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Translational research: Crossing the valley of death

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  • Declan Butler

Abstract

A chasm has opened up between biomedical researchers and the patients who need their discoveries. Declan Butler asks how the ground shifted and whether the US National Institutes of Health can bridge the gap.

Suggested Citation

  • Declan Butler, 2008. "Translational research: Crossing the valley of death," Nature, Nature, vol. 453(7197), pages 840-842, June.
    • Handle: RePEc:nat:nature:v:453:y:2008:i:7197:d:10.1038_453840a
    DOI: 10.1038/453840a
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    Cited by:

    1. Mulligan, Kevin & Lenihan, Helena & Doran, Justin & Roper, Stephen, 2022. "Harnessing the science base: Results from a national programme using publicly-funded research centres to reshape firms’ R&D," Research Policy, Elsevier, vol. 51(4).
    2. Bonnín Roca, Jaime & Vaishnav, Parth & Morgan, Granger M. & Fuchs, Erica & Mendonça, Joana, 2021. "Technology Forgiveness: Why emerging technologies differ in their resilience to institutional instability," Technological Forecasting and Social Change, Elsevier, vol. 166(C).
    3. Alex Coad & Agustí Segarra-Blasco & Mercedes Teruel, 2021. "A bit of basic, a bit of applied? R&D strategies and firm performance," The Journal of Technology Transfer, Springer, vol. 46(6), pages 1758-1783, December.
    4. Chia-Hui Chen & Junichiro Ishida & Wing Suen, 2021. "Reputation Concerns in Risky Experimentation [Reputation and Survival: Learning in a Dynamic Signalling Model]," Journal of the European Economic Association, European Economic Association, vol. 19(4), pages 1981-2021.
    5. Azoulay, Pierre & Greenblatt, Wesley H. & Heggeness, Misty L., 2021. "Long-term effects from early exposure to research: Evidence from the NIH “Yellow Berets”," Research Policy, Elsevier, vol. 50(9).
    6. Chen, Chia-Hui & Ishida, Junichiro, 2018. "Hierarchical experimentation," Journal of Economic Theory, Elsevier, vol. 177(C), pages 365-404.
    7. Watzinger, Martin & Schnitzer, Monika, 2019. "Standing on the Shoulders of Science," Rationality and Competition Discussion Paper Series 215, CRC TRR 190 Rationality and Competition.
    8. Chia-Hui Chen & Junichiro Ishida & Wing Suen, 2019. "Reputation Concerns in Risky Experimentation," ISER Discussion Paper 1060, Institute of Social and Economic Research, Osaka University.
    9. Ke, Qing, 2020. "The citation disadvantage of clinical research," Journal of Informetrics, Elsevier, vol. 14(1).
    10. Ute Laermann-Nguyen & Martin Backfisch, 2021. "Innovation crisis in the pharmaceutical industry? A survey," SN Business & Economics, Springer, vol. 1(12), pages 1-37, December.
    11. Morgan, Myfanwy & Barry, Christine A. & Donovan, Jenny L. & Sandall, Jane & Wolfe, Charles D.A. & Boaz, Annette, 2011. "Implementing ‘translational’ biomedical research: Convergence and divergence among clinical and basic scientists," Social Science & Medicine, Elsevier, vol. 73(7), pages 945-952.
    12. Marguin, Séverine & Haus, Juliane & Heinrich, Anna Juliane & Kahl, Antje & Schendzielorz, Cornelia & Singh, Ajit, 2021. "Positionality Reloaded: Debating the Dimensions of Reflexivity in the Relationship Between Science and Society: An Editorial," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 46(2), pages 7-34.
    13. Daniel P. Gross & Bhaven N. Sampat, 2022. "Crisis Innovation Policy from World War II to COVID-19," Entrepreneurship and Innovation Policy and the Economy, University of Chicago Press, vol. 1(1), pages 135-181.
    14. Tim Hulsen, 2020. "Sharing Is Caring—Data Sharing Initiatives in Healthcare," IJERPH, MDPI, vol. 17(9), pages 1-12, April.
    15. Yeon Hak Kim & Aaron D. Levine & Eric J. Nehl & John P. Walsh, 2020. "A bibliometric measure of translational science," Scientometrics, Springer;Akadémiai Kiadó, vol. 125(3), pages 2349-2382, December.
    16. Clemens Blümel, 2018. "Translational research in the science policy debate: a comparative analysis of documents," Science and Public Policy, Oxford University Press, vol. 45(1), pages 24-35.
    17. Erik Aarden & Luca Marelli & Alessandro Blasimme, 2021. "The translational lag narrative in policy discourse in the United States and the European Union: a comparative study," Palgrave Communications, Palgrave Macmillan, vol. 8(1), pages 1-9, December.
    18. Massaro, Maurizio, 2023. "Digital transformation in the healthcare sector through blockchain technology. Insights from academic research and business developments," Technovation, Elsevier, vol. 120(C).
    19. Liang (Leon) Xu & Hui Zhao & Nicholas C. Petruzzi, 2021. "Inducing Compliance with Postmarket Studies for Drugs Under FDA’s Accelerated Approval Pathway," Manufacturing & Service Operations Management, INFORMS, vol. 23(1), pages 170-190, 1-2.
    20. Currie, Graeme & El Enany, Nellie & Lockett, Andy, 2014. "Intra-professional dynamics in translational health research: The perspective of social scientists," Social Science & Medicine, Elsevier, vol. 114(C), pages 81-88.
    21. Sang-Min Park & Nicholas S. Vonortas, 2023. "Translational research: from basic research to regional biomedical entrepreneurship," Small Business Economics, Springer, vol. 60(4), pages 1761-1783, April.
    22. Elise M. R. Smith & Stephen Molldrem & Jeffrey S. Farroni & Emma Tumilty, 2024. "Articulating the social responsibilities of translational science," Palgrave Communications, Palgrave Macmillan, vol. 11(1), pages 1-13, December.
    23. Vittori, Davide & Natalicchio, Angelo & Panniello, Umberto & Messeni Petruzzelli, Antonio & Cupertino, Francesco, 2022. "Business Model Innovation between the embryonic and growth stages of industry lifecycle," Technovation, Elsevier, vol. 117(C).
    24. Bonnin Roca, Jaime & O'Sullivan, Eoin, 2022. "The role of regulators in mitigating uncertainty within the Valley of Death," Technovation, Elsevier, vol. 109(C).

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