IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i3p1129-d488251.html
   My bibliography  Save this article

Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season

Author

Listed:
  • Ainara Mira-Iglesias

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain
    Equally contributed.)

  • F. Xavier López-Labrador

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain
    Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Equally contributed.)

  • Javier García-Rubio

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain)

  • Beatriz Mengual-Chuliá

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain)

  • Miguel Tortajada-Girbés

    (Hospital Universitario Doctor Peset, 46017 Valencia, Spain)

  • Joan Mollar-Maseres

    (Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain)

  • Mario Carballido-Fernández

    (Hospital General Universitario de Castellón, 12004 Castellón, Spain
    Departamento Medicina, Universidad CEU Cardenal Herrera, 12006 Castellón, Spain)

  • Germán Schwarz-Chavarri

    (Hospital General Universitario de Alicante, 03010 Alicante, Spain)

  • Joan Puig-Barberà

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain
    Centro de Salud Pública de Castellón, 12003 Castellón, Spain)

  • Javier Díez-Domingo

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain)

Abstract

Influenza vaccination is annually recommended for specific populations at risk, such as older adults. We estimated the 2018/2019 influenza vaccine effectiveness (IVE) overall, by influenza subtype, type of vaccine, and by time elapsed since vaccination among subjects 65 years old or over in a multicenter prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and other Respiratory Viruses (VAHNSI, Spain). Information about potential confounders was obtained from clinical registries and/or by interviewing patients and vaccination details were only ascertained by registries. A test-negative design was performed in order to estimate IVE. As a result, IVE was estimated at 46% (95% confidence interval (CI): (16%, 66%)), 41% (95% CI: (−34%, 74%)), and 45% (95% CI: (7%, 67%)) against overall influenza, A(H1N1)pdm09 and A(H3N2), respectively. An intra-seasonal not relevant waning effect was detected. The IVE for the adjuvanted vaccine in ≥75 years old was 45% (2%, 69%) and for the non-adjuvanted vaccine in 65–74 years old was 59% (−16%, 86%). Thus, our data revealed moderate vaccine effectiveness against influenza A(H3N2) and not significant against A(H1N1)pdm09. Significant protection was conferred by the adjuvanted vaccine to patients ≥75 years old. Moreover, an intra-seasonal not relevant waning effect was detected, and a not significant IVE decreasing trend was observed over time.

