IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v15y2024i1d10.1038_s41467-024-47358-6.html
   My bibliography  Save this article

Origin and dispersal history of Hepatitis B virus in Eastern Eurasia

Author

Listed:
  • Bing Sun

    (Jilin University)

  • Aida Andrades Valtueña

    (Max Planck Institute for Evolutionary Anthropology)

  • Arthur Kocher

    (Max Planck Institute for Evolutionary Anthropology
    Max Planck Institute for the Science of Human History)

  • Shizhu Gao

    (Jilin University)

  • Chunxiang Li

    (Jilin University)

  • Shuang Fu

    (Jilin University)

  • Fan Zhang

    (Jilin University)

  • Pengcheng Ma

    (Jilin University)

  • Xuan Yang

    (Jilin University)

  • Yulan Qiu

    (Jilin University)

  • Quanchao Zhang

    (Jilin University)

  • Jian Ma

    (Northwest University)

  • Shan Chen

    (Liaoning University)

  • Xiaoming Xiao

    (Liaoning University)

  • Sodnomjamts Damchaabadgar

    (Institute of Archaeology Mongolian Academy of Sciences)

  • Fajun Li

    (Sun Yat-sen University)

  • Alexey Kovalev

    (Institute of Archaeology of Russian Academy of Sciences)

  • Chunbai Hu

    (Inner Mongolia Autonomous Region)

  • Xianglong Chen

    (Chinese Academy of Social Sciences)

  • Lixin Wang

    (Jilin University)

  • Wenying Li

    (Xinjiang Institute of Cultural Relics and Archaeology)

  • Yawei Zhou

    (Zhengzhou University)

  • Hong Zhu

    (Jilin University)

  • Johannes Krause

    (Max Planck Institute for Evolutionary Anthropology)

  • Alexander Herbig

    (Max Planck Institute for Evolutionary Anthropology)

  • Yinqiu Cui

    (Jilin University)

Abstract

Hepatitis B virus is a globally distributed pathogen and the history of HBV infection in humans predates 10000 years. However, long-term evolutionary history of HBV in Eastern Eurasia remains elusive. We present 34 ancient HBV genomes dating between approximately 5000 to 400 years ago sourced from 17 sites across Eastern Eurasia. Ten sequences have full coverage, and only two sequences have less than 50% coverage. Our results suggest a potential origin of genotypes B and D in Eastern Asia. We observed a higher level of HBV diversity within Eastern Eurasia compared to Western Eurasia between 5000 and 3000 years ago, characterized by the presence of five different genotypes (A, B, C, D, WENBA), underscoring the significance of human migrations and interactions in the spread of HBV. Our results suggest the possibility of a transition from non-recombinant subgenotypes (B1, B5) to recombinant subgenotypes (B2 - B4). This suggests a shift in epidemiological dynamics within Eastern Eurasia over time. Here, our study elucidates the regional origins of prevalent genotypes and shifts in viral subgenotypes over centuries.

