given procedure, the market-basket estimation process required that cost information be available for at least one country. When cost information was unavailable in all countries for a given procedure, we estimated costs using a method based on physician-work and practice-expense resource-based relative value units. Finally, we converted study unit costs to a common currency using purchasing power parity measures. Through this costing exercise we developed a set of unit costs for patient services and per diem hospital services. We conclude by discussing the implications of our costing exercise and suggest guidelines to facilitate more effective multinational costing exercises. © 1998 John Wiley & Sons, Ltd.

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Article provided by John Wiley & Sons, Ltd. in its journal Health Economics.

Volume (Year): 7 (1998)
Issue (Month): 7 ()
Pages: 629-638
Download reference. The following formats are available: HTML (with abstract), plain text (with abstract), BibTeX, RIS (EndNote, RefMan, ProCite), ReDIF
Handle: RePEc:wly:hlthec:v:7:y:1998:i:7:p:629-638

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Web page: http://www3.interscience.wiley.com/cgi-bin/jhome/5749

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Christopher J.L. Murray & David B. Evans & Arnab Acharya & Rob M.P.M. Baltussen, 2000. "Development of WHO guidelines on generalized cost-effectiveness analysis," Health Economics, John Wiley & Sons, Ltd., vol. 9(3), pages 235-251.
Sarah Wordsworth & Anne Ludbrook, 2005. "Comparing costing results in across country economic evaluations: the use of technology specific purchasing power parities," Health Economics, John Wiley & Sons, Ltd., vol. 14(1), pages 93-99. [Downloadable!]
Jonas Schreyögg & Oliver Tiemann & Tom Stargardt & Reinhard Busse, 2008. "Cross-country comparisons of costs: the use of episode-specific transitive purchasing power parities with standardised cost categories," Health Economics, John Wiley & Sons, Ltd., vol. 17(S1), pages S95-S103. [Downloadable!]
Andrew R. Willan & Eleanor M. Pinto & Bernie J. O'Brien & Padma Kaul & Ron Goeree & Larry Lynd & Paul W. Armstrong, 2005. "Country specific cost comparisons from multinational clinical trials using empirical Bayesian shrinkage estimation: the Canadian ASSENT-3 economic analysis," Health Economics, John Wiley & Sons, Ltd., vol. 14(4), pages 327-338. [Downloadable!]

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