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Why is congenital Zika syndrome asymmetrically distributed among human populations?

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  • Jimena Barbeito-Andrés
  • Lavínia Schuler-Faccini
  • Patricia Pestana Garcez

Abstract

Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus’ genome as well as examining the diverse genetic and environmental cofactors of the human hosts.

Suggested Citation

  • Jimena Barbeito-Andrés & Lavínia Schuler-Faccini & Patricia Pestana Garcez, 2018. "Why is congenital Zika syndrome asymmetrically distributed among human populations?," PLOS Biology, Public Library of Science, vol. 16(8), pages 1-11, August.
  • Handle: RePEc:plo:pbio00:2006592
    DOI: 10.1371/journal.pbio.2006592
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    Cited by:

    1. Rachel Sippy & Daniel F Farrell & Daniel A Lichtenstein & Ryan Nightingale & Megan A Harris & Joseph Toth & Paris Hantztidiamantis & Nicholas Usher & Cinthya Cueva Aponte & Julio Barzallo Aguilar & An, 2020. "Severity Index for Suspected Arbovirus (SISA): Machine learning for accurate prediction of hospitalization in subjects suspected of arboviral infection," PLOS Neglected Tropical Diseases, Public Library of Science, vol. 14(2), pages 1-20, February.

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