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Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’

Author

Listed:
  • Enrico Lavezzo

    (University of Padova)

  • Elisa Franchin

    (University of Padova)

  • Constanze Ciavarella

    (Imperial College London)

  • Gina Cuomo-Dannenburg

    (Imperial College London)

  • Luisa Barzon

    (University of Padova)

  • Claudia Del Vecchio

    (University of Padova)

  • Lucia Rossi

    (Azienda Ospedale Padova)

  • Riccardo Manganelli

    (University of Padova)

  • Arianna Loregian

    (University of Padova)

  • Nicolò Navarin

    (University of Padova
    University of Padova)

  • Davide Abate

    (University of Padova)

  • Manuela Sciro

    (Azienda Ospedale Padova)

  • Stefano Merigliano

    (University of Padova)

  • Ettore De Canale

    (Azienda Ospedale Padova)

  • Maria Cristina Vanuzzo

    (Azienda Ospedale Padova)

  • Valeria Besutti

    (Azienda Ospedale Padova)

  • Francesca Saluzzo

    (University of Padova)

  • Francesco Onelia

    (University of Padova)

  • Monia Pacenti

    (Azienda Ospedale Padova)

  • Saverio G. Parisi

    (University of Padova)

  • Giovanni Carretta

    (Azienda Ospedale Padova)

  • Daniele Donato

    (Azienda Ospedale Padova)

  • Luciano Flor

    (Azienda Ospedale Padova)

  • Silvia Cocchio

    (University of Padova)

  • Giulia Masi

    (University of Padova)

  • Alessandro Sperduti

    (University of Padova
    University of Padova)

  • Lorenzo Cattarino

    (Imperial College London)

  • Renato Salvador

    (University of Padova)

  • Michele Nicoletti

    (University of Padova)

  • Federico Caldart

    (University of Padova)

  • Gioele Castelli

    (University of Padova)

  • Eleonora Nieddu

    (University of Padova)

  • Beatrice Labella

    (University of Padova)

  • Ludovico Fava

    (University of Padova)

  • Matteo Drigo

    (University of Padova)

  • Katy A. M. Gaythorpe

    (Imperial College London)

  • Alessandra R. Brazzale

    (University of Padova)

  • Stefano Toppo

    (University of Padova
    University of Padova)

  • Marta Trevisan

    (University of Padova)

  • Vincenzo Baldo

    (University of Padova)

  • Christl A. Donnelly

    (Imperial College London
    University of Oxford)

  • Neil M. Ferguson

    (Imperial College London)

  • Ilaria Dorigatti

    (Imperial College London)

  • Andrea Crisanti

    (University of Padova
    Imperial College London)

Abstract

On 21 February 2020, a resident of the municipality of Vo’, a small town near Padua (Italy), died of pneumonia due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection1. This was the first coronavirus disease 19 (COVID-19)-related death detected in Italy since the detection of SARS-CoV-2 in the Chinese city of Wuhan, Hubei province2. In response, the regional authorities imposed the lockdown of the whole municipality for 14 days3. Here we collected information on the demography, clinical presentation, hospitalization, contact network and the presence of SARS-CoV-2 infection in nasopharyngeal swabs for 85.9% and 71.5% of the population of Vo’ at two consecutive time points. From the first survey, which was conducted around the time the town lockdown started, we found a prevalence of infection of 2.6% (95% confidence interval (CI): 2.1–3.3%). From the second survey, which was conducted at the end of the lockdown, we found a prevalence of 1.2% (95% CI: 0.8–1.8%). Notably, 42.5% (95% CI: 31.5–54.6%) of the confirmed SARS-CoV-2 infections detected across the two surveys were asymptomatic (that is, did not have symptoms at the time of swab testing and did not develop symptoms afterwards). The mean serial interval was 7.2 days (95% CI: 5.9–9.6). We found no statistically significant difference in the viral load of symptomatic versus asymptomatic infections (P = 0.62 and 0.74 for E and RdRp genes, respectively, exact Wilcoxon–Mann–Whitney test). This study sheds light on the frequency of asymptomatic SARS-CoV-2 infection, their infectivity (as measured by the viral load) and provides insights into its transmission dynamics and the efficacy of the implemented control measures.

Suggested Citation

  • Enrico Lavezzo & Elisa Franchin & Constanze Ciavarella & Gina Cuomo-Dannenburg & Luisa Barzon & Claudia Del Vecchio & Lucia Rossi & Riccardo Manganelli & Arianna Loregian & Nicolò Navarin & Davide Aba, 2020. "Suppression of a SARS-CoV-2 outbreak in the Italian municipality of Vo’," Nature, Nature, vol. 584(7821), pages 425-429, August.
    • Handle: RePEc:nat:nature:v:584:y:2020:i:7821:d:10.1038_s41586-020-2488-1
    DOI: 10.1038/s41586-020-2488-1
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    Citations

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    Cited by:

    1. Beatrice Casati & Joseph Peter Verdi & Alexander Hempelmann & Maximilian Kittel & Andrea Gutierrez Klaebisch & Bianca Meister & Sybille Welker & Sonal Asthana & Salvatore Giorgio & Pavle Boskovic & Ka, 2022. "Rapid, adaptable and sensitive Cas13-based COVID-19 diagnostics using ADESSO," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Bello, Piera & Rocco, Lorenzo, 2022. "Education and COVID-19 excess mortality," Economics & Human Biology, Elsevier, vol. 47(C).
    3. Antoci, Angelo & Sabatini, Fabio & Sacco, Pier Luigi & Sodini, Mauro, 2022. "Experts vs. policymakers in the COVID-19 policy response," Journal of Economic Behavior & Organization, Elsevier, vol. 201(C), pages 22-39.
    4. Christiaan H. van Dorp & Emma E. Goldberg & Nick Hengartner & Ruian Ke & Ethan O. Romero-Severson, 2021. "Estimating the strength of selection for new SARS-CoV-2 variants," Nature Communications, Nature, vol. 12(1), pages 1-13, December.
    5. Claudia Del Vecchio & Bethan Cracknell Daniels & Giuseppina Brancaccio & Alessandra Rosalba Brazzale & Enrico Lavezzo & Constanze Ciavarella & Francesco Onelia & Elisa Franchin & Laura Manuto & Federi, 2022. "Impact of antigen test target failure and testing strategies on the transmission of SARS-CoV-2 variants," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    6. Bosa, Iris & Castelli, Adriana & Castelli, Michele & Ciani, Oriani & Compagni, Amelia & Galizzi, Matteo M. & Garofano, Matteo & Ghislandi, Simone & Giannoni, Margherita & Marini, Giorgia & Vainieri, M, 2021. "Corona-regionalism? Differences in regional responses to COVID-19 in Italy," Health Policy, Elsevier, vol. 125(9), pages 1179-1187.

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