IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0147303.html
   My bibliography  Save this article

C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus

Author

Listed:
  • Remi Sonoda
  • Kentaro Tanaka
  • Takako Kikuchi
  • Yukiko Onishi
  • Toshiko Takao
  • Tazu Tahara
  • Yoko Yoshida
  • Naoki Suzawa
  • Shoji Kawazu
  • Yasuhiko Iwamoto
  • Akifumi Kushiyama

Abstract

In this study, we investigate how measures of insulin secretion and other clinical information affect long-term glycemic control in patients with type 2 diabetes mellitus. Between October 2012 and June 2014, we monitored 202 diabetes patients who were admitted to the hospital of Asahi Life Foundation for glycemic control, as well as for training and education in diabetes management. We measured glycated hemoglobin (HbA1c) six months after discharge to assess disease management. In univariate analysis, fasting plasma C-peptide immunoreactivity (F-CPR) and pooled urine CPR (U-CPR) were significantly associated with HbA1c, in contrast to ΔCPR and C-peptide index (CPI). This association was strongly independent of most other patient variables. In exploratory factor analysis, five underlying factors, namely insulin resistance, aging, sex differences, insulin secretion, and glycemic control, represented patient characteristics. In particular, insulin secretion and resistance strongly influenced F-CPR, while insulin secretion affected U-CPR. In conclusion, the data indicate that among patients with type 2 diabetes mellitus, F-CPR and U-CPR may predict improved glycemic control six months after hospitalization.

Suggested Citation

  • Remi Sonoda & Kentaro Tanaka & Takako Kikuchi & Yukiko Onishi & Toshiko Takao & Tazu Tahara & Yoko Yoshida & Naoki Suzawa & Shoji Kawazu & Yasuhiko Iwamoto & Akifumi Kushiyama, 2016. "C-Peptide Level in Fasting Plasma and Pooled Urine Predicts HbA1c after Hospitalization in Patients with Type 2 Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 11(2), pages 1-13, February.
    • Handle: RePEc:plo:pone00:0147303
    DOI: 10.1371/journal.pone.0147303
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147303
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0147303&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0147303?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Padmaja Ayyagari & Daniel Grossman & Frank Sloan, 2011. "Education and health: evidence on adults with diabetes," International Journal of Health Economics and Management, Springer, vol. 11(1), pages 35-54, March.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lydia Lawless & Andreas Drichoutis & Rodolfo Nayga, 2013. "Time preferences and health behaviour: a review," Agricultural and Food Economics, Springer;Italian Society of Agricultural Economics (SIDEA), vol. 1(1), pages 1-19, December.
    2. Kim, Young-Joo & Daly, Vincent, 2019. "The Education Gradient in Health: The Case of Obesity in the UK and US," Economics Discussion Papers 2019-4, School of Economics, Kingston University London.
    3. Herberholz, Chantal, 2020. "Risk attitude, time preference and health behaviours in the Bangkok Metropolitan Area," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 87(C).
    4. Shai, Ori, 2022. "Out of time? The effect of an infrequent traumatic event on individuals’ time and risk preferences, beliefs, and insurance purchasing," Journal of Health Economics, Elsevier, vol. 86(C).

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0147303. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.