Suggested Citation

  • Bing Sun & Aida Andrades Valtueña & Arthur Kocher & Shizhu Gao & Chunxiang Li & Shuang Fu & Fan Zhang & Pengcheng Ma & Xuan Yang & Yulan Qiu & Quanchao Zhang & Jian Ma & Shan Chen & Xiaoming Xiao & So, 2024. "Origin and dispersal history of Hepatitis B virus in Eastern Eurasia," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47358-6
    DOI: 10.1038/s41467-024-47358-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-024-47358-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-024-47358-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Peter Barros Damgaard & Nina Marchi & Simon Rasmussen & Michael Peyrot & Gabriel Renaud & Thorfinn Korneliussen & J. Victor Moreno-Mayar & Mikkel Winther Pedersen & Amy Goldberg & Emma Usmanova & Nurb, 2018. "Author Correction: 137 ancient human genomes from across the Eurasian steppes," Nature, Nature, vol. 563(7729), pages 16-16, November.
    2. Iosif Lazaridis & Dani Nadel & Gary Rollefson & Deborah C. Merrett & Nadin Rohland & Swapan Mallick & Daniel Fernandes & Mario Novak & Beatriz Gamarra & Kendra Sirak & Sarah Connell & Kristin Stewards, 2016. "Genomic insights into the origin of farming in the ancient Near East," Nature, Nature, vol. 536(7617), pages 419-424, August.
    3. Fan Zhang & Chao Ning & Ashley Scott & Qiaomei Fu & Rasmus Bjørn & Wenying Li & Dong Wei & Wenjun Wang & Linyuan Fan & Idilisi Abuduresule & Xingjun Hu & Qiurong Ruan & Alipujiang Niyazi & Guanghui Do, 2021. "The genomic origins of the Bronze Age Tarim Basin mummies," Nature, Nature, vol. 599(7884), pages 256-261, November.
    4. Barbara Muhlemann & Terry C. Jones & Peter Barros Damgaard & Morten E. Allentoft & Irina Shevnina & Andrey Logvin & Emma Usmanova & Irina P. Panyushkina & Bazartseren Boldgiv & Tsevel Bazartseren & Ka, 2018. "Author Correction: Ancient hepatitis B viruses from the Bronze Age to the Medieval period," Nature, Nature, vol. 562(7726), pages 4-4, October.
    5. Barbara Mühlemann & Terry C. Jones & Peter de Barros Damgaard & Morten E. Allentoft & Irina Shevnina & Andrey Logvin & Emma Usmanova & Irina P. Panyushkina & Bazartseren Boldgiv & Tsevel Bazartseren &, 2018. "Ancient hepatitis B viruses from the Bronze Age to the Medieval period," Nature, Nature, vol. 557(7705), pages 418-423, May.
    6. Chao Ning & Tianjiao Li & Ke Wang & Fan Zhang & Tao Li & Xiyan Wu & Shizhu Gao & Quanchao Zhang & Hai Zhang & Mark J. Hudson & Guanghui Dong & Sihao Wu & Yanming Fang & Chen Liu & Chunyan Feng & Wei L, 2020. "Ancient genomes from northern China suggest links between subsistence changes and human migration," Nature Communications, Nature, vol. 11(1), pages 1-9, December.
    7. Thiseas C. Lamnidis & Kerttu Majander & Choongwon Jeong & Elina Salmela & Anna Wessman & Vyacheslav Moiseyev & Valery Khartanovich & Oleg Balanovsky & Matthias Ongyerth & Antje Weihmann & Antti Sajant, 2018. "Ancient Fennoscandian genomes reveal origin and spread of Siberian ancestry in Europe," Nature Communications, Nature, vol. 9(1), pages 1-12, December.
    8. Liu, Xinru, 2010. "The Silk Road in World History," OUP Catalogue, Oxford University Press, number 9780195338102.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Chi-Chun Liu & David Witonsky & Anna Gosling & Ju Hyeon Lee & Harald Ringbauer & Richard Hagan & Nisha Patel & Raphaela Stahl & John Novembre & Mark Aldenderfer & Christina Warinner & Anna Di Rienzo &, 2022. "Ancient genomes from the Himalayas illuminate the genetic history of Tibetans and their Tibeto-Burman speaking neighbors," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Selina Carlhoff & Wibhu Kutanan & Adam B. Rohrlach & Cosimo Posth & Mark Stoneking & Kathrin Nägele & Rasmi Shoocongdej & Johannes Krause, 2023. "Genomic portrait and relatedness patterns of the Iron Age Log Coffin culture in northwestern Thailand," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    3. Pei-Kuan Cong & Wei-Yang Bai & Jin-Chen Li & Meng-Yuan Yang & Saber Khederzadeh & Si-Rui Gai & Nan Li & Yu-Heng Liu & Shi-Hui Yu & Wei-Wei Zhao & Jun-Quan Liu & Yi Sun & Xiao-Wei Zhu & Pian-Pian Zhao , 2022. "Genomic analyses of 10,376 individuals in the Westlake BioBank for Chinese (WBBC) pilot project," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Alieh Abadi & Mehdi Khakzand, 2022. "Extracting the qualitative dimensions of agritourism for the sustainable development of Charqoli village in Iran: the promotion of vernacular entrepreneurship and environment-oriented preservation per," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 24(11), pages 12609-12671, November.
    5. Lixiong Xiang & Xiaozhong Huang & Mingjie Sun & Virginia N. Panizzo & Chong Huang & Min Zheng & Xuemei Chen & Fahu Chen, 2023. "Prehistoric population expansion in Central Asia promoted by the Altai Holocene Climatic Optimum," Nature Communications, Nature, vol. 14(1), pages 1-9, December.
