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Genetics of body-weight regulation

Author

Listed:
  • Gregory S. Barsh

    (Beckman Center)

  • I. Sadaf Farooqi

    (University of Cambridge, Addenbrooke's Hospital)

  • Stephen O'Rahilly

    (University of Cambridge, Addenbrooke's Hospital)

Abstract

The role of genetics in obesity is twofold. Studying rare mutations in humans and model organisms provides fundamental insight into a complex physiological process, and complements population-based studies that seek to reveal primary causes. Remarkable progress has been made on both fronts, and the pace of advance is likely to accelerate as functional genomics and the human genome project expand and mature. Approaches based on mendelian and quantitative genetics may well converge, and lead ultimately to more rational and selective therapies.

Suggested Citation

  • Gregory S. Barsh & I. Sadaf Farooqi & Stephen O'Rahilly, 2000. "Genetics of body-weight regulation," Nature, Nature, vol. 404(6778), pages 644-651, April.
    • Handle: RePEc:nat:nature:v:404:y:2000:i:6778:d:10.1038_35007519
    DOI: 10.1038/35007519
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    Cited by:

    1. Smith Trenton G. & Stoddard Christiana & Barnes Michael G, 2009. "Why the Poor Get Fat: Weight Gain and Economic Insecurity," Forum for Health Economics & Policy, De Gruyter, vol. 12(2), pages 1-31, June.
    2. Trenton Smith, 2009. "Reconciling psychology with economics: Obesity, behavioral biology, and rational overeating," Journal of Bioeconomics, Springer, vol. 11(3), pages 249-282, December.
    3. Jennifer MacKellar & Samuel W Cushman & Vipul Periwal, 2010. "Waves of Adipose Tissue Growth in the Genetically Obese Zucker Fatty Rat," PLOS ONE, Public Library of Science, vol. 5(1), pages 1-9, January.
    4. Smith, Trenton G, 2002. "Obesity and Nature's Thumbprint: How Modern Waistlines Can Inform Economic Theory," University of California at Santa Barbara, Economics Working Paper Series qt31g1m028, Department of Economics, UC Santa Barbara.
    5. Brown, Judith E. & Broom, Dorothy H. & Nicholson, Jan M. & Bittman, Michael, 2010. "Do working mothers raise couch potato kids? Maternal employment and children's lifestyle behaviours and weight in early childhood," Social Science & Medicine, Elsevier, vol. 70(11), pages 1816-1824, June.
    6. Dang, Thang, 2017. "Body Weight and Hypertension Risk in a Developing Country," MPRA Paper 83182, University Library of Munich, Germany.

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