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Older Adults Who Maintained a Regular Physical Exercise Routine before the Pandemic Show Better Immune Response to Vaccination for COVID-19

Author

Listed:
  • Brenda Rodrigues Silva

    (Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Fernanda Rodrigues Monteiro

    (Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Kizzy Cezário

    (Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Jônatas Bussador do Amaral

    (ENT Research Lab., Department of Otorhinolaryngology—Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil)

  • Vitória Paixão

    (ENT Research Lab., Department of Otorhinolaryngology—Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil)

  • Ewin Barbosa Almeida

    (ENT Research Lab., Department of Otorhinolaryngology—Head and Neck Surgery, Federal University of Sao Paulo (UNIFESP), São Paulo 04021-001, Brazil)

  • Carlos André Freitas dos Santos

    (Discipline of Geriatrics and Gerontology, Department of Medicine, Paulista School of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo 04020-050, Brazil
    Postgraduate Program in Translational Medicine, Department of Medicine, Paulista School of Medicine, Federal University of São Paulo (UNIFESP), São Paulo 04023-062, Brazil)

  • Gislene Rocha Amirato

    (Mane Garrincha Sports Education Center, Sports Department of the Municipality of Sao Paulo (SEME), São Paulo 04039-034, Brazil)

  • Danielle Bruna Leal Oliveira

    (Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil
    Laboratory of Clinical and Molecular Virology, Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-060, Brazil)

  • Edison Luiz Durigon

    (Laboratory of Clinical and Molecular Virology, Department of Microbiology, Institute of Biomedical Science, University of São Paulo, São Paulo 05508-060, Brazil
    Scientific Platform Pasteur, University of São Paulo, São Paulo 05508-060, Brazil)

  • Andressa Simões Aguiar

    (Scientific Platform Pasteur, University of São Paulo, São Paulo 05508-060, Brazil
    Infection Control Service, São Luiz Gonzaga Hospital of Santa Casa de Misericordia of São Paulo, São Paulo 02276-140, Brazil)

  • Rodolfo P. Vieira

    (Post-graduate Program in Human Movement and Rehabilitation and in Pharmaceutical Sciences, Universidade Evangélica de Goiás (Unievangelica), Av Universitária km 3,5, Anápolis-Go 75083-515, Brazil)

  • Juliana de Melo Batista dos Santos

    (Department of Physical Therapy, School of Medicine, University of São Paulo, São Paulo 05360-000, Brazil)

  • Guilherme Eustáquio Furtado

    (Polytechnic Institute of Coimbra, Applied Research Institute, Rua da Misericórdia, Lagar dos Cortiços—S. Martinho do Bispo, 3045-093 Coimbra, Portugal)

  • Carolina Nunes França

    (Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • Marina Tiemi Shio

    (Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

  • André Luis Lacerda Bachi

    (Post-Graduation Program in Health Sciences, Santo Amaro University (UNISA), São Paulo 04829-300, Brazil)

Abstract

Background: In this study, we aimed to investigate the specific-antibody response to the COVID-19 vaccination and the immunophenotyping of T cells in older adults who were engaged or not in an exercise training program before the pandemic. Methods: Ninety-three aged individuals (aged between 60 and 85 years) were separated into 3 groups: practitioners of physical exercise vaccinated with CoronaVac (PE-Co, n = 46), or vaccinated with ChadOx-1 (PE-Ch, n = 23), and non-practitioners vaccinated with ChadOx-1 (NPE-Ch, n = 24). Blood samples were collected before (pre) and 30 days after vaccination with the second vaccine dose. Results. Higher IgG levels and immunogenicity were found in the PE-Ch and NPE-Ch groups, whereas increased IgA levels were found only in the PE-Ch group post-vaccination. The PE-Co group showed a positive correlation between the IgA and IgG values, and lower IgG levels post-vaccination were associated with age. Significant alterations in the percentage of naive (CD28+CD57-), double-positive (CD28+CD57+), and senescent (CD28-CD57+) CD4+ T and CD8+ T cells were found post-vaccination, particularly in the PE-Ch group. Conclusions: The volunteers vaccinated with the ChadOx-1 presented not only a better antibody response but also a significant modulation in the percentage of T cell profiles, mainly in the previously exercised group.

Suggested Citation

  • Brenda Rodrigues Silva & Fernanda Rodrigues Monteiro & Kizzy Cezário & Jônatas Bussador do Amaral & Vitória Paixão & Ewin Barbosa Almeida & Carlos André Freitas dos Santos & Gislene Rocha Amirato & Da, 2023. "Older Adults Who Maintained a Regular Physical Exercise Routine before the Pandemic Show Better Immune Response to Vaccination for COVID-19," IJERPH, MDPI, vol. 20(3), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:20:y:2023:i:3:p:1939-:d:1042546
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    References listed on IDEAS

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