    6. Zhen Wang & Xiaokang Liu & Haichao Xie & Shengqian Chen & Jianhui Chen & Haipeng Wang & Meihong Ma & Fahu Chen, 2024. "Time-Transgressive Onset of Holocene Climate Optimum in Arid Central Asia and Its Association with Cultural Exchanges," Land, MDPI, vol. 13(3), pages 1-18, March.
    7. Markku Oinonen & Teija Alenius & Laura Arppe & Hervé Bocherens & Heli Etu-Sihvola & Samuli Helama & Heli Huhtamaa & Maria Lahtinen & Kristiina Mannermaa & Päivi Onkamo & Jukka Palo & Antti Sajantila &, 2020. "Buried in water, burdened by nature—Resilience carried the Iron Age people through Fimbulvinter," PLOS ONE, Public Library of Science, vol. 15(4), pages 1-27, April.
    8. Maciej Chyleński & Przemysław Makarowicz & Anna Juras & Maja Krzewińska & Łukasz Pospieszny & Edvard Ehler & Agnieszka Breszka & Jacek Górski & Halina Taras & Anita Szczepanek & Marta Polańska & Piotr, 2023. "Patrilocality and hunter-gatherer-related ancestry of populations in East-Central Europe during the Middle Bronze Age," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    9. Guimel Hernández-Garay, 2018. "Consumption of Chinese silk fabrics in Marseille and Seville, 1680 – 1840," Working Papers 18.01, Universidad Pablo de Olavide, Department of Economics, Quantitative Methods and Economic History.
    10. Xiaofang Ma & Xingjun Hu & Menghan Qiu, 2024. "Radiocarbon-Refined Archaeological Chronology and the History of Human Activity in the Southern Tarim Basin," Land, MDPI, vol. 13(4), pages 1-14, April.
    11. Maryam Mahmoodi & Michał Roman & Piotr Prus, 2022. "Features and Challenges of Agritourism: Evidence from Iran and Poland," Sustainability, MDPI, vol. 14(8), pages 1-20, April.
    12. Ansofino, Anas & Zusmelia, Zubir, 2023. "Global Competitiveness of Trade in the West Coast of Sumatra from the Perspective of the Agglomeration of Economic Approach," AGRIS on-line Papers in Economics and Informatics, Czech University of Life Sciences Prague, Faculty of Economics and Management, vol. 15(2), June.
    13. Andrea Quagliariello & Alessandra Modi & Gabriel Innocenti & Valentina Zaro & Cecilia Conati Barbaro & Annamaria Ronchitelli & Francesco Boschin & Claudio Cavazzuti & Elena Dellù & Francesca Radina & , 2022. "Ancient oral microbiomes support gradual Neolithic dietary shifts towards agriculture," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    14. George Cornel Dumitrescu, 2019. "Could Romania become a trade hub on the TEN-T and the Belt and Road initiative," Global Economic Observer, "Nicolae Titulescu" University of Bucharest, Faculty of Economic Sciences;Institute for World Economy of the Romanian Academy, vol. 7(1), June.
    15. Leonardo Vallini & Carlo Zampieri & Mohamed Javad Shoaee & Eugenio Bortolini & Giulia Marciani & Serena Aneli & Telmo Pievani & Stefano Benazzi & Alberto Barausse & Massimo Mezzavilla & Michael D. Pet, 2024. "The Persian plateau served as hub for Homo sapiens after the main out of Africa dispersal," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    16. Rozaimi Mohamad Razali & Juan Rodriguez-Flores & Mohammadmersad Ghorbani & Haroon Naeem & Waleed Aamer & Elbay Aliyev & Ali Jubran & Andrew G. Clark & Khalid A. Fakhro & Younes Mokrab, 2021. "Thousands of Qatari genomes inform human migration history and improve imputation of Arab haplotypes," Nature Communications, Nature, vol. 12(1), pages 1-16, December.
    17. Javier G. Serrano & Alejandra C. Ordóñez & Jonathan Santana & Elías Sánchez-Cañadillas & Matilde Arnay & Amelia Rodríguez-Rodríguez & Jacob Morales & Javier Velasco-Vázquez & Verónica Alberto-Barroso , 2023. "The genomic history of the indigenous people of the Canary Islands," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    18. Mihajlo Jakovljevic & Arcadio A. Cerda & Yansui Liu & Leidy García & Yuriy Timofeyev & Kristijan Krstic & John Fontanesi, 2021. "Sustainability Challenge of Eastern Europe—Historical Legacy, Belt and Road Initiative, Population Aging and Migration," Sustainability, MDPI, vol. 13(19), pages 1-18, October.
    19. Douglas J. Kennett & Mark Lipson & Keith M. Prufer & David Mora-Marín & Richard J. George & Nadin Rohland & Mark Robinson & Willa R. Trask & Heather H. J. Edgar & Ethan C. Hill & Erin E. Ray & Paige L, 2022. "South-to-north migration preceded the advent of intensive farming in the Maya region," Nature Communications, Nature, vol. 13(1), pages 1-10, December.
    20. Sárvári Balázs & Szeidovitz Anna, 2016. "The Political Economics of the New Silk Road," TalTech Journal of European Studies, Sciendo, vol. 6(1), pages 3-27, February.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:15:y:2024:i:1:d:10.1038_s41467-024-47358-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.