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U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women

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  • Yea-Chan Lee

    (Department of Family Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
    Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si 16995, Gyeonggi-do, Korea)

  • Da-Hye Son

    (Department of Family Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea)

  • Yu-Jin Kwon

    (Department of Family Medicine, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul 03722, Korea
    Department of Family Medicine, Yongin Severance Hospital, Yonsei University College of Medicine, 363, Dongbaekjukjeon-daero, Giheung-gu, Yongin-si 16995, Gyeonggi-do, Korea)

Abstract

Serum high-sensitivity C-reactive protein (hsCRP) and serum uric acid (SUA) are biomarkers that predict chronic inflammation and cardiovascular dysfunction. Therefore, we aimed to investigate the association between sleep duration, hsCRP, and SUA in Korean women. Cross-sectional data from the Seventh Korea National Health and Nutrition Examination Survey was analyzed. The odds ratio (OR) and 95% confidence intervals (CIs) for an association between higher hsCRP (>2.0 mg/L) or higher SUA (>5.6 mg/dL) and sleep duration were calculated using multiple logistic regression analyses after adjusting for potential confounders. In total, 6151 women were included in the analysis. There was a U-shaped relationship between continuous sleep duration, hsCRP, and SUA. Compared to those who slept for 7–8 h, the ORs (95% CIs) for higher hsCRP were 1.43 (0.95–2.16) in short sleepers and 1.64 (1.09–2.48) in long sleepers after adjusting for confounders. Compared with those who slept for 7–8 h, the ORs (95% CIs) for higher SUA were 1.54 (1.04–2.26) in short sleepers and 1.94 (1.27–2.96) in long sleepers after adjusting for confounders. We found a U-shaped association between sleep duration, hsCRP, and SUA in Korean women. 7–8 h sleep was associated with lower level of hsCRP and SUA in Korean women.

Suggested Citation

  • Yea-Chan Lee & Da-Hye Son & Yu-Jin Kwon, 2020. "U-Shaped Association between Sleep Duration, C-Reactive Protein, and Uric Acid in Korean Women," IJERPH, MDPI, vol. 17(8), pages 1-11, April.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:8:p:2657-:d:344814
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    References listed on IDEAS

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    1. Nancy J. Devlin & Richard Brooks, 2017. "EQ-5D and the EuroQol Group: Past, Present and Future," Applied Health Economics and Health Policy, Springer, vol. 15(2), pages 127-137, April.
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    1. Huan Yu & Kexiang Shi & Haiming Yang & Dianjianyi Sun & Jun Lv & Yuan Ma & Sailimai Man & Jianchun Yin & Bo Wang & Canqing Yu & Liming Li, 2022. "Association of Sleep Duration with Hyperuricemia in Chinese Adults: A Prospective Longitudinal Study," IJERPH, MDPI, vol. 19(13), pages 1-11, July.
    2. Karolina Kósa & Szilvia Vincze & Ilona Veres-Balajti & Éva Bácsné Bába, 2023. "The Pendulum Swings Both Ways: Evidence for U-Shaped Association between Sleep Duration and Mental Health Outcomes," IJERPH, MDPI, vol. 20(9), pages 1-13, April.

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