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Long-term health impacts of COVID-19 among 242,712 adults in England

Author

Listed:
  • Christina J. Atchison

    (Imperial College London
    Imperial College Healthcare NHS Trust)

  • Bethan Davies

    (Imperial College London
    Imperial College Healthcare NHS Trust
    Imperial College London)

  • Emily Cooper

    (Imperial College London)

  • Adam Lound

    (Imperial College London)

  • Matthew Whitaker

    (Imperial College London
    Imperial College London)

  • Adam Hampshire

    (Imperial College London)

  • Adriana Azor

    (Imperial College London)

  • Christl A. Donnelly

    (Imperial College London
    University of Oxford
    MRC Centre for Global infectious Disease Analysis and Abdul Latif Jameel Institute for Disease and Emergency Analytics, Imperial College London)

  • Marc Chadeau-Hyam

    (Imperial College London
    Health Data Research (HDR) UK London at Imperial College)

  • Graham S. Cooke

    (Imperial College Healthcare NHS Trust
    Imperial College London
    National Institute for Health Research Imperial Biomedical Research Centre)

  • Helen Ward

    (Imperial College London
    Imperial College Healthcare NHS Trust
    MRC Centre for Global infectious Disease Analysis and Abdul Latif Jameel Institute for Disease and Emergency Analytics, Imperial College London
    National Institute for Health Research Imperial Biomedical Research Centre)

  • Paul Elliott

    (Imperial College London
    Imperial College Healthcare NHS Trust
    Imperial College London
    Health Data Research (HDR) UK London at Imperial College)

Abstract

The COVID-19 pandemic is having a lasting impact on health and well-being. We compare current self-reported health, quality of life and symptom profiles for people with ongoing symptoms following COVID-19 to those who have never tested positive for SARS-CoV-2 infection and those who have recovered from COVID-19. Overall, 276,840/800,000 (34·6%) of invited participants took part. Mental health and health-related quality of life were worse among participants with ongoing persistent symptoms post-COVID compared with those who had never had COVID-19 or had recovered. In this study, median duration of COVID-related symptoms (N = 130,251) was 1·3 weeks (inter-quartile range 6 days to 2 weeks), with 7·5% and 5·2% reporting ongoing symptoms ≥12 weeks and ≥52 weeks respectively. Female sex, ≥1 comorbidity and being infected when Wild-type variant was dominant were associated with higher probability of symptoms lasting ≥12 weeks and longer recovery time in those with persistent symptoms. Although COVID-19 is usually of short duration, some adults experience persistent and burdensome illness.

Suggested Citation

  • Christina J. Atchison & Bethan Davies & Emily Cooper & Adam Lound & Matthew Whitaker & Adam Hampshire & Adriana Azor & Christl A. Donnelly & Marc Chadeau-Hyam & Graham S. Cooke & Helen Ward & Paul Ell, 2023. "Long-term health impacts of COVID-19 among 242,712 adults in England," Nature Communications, Nature, vol. 14(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-41879-2
    DOI: 10.1038/s41467-023-41879-2
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    References listed on IDEAS

    as
    1. Ellen J. Thompson & Dylan M. Williams & Alex J. Walker & Ruth E. Mitchell & Claire L. Niedzwiedz & Tiffany C. Yang & Charlotte F. Huggins & Alex S. F. Kwong & Richard J. Silverwood & Giorgio Di Gessa , 2022. "Long COVID burden and risk factors in 10 UK longitudinal studies and electronic health records," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    2. Min Du & Yirui Ma & Jie Deng & Min Liu & Jue Liu, 2022. "Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(23), pages 1-15, November.
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