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Whole exome sequencing in molecular diagnostics of cancer decreases over time: evidence from a cost analysis in the French setting

Author

Listed:
  • Arnaud Bayle

    (Gustave Roussy Cancer Centre
    INSERM U1018
    Université Paris-Sud)

  • N. Droin

    (Gustave Roussy Cancer Centre
    AMMICa, Gustave Roussy)

  • B. Besse

    (Gustave Roussy Cancer Centre)

  • Z. Zou

    (Gustave Roussy Cancer Centre
    INSERM U1018)

  • Y. Boursin

    (Gustave Roussy Cancer Centre)

  • S. Rissel

    (Gustave Roussy Cancer Centre)

  • E. Solary

    (Gustave Roussy Cancer Centre
    Université Paris-Sud)

  • L. Lacroix

    (Gustave Roussy Cancer Centre
    AMMICa, Gustave Roussy
    Université Paris-Sud)

  • E. Rouleau

    (Gustave Roussy Cancer Centre)

  • I. Borget

    (Gustave Roussy Cancer Centre
    INSERM U1018
    Université Paris-Sud)

  • J. Bonastre

    (Gustave Roussy Cancer Centre
    INSERM U1018)

Abstract

Objectives Although high-throughput sequencing is revolutionising medicine, data on the actual cost of whole exome sequencing (WES) applications are needed. We aimed at assessing the cost of WES at a French cancer institute in 2015 and 2018. Methods Actual costs of WES application in oncology research were determined using both micro-costing and gross-costing for the years 2015 and 2018, before and after the acquisition of a new sequencer. The entire workflow process of a WES test was tracked, and the number and unit price of each resource were identified at the most detailed level, from library preparation to bioinformatics analyses. In addition, we conducted an ad hoc analysis of the bioinformatics storage costs of data issued from WES analyses. Results The cost of WES has decreased substantially, from €1921 per sample (i.e. cost of €3842 per patient) in 2015 to €804 per sample (i.e. cost of €1,608 per patient) in 2018, representing a decrease of 58%. In the meantime, the cost of bioinformatics storage has increased from €19,836 to €200,711. Conclusion This study suggests that WES cost has decreased significantly in recent years. WES has become affordable, even though clinical utility and efficiency still need to be confirmed.

Suggested Citation

  • Arnaud Bayle & N. Droin & B. Besse & Z. Zou & Y. Boursin & S. Rissel & E. Solary & L. Lacroix & E. Rouleau & I. Borget & J. Bonastre, 2021. "Whole exome sequencing in molecular diagnostics of cancer decreases over time: evidence from a cost analysis in the French setting," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 22(6), pages 855-864, August.
    • Handle: RePEc:spr:eujhec:v:22:y:2021:i:6:d:10.1007_s10198-021-01293-1
    DOI: 10.1007/s10198-021-01293-1
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    References listed on IDEAS

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    1. Drummond, Michael F. & Sculpher, Mark J. & Claxton, Karl & Stoddart, Greg L. & Torrance, George W., 2015. "Methods for the Economic Evaluation of Health Care Programmes," OUP Catalogue, Oxford University Press, edition 4, number 9780199665884.
    2. Marika Plöthner & Martin Frank & J.-Matthias Graf Schulenburg, 2017. "Cost analysis of whole genome sequencing in German clinical practice," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 18(5), pages 623-633, June.
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