IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v13y2022i1d10.1038_s41467-022-33819-3.html
   My bibliography  Save this article

Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2

Author

Listed:
  • Young Rae Ji

    (National Institutes of Health
    Sensory & Motor Systems Research Group, Korea Brain Research Institute (KBRI))

  • Yosuke Tona

    (National Institutes of Health
    Otolaryngology/Head and Neck Surgery, Kyoto University Hospital)

  • Talah Wafa

    (National Institutes of Health)

  • Matthew E. Christman

    (Johns Hopkins University School of Medicine)

  • Edward D. Tourney

    (Johns Hopkins University School of Medicine)

  • Tao Jiang

    (National Institutes of Health
    Fudan University)

  • Sho Ohta

    (National Institutes of Health)

  • Hui Cheng

    (National Institutes of Health)

  • Tracy Fitzgerald

    (National Institutes of Health)

  • Bernd Fritzsch

    (University of Iowa)

  • Sherri M. Jones

    (University of Nebraska-Lincoln)

  • Kathleen E. Cullen

    (Johns Hopkins University School of Medicine)

  • Doris K. Wu

    (National Institutes of Health)

Abstract

Otolith organs of the inner ear are innervated by two parallel afferent projections to the brainstem and cerebellum. These innervations were proposed to segregate across the line of polarity reversal (LPR) within each otolith organ, which divides the organ into two regions of hair cells (HC) with opposite stereociliary orientation. The relationship and functional significance of these anatomical features are not known. Here, we show regional expression of Emx2 in otolith organs, which establishes LPR, mediates the neuronal segregation across LPR and constitutes the bidirectional sensitivity function. Conditional knockout (cKO) of Emx2 in HCs lacks LPR. Tmie cKO, in which mechanotransduction was abolished selectively in HCs within the Emx2 expression domain also lacks bidirectional sensitivity. Analyses of both mutants indicate that LPR is specifically required for mice to swim comfortably and to traverse a balance beam efficiently, but LPR is not required for mice to stay on a rotating rod.

Suggested Citation

  • Young Rae Ji & Yosuke Tona & Talah Wafa & Matthew E. Christman & Edward D. Tourney & Tao Jiang & Sho Ohta & Hui Cheng & Tracy Fitzgerald & Bernd Fritzsch & Sherri M. Jones & Kathleen E. Cullen & Doris, 2022. "Function of bidirectional sensitivity in the otolith organs established by transcription factor Emx2," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33819-3
    DOI: 10.1038/s41467-022-33819-3
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-33819-3
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-33819-3?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Pena, Edsel A. & Slate, Elizabeth H., 2006. "Global Validation of Linear Model Assumptions," Journal of the American Statistical Association, American Statistical Association, vol. 101, pages 341-354, March.
    2. Kazuya Ono & James Keller & Omar López Ramírez & Antonia González Garrido & Omid A. Zobeiri & Hui Ho Vanessa Chang & Sarath Vijayakumar & Andrianna Ayiotis & Gregg Duester & Charles C. Della Santina &, 2020. "Retinoic acid degradation shapes zonal development of vestibular organs and sensitivity to transient linear accelerations," Nature Communications, Nature, vol. 11(1), pages 1-15, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Zhikai Liu & David G. C. Hildebrand & Joshua L. Morgan & Yizhen Jia & Nicholas Slimmon & Martha W. Bagnall, 2022. "Organization of the gravity-sensing system in zebrafish," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Herziger, Atar & Claborn, Kelly A. & Brooks, Jeremy S., 2020. "Is There Hope for the Double Dividend? How Social Context Can Shape Synergies and Tradeoffs between Sustainable Consumption and Well-Being," Ecological Economics, Elsevier, vol. 176(C).
    3. Gomes Adriana Maria Silva & de Sousa Paulo Sérgio Amaral & Moreira Maria do Rosário Alves, 2023. "Having a better environmental performance translates into a better financial performance: A study of the European food industry," Environmental & Socio-economic Studies, Sciendo, vol. 11(3), pages 1-13, September.
    4. Weichen Wu & Nynke Niezink & Brian Junker, 2022. "A diagnostic framework for the Bradley–Terry model," Journal of the Royal Statistical Society Series A, Royal Statistical Society, vol. 185(S2), pages 461-484, December.
    5. Barrientos, Andrés F. & Canale, Antonio, 2021. "A Bayesian goodness-of-fit test for regression," Computational Statistics & Data Analysis, Elsevier, vol. 155(C).
    6. Merton S. Krause, 2018. "Associational versus correlational research study design and data analysis," Quality & Quantity: International Journal of Methodology, Springer, vol. 52(6), pages 2691-2707, November.
    7. Vos, F.G.S. & Van der Lelij, R. & Schiele, H. & Praas, N.H.J., 2021. "Mediating the impact of power on supplier satisfaction: Do buyer status and relational conflict matter?," International Journal of Production Economics, Elsevier, vol. 239(C).
    8. Valeva, Silviya & Hewitt, Mike & Thomas, Barrett W. & Brown, Kenneth G., 2017. "Balancing flexibility and inventory in workforce planning with learning," International Journal of Production Economics, Elsevier, vol. 183(PA), pages 194-207.
    9. Francesc Belvis & Mireia Bolíbar & Joan Benach & Mireia Julià, 2022. "Precarious Employment and Chronic Stress: Do Social Support Networks Matter?," IJERPH, MDPI, vol. 19(3), pages 1-14, February.
    10. Paul McKeown & Gillis Maclean, 2013. "Is activity in online quizzes correlated with higher exam marks?," New Zealand Economic Papers, Taylor & Francis Journals, vol. 47(3), pages 276-287, December.
    11. Abdallah S. A. Yaseen, 2022. "Impact of social determinants on COVID-19 infections: a comprehensive study from Saudi Arabia governorates," Palgrave Communications, Palgrave Macmillan, vol. 9(1), pages 1-9, December.
    12. Qiang B & Abdalla A & Morgan S & Hashemi P & Peña E, 2019. "Estimating Concentration Response Function and Change-Point using Time-Course and Calibration Data," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 9(3), pages 57-68, March.
    13. Ester Gutiérrez & Sebastián Lozano, 2022. "Cross-country comparison of the efficiency of the European forest sector and second stage DEA approach," Annals of Operations Research, Springer, vol. 314(2), pages 471-496, July.
    14. Angela Ramnarine Rieks & Jason Dedrick & Jeffrey Stanton, 2020. "Risks, benefits, and control of information: Two studies of smart electric meter privacy," Journal of the Association for Information Science & Technology, Association for Information Science & Technology, vol. 71(9), pages 1060-1073, September.
    15. Piotr Skórka & Beata Grzywacz & Dawid Moroń & Magdalena Lenda, 2022. "COVID-19 in Memes: The Adaptive Response of Societies to the Pandemic?," IJERPH, MDPI, vol. 19(19), pages 1-24, October.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-33819-3. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.