IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0123523.html
   My bibliography  Save this article

Breast Cancer Biology and Ethnic Disparities in Breast Cancer Mortality in New Zealand: A Cohort Study

Author

Listed:
  • Sanjeewa Seneviratne
  • Ross Lawrenson
  • Nina Scott
  • Boa Kim
  • Rachel Shirley
  • Ian Campbell

Abstract

Introduction: Indigenous Māori women have a 60% higher breast cancer mortality rate compared with European women in New Zealand. We investigated differences in cancer biological characteristics and their impact on breast cancer mortality disparity between Māori and NZ European women. Materials and Methods: Data on 2849 women with primary invasive breast cancers diagnosed between 1999 and 2012 were extracted from the Waikato Breast Cancer Register. Differences in distribution of cancer biological characteristics between Māori and NZ European women were explored adjusting for age and socioeconomic deprivation in logistic regression models. Impacts of socioeconomic deprivation, stage and cancer biological characteristics on breast cancer mortality disparity between Māori and NZ European women were explored in Cox regression models. Results: Compared with NZ European women (n=2304), Māori women (n=429) had significantly higher rates of advanced and higher grade cancers. Māori women also had non-significantly higher rates of ER/PR negative and HER-2 positive breast cancers. Higher odds of advanced stage and higher grade remained significant for Māori after adjusting for age and deprivation. Māori women had almost a 100% higher age and deprivation adjusted breast cancer mortality hazard compared with NZ European women (HR=1.98, 1.55-2.54). Advanced stage and lower proportion of screen detected cancer in Māori explained a greater portion of the excess breast cancer mortality (HR reduction from 1.98 to 1.38), while the additional contribution through biological differences were minimal (HR reduction from 1.38 to 1.35). Conclusions: More advanced cancer stage at diagnosis has the greatest impact while differences in biological characteristics appear to be a minor contributor for inequities in breast cancer mortality between Māori and NZ European women. Strategies aimed at reducing breast cancer mortality in Māori should focus on earlier diagnosis, which will likely have a greater impact on reducing breast cancer mortality inequity between Māori and NZ European women.

Suggested Citation

  • Sanjeewa Seneviratne & Ross Lawrenson & Nina Scott & Boa Kim & Rachel Shirley & Ian Campbell, 2015. "Breast Cancer Biology and Ethnic Disparities in Breast Cancer Mortality in New Zealand: A Cohort Study," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-13, April.
    • Handle: RePEc:plo:pone00:0123523
    DOI: 10.1371/journal.pone.0123523
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123523
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0123523&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0123523?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Jeffreys, M. & Stevanovic, V. & Tobias, M. & Lewis, C. & Ellison-Loschmann, L. & Pearce, N. & Blakely, T., 2005. "Ethnic inequalities in cancer survival in New Zealand: Linkage study," American Journal of Public Health, American Public Health Association, vol. 95(5), pages 834-837.
    2. Haynes, Robin & Pearce, Jamie & Barnett, Ross, 2008. "Cancer survival in New Zealand: Ethnic, social and geographical inequalities," Social Science & Medicine, Elsevier, vol. 67(6), pages 928-937, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Sukanya Chongthawonsatid, 2017. "Inequity of healthcare utilization on mammography examination and Pap smear screening in Thailand: Analysis of a population-based household survey," PLOS ONE, Public Library of Science, vol. 12(3), pages 1-12, March.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Haynes, Robin & Pearce, Jamie & Barnett, Ross, 2008. "Cancer survival in New Zealand: Ethnic, social and geographical inequalities," Social Science & Medicine, Elsevier, vol. 67(6), pages 928-937, September.
    2. Pearson, Amber L. & Pearce, Jamie & Kingham, Simon, 2013. "Deprived yet healthy: Neighbourhood-level resilience in New Zealand," Social Science & Medicine, Elsevier, vol. 91(C), pages 238-245.
    3. Rekhter, Natalia & Ermasova, Natalia, 2021. "Culture of prevention and early disease detection of cancer in Russia," Social Science & Medicine, Elsevier, vol. 277(C).
    4. Margaret A. Brunton, 2009. "The Role of Effective Communication to Enhance Participation in Screening Mammography: A New Zealand Case," IJERPH, MDPI, vol. 6(2), pages 1-18, February.
    5. Laura Kuznetsov & Werner Maier & Matthias Hunger & Martin Meyer & Andreas Mielck, 2012. "Regional deprivation in Bavaria, Germany: linking a new deprivation score with registry data for lung and colorectal cancer," International Journal of Public Health, Springer;Swiss School of Public Health (SSPH+), vol. 57(5), pages 827-835, October.
    6. Lusine Yaghjyan & Christopher R. Cogle & Guangran Deng & Jue Yang & Pauline Jackson & Nancy Hardt & Jaclyn Hall & Liang Mao, 2019. "Continuous Rural-Urban Coding for Cancer Disparity Studies: Is It Appropriate for Statistical Analysis?," IJERPH, MDPI, vol. 16(6), pages 1-14, March.
    7. Peipins, Lucy A. & Graham, Shannon & Young, Randall & Lewis, Brian & Flanagan, Barry, 2013. "Racial disparities in travel time to radiotherapy facilities in the Atlanta metropolitan area," Social Science & Medicine, Elsevier, vol. 89(C), pages 32-38.
    8. Kashif Shafique & David S Morrison, 2013. "Socio-Economic Inequalities in Survival of Patients with Prostate Cancer: Role of Age and Gleason Grade at Diagnosis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    9. Klein, Jens & von dem Knesebeck, Olaf, 2015. "Socioeconomic inequalities in prostate cancer survival: A review of the evidence and explanatory factors," Social Science & Medicine, Elsevier, vol. 142(C), pages 9-18.
    10. Jofre-Bonet, Mireia & Serra-Sastre, Victoria & Vandoros, Sotiris, 2018. "The impact of the Great Recession on health-related risk factors, behaviour and outcomes in England," Social Science & Medicine, Elsevier, vol. 197(C), pages 213-225.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0123523. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.