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Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis

Author

Listed:
  • Changmei Gu
  • Jiachun Lu
  • Tianpen Cui
  • Cheng Lu
  • Hao Shi
  • Wenmao Xu
  • Xueli Yuan
  • Xiaobo Yang
  • Yangxin Huang
  • Meixia Lu

Abstract

Background: O6-methylguanine-DNA methyltransferase (MGMT) is one of most important DNA repair enzyme against common carcinogens such as alkylate and tobacco. Aberrant promoter methylation of the gene is frequently observed in non-small cell lung cancer (NSCLC). However, the importance of epigenetic inactivation of the gene in NSCLC published in the literature showed inconsistence. We quantified the association between MGMT promoter methylation and NSCLC using a meta-analysis method. Methods: We systematically reviewed studies of MGMT promoter methylation and NSCLC in PubMed, EMBASE, Ovid, ISI Web of Science, Elsevier and CNKI databases and quantified the association between MGMT promoter methylation and NSCLC using meta-analysis method. Odds ratio (OR) and corresponding 95% confidence interval (CI) were calculated to evaluate the strength of association. Potential sources of heterogeneity were assessed by subgroup analysis and meta-regression. Results: A total of 18 studies from 2001 to 2011, with 1, 160 tumor tissues and 970 controls, were involved in the meta-analysis. The frequencies of MGMT promote methylation ranged from 1.5% to 70.0% (median, 26.1%) in NSCLC tissue and 0.0% to 55.0% (median, 2.4%) in non-cancerous control, respectively. The summary of OR was 4.43 (95% CI: 2.85, 6.89) in the random-effects model. With stratification by potential source of heterogeneity, the OR was 20.45 (95% CI: 5.83, 71.73) in heterogeneous control subgroup, while it was 4.16 (95% CI: 3.02, 5.72) in the autologous control subgroup. The OR was 5.31 (95% CI: 3.00, 9.41) in MSP subgroup and 3.06 (95% CI: 1.75, 5.33) in Q-MSP subgroup. Conclusion: This meta-analysis identified a strong association between methylation of MGMT gene and NSCLC. Prospective studies should be required to confirm the results in the future.

Suggested Citation

  • Changmei Gu & Jiachun Lu & Tianpen Cui & Cheng Lu & Hao Shi & Wenmao Xu & Xueli Yuan & Xiaobo Yang & Yangxin Huang & Meixia Lu, 2013. "Association between MGMT Promoter Methylation and Non-Small Cell Lung Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(9), pages 1-1, September.
    • Handle: RePEc:plo:pone00:0072633
    DOI: 10.1371/journal.pone.0072633
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
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    1. Chihao Shao & Wenzhu Dai & Haili Li & Wenru Tang & Shuting Jia & Xiaoming Wu & Ying Luo, 2017. "The relationship between RASSF1A gene promoter methylation and the susceptibility and prognosis of melanoma: A meta-analysis and bioinformatics," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-12, February.
    2. Di Liu & Hongli Peng & Qi Sun & Zhongyao Zhao & Xinwei Yu & Siqi Ge & Hao Wang & Honghong Fang & Qing Gao & Jiaonan Liu & Lijuan Wu & Manshu Song & Youxin Wang, 2017. "The Indirect Efficacy Comparison of DNA Methylation in Sputum for Early Screening and Auxiliary Detection of Lung Cancer: A Meta-Analysis," IJERPH, MDPI, vol. 14(7), pages 1-14, June.

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