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Bevacizumab Combined with Chemotherapy Improves Survival for Patients with Metastatic Colorectal Cancer: Evidence from Meta Analysis

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  • Irena Ilic
  • Slobodan Jankovic
  • Milena Ilic

Abstract

Background: Colorectal cancer is one of the leading causes of cancer deaths in both sexes in the world. Improvement of existing therapy modalities and implementing new ones in order to improve survival of patients with colorectal cancer represents a great challenge for medicine. The aim of this paper was to assess the impact that adding bevacizumab to chemotherapy has on survival in patients with metastatic colorectal cancer, compared to the use of chemotherapy alone. Methods: Hazard ratios (HRs) with their 95% confidence intervals (CI) were determined from the studies and pooled. Two-sided p values were reported and considered to indicate statistical significance if less than 0.05. Results: A total of 12 studies that meet the inclusion criteria were identified in the literature search, 3 phase II studies and 9 phase III studies. Based on the random effects meta-analysis, a statistically significant improvement was identified for both overall survival (HR = 0.84; 95% CI: 0.74–0.94; p = 0.003) and progression free survival (HR = 0.64; 95% CI: 0.55–0.73; p

Suggested Citation

  • Irena Ilic & Slobodan Jankovic & Milena Ilic, 2016. "Bevacizumab Combined with Chemotherapy Improves Survival for Patients with Metastatic Colorectal Cancer: Evidence from Meta Analysis," PLOS ONE, Public Library of Science, vol. 11(8), pages 1-15, August.
    • Handle: RePEc:plo:pone00:0161912
    DOI: 10.1371/journal.pone.0161912
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    References listed on IDEAS

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    1. Yuan Su & Wei-Bing Yang & Shi Li & Zhi-Jian Ye & Huan-Zhong Shi & Qiong Zhou, 2012. "Effect of Angiogenesis Inhibitor Bevacizumab on Survival in Patients with Cancer: A Meta-Analysis of the Published Literature," PLOS ONE, Public Library of Science, vol. 7(4), pages 1-1, April.
    2. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Dániel András Drexler & Johanna Sápi & Levente Kovács, 2017. "Modeling of Tumor Growth Incorporating the Effects of Necrosis and the Effect of Bevacizumab," Complexity, Hindawi, vol. 2017, pages 1-10, November.

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