IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v15y2018i12p2701-d186566.html
   My bibliography  Save this article

The Role of Vitamin D and Oxidative Stress in Chronic Kidney Disease

Author

Listed:
  • Keith C. Norris

    (Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA)

  • Opeyemi Olabisi

    (Department of Medicine, Harvard Medical School, Harvard University, Boston, MA 02138, USA)

  • M. Edwina Barnett

    (RCMI Translational Research Network Data Coordinating Center, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA)

  • Yuan-Xiang Meng

    (Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA)

  • David Martins

    (Department of Medicine, College of Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA 90059, USA)

  • Chamberlain Obialo

    (Department of Family Medicine, Morehouse School of Medicine, Atlanta, GA 30310, USA)

  • Jae Eun Lee

    (RCMI Translational Research Network Data Coordinating Center, College of Science, Engineering and Technology, Jackson State University, Jackson, MS 39217, USA)

  • Susanne B. Nicholas

    (Department of Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90024, USA)

Abstract

Chronic kidney disease (CKD) is a major non-communicable disease associated with high rates of premature morbidity and mortality. The prevalence of hypovitaminosis D (deficiency of 25(OH)D or 25D) is greater in racial/ethnic minorities and in patients with CKD than the general population. Low 25D is associated with bone and mineral disorders as well as immune, cardiometabolic and cardiovascular (CV) diseases. Thus, it has been suggested that low 25D contributes to the poor outcomes in patients with CKD. The prevalence of hypovitaminosis D rises progressively with advancing severity of kidney disease with over 30% of patients with CKD stage 3 and 70% patients with CKD stage 5 estimated to have low levels of 25D. This report describes several of the abnormal physiologic and counter-regulatory actions related to low 25D in CKD such as those in oxidative stress and inflammatory systems, and some of the preclinical and clinical evidence, or lack thereof, of normalizing serum 25D levels to improve outcomes in patients with CKD, and especially for the high risk subset of racial/ethnic minorities who suffer from higher rates of advanced CKD and hypovitaminosis D.

Suggested Citation

  • Keith C. Norris & Opeyemi Olabisi & M. Edwina Barnett & Yuan-Xiang Meng & David Martins & Chamberlain Obialo & Jae Eun Lee & Susanne B. Nicholas, 2018. "The Role of Vitamin D and Oxidative Stress in Chronic Kidney Disease," IJERPH, MDPI, vol. 15(12), pages 1-7, November.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:12:p:2701-:d:186566
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/15/12/2701/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/15/12/2701/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Garland, C.F. & Garland, F.C. & Gorham, E.D. & Lipkin, M. & Newmark, H. & Mohr, S.B. & Holick, M.F., 2006. "The role of vitamin D in cancer prevention," American Journal of Public Health, American Public Health Association, vol. 96(2), pages 252-261.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Brian A. Chu & Vijaya Surampudi & Zhaoping Li & Christina Harris & Teresa Seeman & Keith C. Norris & Tara Vijayan, 2022. "Micronutrient Deficiency as a Confounder in Ascertaining the Role of Obesity in Severe COVID-19 Infection," IJERPH, MDPI, vol. 19(3), pages 1-13, January.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Daniel Aggio & Lee Smith & Abigail Fisher & Mark Hamer, 2015. "Association of Light Exposure on Physical Activity and Sedentary Time in Young People," IJERPH, MDPI, vol. 12(3), pages 1-9, March.
    2. Scott Carson, 2011. "Demographic, Residential, and Socioeconomic Effects on the Distribution of the Statures of Whites in the Nineteenth-Century U.S," Mathematical Population Studies, Taylor & Francis Journals, vol. 18(1), pages 1-17.
    3. Scott A. Carson, 2009. "Demographic, Residential, and Socioeconomic Effects on the Distribution of 19th Century US White Statures," CESifo Working Paper Series 2563, CESifo.
    4. Mário Santos & Helena Moreira & João Alexandre Cabral & Ronaldo Gabriel & Andreia Teixeira & Rita Bastos & Alfredo Aires, 2022. "Contribution of Home Gardens to Sustainable Development: Perspectives from A Supported Opinion Essay," IJERPH, MDPI, vol. 19(20), pages 1-26, October.
    5. Scott A. Carson, 2008. "Nineteenth Century Black and White US Statures: The Primary Sources of Vitamin D and their Relationship with Height," CESifo Working Paper Series 2497, CESifo.
    6. Adam Cook, 2022. "Saving lives: the 2006 expansion of daylight saving in Indiana," Journal of Population Economics, Springer;European Society for Population Economics, vol. 35(3), pages 861-891, July.
    7. Scott A. Carson, 2009. "The Relationship between Stature and Insolation: Evidence from Soldiers and Prisoners," CESifo Working Paper Series 2850, CESifo.
    8. Hui Zheng & Yang Yang & Kenneth Land, 2011. "Heterogeneity in the Strehler-Mildvan General Theory of Mortality and Aging," Demography, Springer;Population Association of America (PAA), vol. 48(1), pages 267-290, February.
    9. Carson, Scott Alan, 2011. "Was the 19th century stature-insolation relationship similar across independent samples? Evidence from soldiers and prisoners," Journal of Behavioral and Experimental Economics (formerly The Journal of Socio-Economics), Elsevier, vol. 40(2), pages 199-207, April.
    10. Scott A. Carson, 2008. "Demographic, Residential, and Socioeconomic Effects on the Distribution of 19th Century African-American Stature," CESifo Working Paper Series 2479, CESifo.
    11. Carson, Scott Alan, 2009. "Geography, insolation, and vitamin D in nineteenth century US African-American and white statures," Explorations in Economic History, Elsevier, vol. 46(1), pages 149-159, January.
    12. Yanling Liu & Chenglin Li & Peizhan Chen & Xiaoguang Li & Mian Li & He Guo & Jingquan Li & Ruiai Chu & Hui Wang, 2013. "Polymorphisms in the Vitamin D Receptor (VDR) and the Risk of Ovarian Cancer: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-8, June.
    13. Tsogtbaatar Byambaa & Craig Janes & Tim Takaro & Kitty Corbett, 2015. "Putting Health Impact Assessment into practice through the lenses of diffusion of innovations theory: a review," Environment, Development and Sustainability: A Multidisciplinary Approach to the Theory and Practice of Sustainable Development, Springer, vol. 17(1), pages 23-40, February.
    14. Andersen, Thomas Barnebeck & Dalgaard, Carl-Johan & Skovsgaard, Christian Volmar & Selaya, Pablo, 2016. "Historical Migration Flows and Global Health Differences," DaCHE discussion papers 2016:1, University of Southern Denmark, Dache - Danish Centre for Health Economics.
    15. Scott Carson, 2011. "Nineteenth century African-American and white US statures: the primary sources of vitamin D and their relationship with height," Journal of Bioeconomics, Springer, vol. 13(1), pages 1-15, April.
    16. Jaap C. Hanekamp & Aalt Bast, 2008. "Why RDAs and ULs Are Incompatible Standards in the U‐Shape Micronutrient Model: A Philosophically Orientated Analysis of Micronutrients' Standardizations," Risk Analysis, John Wiley & Sons, vol. 28(6), pages 1639-1652, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:15:y:2018:i:12:p:2701-:d:186566. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.