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Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis

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  • Jennifer B Griffin
  • Kathleen Ridgeway
  • Elizabeth Montgomery
  • Kristine Torjesen
  • Rachel Clark
  • Jill Peterson
  • Rachel Baggaley
  • Ariane van der Straten

Abstract

The vaginal ring (VR) is a female-initiated drug-delivery platform used for different indications, including HIV pre-exposure prophylaxis (PrEP). We conducted a systematic review of VR acceptability, values and preferences among women in low- and middle-income countries (LMIC) to inform further investment and/or guidance on VR use for HIV prevention. Following PRISMA guidelines, we used structured methods to search, screen, and extract data from randomized controlled trials (RCTs) and observational studies reporting quantitative outcomes of acceptability of the VR for any indication published 1/1970-2/2019 (PROSPERO: CRD42019122220). Of 1,110 records identified, 68 met inclusion criteria. Studies included women 15–50+ years from 25 LMIC for indications including HIV prevention, contraception, abnormal bleeding, and menopause. Overall VR acceptability was high (71–98% across RCTs; 62–100% across observational studies), with 80–100% continuation rates in RCTs and favorable ease of insertion (greater than 85%) and removal 89–99%). Users reported concerns about the VR getting lost in the body (8–43%), although actual expulsions and adverse events were generally infrequent. Most women disclosed use to partners, with some worrying about partner anger/violence. The VR was not felt during intercourse by 70–92% of users and 48–97% of partners. Acceptability improved over time both within studies (as women gained VR experience and worries diminished), and over chronological time (as the device was popularized). Women expressed preferences for accessible, long-acting, partner-approved methods that prevent both HIV and pregnancy, can be used without partner knowledge, and have no impact on sex and few side effects. This review was limited by a lack of standardization of acceptability measures and study heterogeneity. This systematic review suggests that most LMIC women users have a positive view of the VR that increases with familiarity of use; and, that many would consider the VR an acceptable future delivery device for HIV prevention or other indications.

Suggested Citation

  • Jennifer B Griffin & Kathleen Ridgeway & Elizabeth Montgomery & Kristine Torjesen & Rachel Clark & Jill Peterson & Rachel Baggaley & Ariane van der Straten, 2019. "Vaginal ring acceptability and related preferences among women in low- and middle-income countries: A systematic review and narrative synthesis," PLOS ONE, Public Library of Science, vol. 14(11), pages 1-22, November.
  • Handle: RePEc:plo:pone00:0224898
    DOI: 10.1371/journal.pone.0224898
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. S. Wilson Beckham & Norah L. Crossnohere & Margaret Gross & John F. P. Bridges, 2021. "Eliciting Preferences for HIV Prevention Technologies: A Systematic Review," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 14(2), pages 151-174, March.

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