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Association between the ENPP1 K121Q Polymorphism and Risk of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis

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Listed:
  • Denise Alves Sortica
  • Marjorie Piucco Buffon
  • Bianca Marmontel Souza
  • Bruna Bellicanta Nicoletto
  • Andressa Santer
  • Tais Silveira Assmann
  • Daisy Crispim
  • Luis Henrique Canani

Abstract

The potential association between the K121Q (A/C, rs1044498) polymorphism in the ectonucleotide pyrophosphatase/phosphodiesterase (ENPP1) gene and risk of diabetic kidney disease (DKD) has been investigated. Nevertheless, the effect of this variant on DKD risk is still under debate, and conflicting results have been reported. To this date, no meta-analysis has evaluated the association of the K121Q polymorphism with DKD. This paper describes the first meta-analysis conducted to evaluate whether the ENPP1K121Q polymorphism is associated with DKD. A literature search was conducted to identify all case-control or cross-sectional studies that evaluated associations between the ENPP1K121Q polymorphism and DKD. Pooled odds ratios (OR) and 95% confidence intervals (95% CI) were calculated for allele contrast, additive, dominant and recessive inheritance models. Seven studies were eligible for inclusion in the meta-analysis, providing data on 3571 type 1 or type 2 diabetic patients (1606 cases with DKD and 1965 diabetic controls without this complication). No significant heterogeneity was observed among the studies included in the meta-analysis when assuming different inheritance models (I² 0.10 for the entire sample and after stratification by ethnicity). Meta-analysis results revealed significant associations between the K121Q polymorphism and risk of DKD in Asians and Europeans when assuming the different inheritance models analyzed. The most powerful association was observed for the additive model (OR = 1.74, 95% CI 1.27-2.38 for the total sample). In conclusion, the present meta-analysis detected a significant association between the ENPP1K121Q polymorphism and increased susceptibility of DKD in European and Asian populations.

Suggested Citation

  • Denise Alves Sortica & Marjorie Piucco Buffon & Bianca Marmontel Souza & Bruna Bellicanta Nicoletto & Andressa Santer & Tais Silveira Assmann & Daisy Crispim & Luis Henrique Canani, 2015. "Association between the ENPP1 K121Q Polymorphism and Risk of Diabetic Kidney Disease: A Systematic Review and Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(3), pages 1-13, March.
    • Handle: RePEc:plo:pone00:0118416
    DOI: 10.1371/journal.pone.0118416
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Letícia A Brondani & Tais S Assmann & Bianca M de Souza & Ana P Bouças & Luis H Canani & Daisy Crispim, 2014. "Meta-Analysis Reveals the Association of Common Variants in the Uncoupling Protein (UCP) 1–3 Genes with Body Mass Index Variability," PLOS ONE, Public Library of Science, vol. 9(5), pages 1-10, May.
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    1. Denise A Sortica & Daisy Crispim & Andrea C Bauer & Pamela S Nique & Bruna B Nicoletto & Ricieli P Crestani & Jennifer T Staehler & Roberto C Manfro & Luis H Canani, 2019. "K121Q polymorphism in the Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 gene is associated with acute kidney rejection," PLOS ONE, Public Library of Science, vol. 14(7), pages 1-12, July.

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