Suggested Citation

  • Ainara Mira-Iglesias & F. Xavier López-Labrador & Javier García-Rubio & Beatriz Mengual-Chuliá & Miguel Tortajada-Girbés & Joan Mollar-Maseres & Mario Carballido-Fernández & Germán Schwarz-Chavarri & , 2021. "Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season," IJERPH, MDPI, vol. 18(3), pages 1-19, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1129-:d:488251
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/3/1129/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/3/1129/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Greenland, S., 1989. "Modeling and variable selection in epidemiologic analysis," American Journal of Public Health, American Public Health Association, vol. 79(3), pages 340-349.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Heffner, Kathi L. & Waring, Molly E. & Roberts, Mary B. & Eaton, Charles B. & Gramling, Robert, 2011. "Social isolation, C-reactive protein, and coronary heart disease mortality among community-dwelling adults," Social Science & Medicine, Elsevier, vol. 72(9), pages 1482-1488, May.
    2. Scharoun-Lee, Melissa & Adair, Linda S. & Kaufman, Jay S. & Gordon-Larsen, Penny, 2009. "Obesity, race/ethnicity and the multiple dimensions of socioeconomic status during the transition to adulthood: A factor analysis approach," Social Science & Medicine, Elsevier, vol. 68(4), pages 708-716, February.
    3. Ching-Tang Kuo & Fen-Fen Chiu & Bo-Ying Bao & Ta-Yuan Chang, 2018. "Determination and Prediction of Respirable Dust and Crystalline-Free Silica in the Taiwanese Foundry Industry," IJERPH, MDPI, vol. 15(10), pages 1-15, September.
    4. Juhn, Young J. & Sauver, Jennifer St. & Katusic, Slavica & Vargas, Delfino & Weaver, Amy & Yunginger, John, 2005. "The influence of neighborhood environment on the incidence of childhood asthma: a multilevel approach," Social Science & Medicine, Elsevier, vol. 60(11), pages 2453-2464, June.
    5. Hasselle, Amanda J. & Napier, Taylor R. & Howell, Kathryn H., 2023. "Children’s self-perception: Investigating associations with direct victimization, indirect victimization, and caregiver partner violence," Children and Youth Services Review, Elsevier, vol. 144(C).
    6. Angela Marcia Cabral Mendonça & Afrânio Lineu Kritski & Marcelo Gerardin Poirot Land & Clemax Couto Sant’Anna, 2016. "Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil," PLOS ONE, Public Library of Science, vol. 11(5), pages 1-12, May.
    7. Matilda Annerstedt Van den Bosch & Per-Olof Östergren & Patrik Grahn & Erik Skärbäck & Peter Währborg, 2015. "Moving to Serene Nature May Prevent Poor Mental Health—Results from a Swedish Longitudinal Cohort Study," IJERPH, MDPI, vol. 12(7), pages 1-16, July.
    8. Edna M. Gamboa-Delgado & Doris C. Quintero-Lesmes & Oscar F. Herrán, 2018. "Alcohol Intake by Workers in a Health Care Institution in Bucaramanga, Colombia," Global Journal of Health Science, Canadian Center of Science and Education, vol. 10(11), pages 1-95, November.
    9. Zhu C & Blizzard L & Stankovich J & Wills K & Hosmer DW, 2018. "Be Wary of Using Poisson Regression to Estimate Risk and Relative Risk," Biostatistics and Biometrics Open Access Journal, Juniper Publishers Inc., vol. 4(5), pages 120-122, February.
    10. Diana Marina Camargo & Paula Camila Ramírez & Rogério César Fermino, 2017. "Individual and Environmental Correlates to Quality of Life in Park Users in Colombia," IJERPH, MDPI, vol. 14(10), pages 1-10, October.
    11. Raymond A. Tetteh & Edmund T. Nartey & Margaret Lartey & Aukje K. Mantel-Teeuwisse & Hubert G. M. Leufkens & Barbara A. Yankey & Alexander N. O. Dodoo, 2016. "Association Between the Occurrence of Adverse Drug Events and Modification of First-Line Highly Active Antiretroviral Therapy in Ghanaian HIV Patients," Drug Safety, Springer, vol. 39(11), pages 1139-1149, November.
    12. Ludwing Flórez-Salamanca & Edwin Herazo & Heidi Celina Oviedo & Adalberto Campo-Arias, 2014. "Prevalence and Predictors of High Sexual Prejudice Among Medical Students From Two Colombian Cities," SAGE Open, , vol. 4(2), pages 21582440145, June.
    13. Kuhnert, Petra M. & Do, Kim-Anh & McClure, Rod, 2000. "Combining non-parametric models with logistic regression: an application to motor vehicle injury data," Computational Statistics & Data Analysis, Elsevier, vol. 34(3), pages 371-386, September.
    14. Matthew Keeble & Jean Adams & Gary Sacks & Lana Vanderlee & Christine M. White & David Hammond & Thomas Burgoine, 2020. "Use of Online Food Delivery Services to Order Food Prepared Away-From-Home and Associated Sociodemographic Characteristics: A Cross-Sectional, Multi-Country Analysis," IJERPH, MDPI, vol. 17(14), pages 1-17, July.
    15. Laura Haas & Tom Stargardt & Jonas Schreyoegg, 2012. "Cost-effectiveness of open versus laparoscopic appendectomy: a multilevel approach with propensity score matching," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 13(5), pages 549-560, October.
    16. Ivone Duarte & Ana Alves & Ana Coelho & Ana Ferreira & Beatriz Cabral & Bebiana Silva & João Peralta & Juliana Silva & Pedro Domingues & Pedro Nunes & Carla Serrão & Cristina Santos, 2022. "The Mediating Role of Resilience and Life Satisfaction in the Relationship between Stress and Burnout in Medical Students during the COVID-19 Pandemic," IJERPH, MDPI, vol. 19(5), pages 1-13, February.
    17. Per I. Bank-Nielsen & Manhai Long & Eva C. Bonefeld-Jørgensen, 2019. "Pregnant Inuit Women’s Exposure to Metals and Association with Fetal Growth Outcomes: ACCEPT 2010–2015," IJERPH, MDPI, vol. 16(7), pages 1-27, April.
    18. Stella T Lartey & Costan G Magnussen & Lei Si & Barbara de Graaff & Richard Berko Biritwum & George Mensah & Alfred Yawson & Nadia Minicuci & Paul Kowal & Godfred O Boateng & Andrew J Palmer, 2019. "The role of intergenerational educational mobility and household wealth in adult obesity: Evidence from Wave 2 of the World Health Organization’s Study on global AGEing and adult health," PLOS ONE, Public Library of Science, vol. 14(1), pages 1-19, January.
    19. Akiko Kada & Zhihong Cai & Manabu Kuroki, 2013. "Medical diagnostic test based on the potential test result approach: bounds and identification," Journal of Applied Statistics, Taylor & Francis Journals, vol. 40(8), pages 1659-1672, August.
    20. Narmeen Mallah & Adolfo Figueiras & Bahi Takkouche, 2021. "Comparison of Longitudinal and Cross-Sectional Approaches in Studies About Knowledge, Attitude, and Practices Related to Antibiotic Misuse," Drug Safety, Springer, vol. 44(7), pages 797-809, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1129-:d:488251. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.