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Entropy generation and cell growth with comments for a thermodynamic anticancer approach

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  • Lucia, Umberto

Abstract

The chemical–physical analysis of the DNA have pointed out the connections between forces, thermodynamics and kinetics. The entropy generation approach has been suggested as a thermodynamic approach to evaluate the accessible states for cancer systems, in relation to their thermodynamic characteristic quantities. Cancer can be described as an open complex dynamic and self-organizing system. The stationary states of tumour systems are analyzed by a thermodynamic approach by using the entropy generation. The aim of this paper is to improve the thermodynamic approach to cell systems, based on the entropy generation. The results obtained consist of the theoretical analysis of the lifetimes of the processes which occur in cells and the numerical evaluation of the theoretical model proposed. Some considerations on the interactions between external fields and cell systems are developed. A possible new anticancer therapy based on the entropy generation is proposed.

Suggested Citation

  • Lucia, Umberto, 2014. "Entropy generation and cell growth with comments for a thermodynamic anticancer approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 406(C), pages 107-118.
    • Handle: RePEc:eee:phsmap:v:406:y:2014:i:c:p:107-118
    DOI: 10.1016/j.physa.2014.03.053
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    References listed on IDEAS

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    1. Lucia, Umberto, 2014. "Entropy generation: Minimum inside and maximum outside," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 396(C), pages 61-65.
    2. Lucia, Umberto, 2013. "Stationary open systems: A brief review on contemporary theories on irreversibility," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(5), pages 1051-1062.
    3. Lucia, Umberto, 2014. "Entropy generation approach to cell systems," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 406(C), pages 1-11.
    4. Lucia, Umberto, 2013. "Thermodynamic paths and stochastic order in open systems," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(18), pages 3912-3919.
    5. Hajmohammadi, M.R. & Eskandari, H. & Saffar-Avval, M. & Campo, A., 2013. "A new configuration of bend tubes for compound optimization of heat and fluid flow," Energy, Elsevier, vol. 62(C), pages 418-424.
    6. Lucia, Umberto, 2013. "Carnot efficiency: Why?," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(17), pages 3513-3517.
    7. Lucia, U. & Maino, G., 2002. "Thermodynamical analysis of the dynamics of tumor interaction with the host immune system," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 313(3), pages 569-577.
    8. Lucia, Umberto, 2012. "Irreversibility in biophysical and biochemical engineering," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(23), pages 5997-6007.
    9. Lucia, Umberto, 2013. "Thermodynamics and cancer stationary states," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(17), pages 3648-3653.
    10. Lucia, U., 2012. "Maximum or minimum entropy generation for open systems?," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 391(12), pages 3392-3398.
    11. Lucia, Umberto, 2014. "Entropy generation and the Fokker–Planck equation," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 393(C), pages 256-260.
    12. Lucia, Umberto, 2014. "Overview on fuel cells," Renewable and Sustainable Energy Reviews, Elsevier, vol. 30(C), pages 164-169.
    13. Lucia, Umberto & Sciubba, Enrico, 2013. "From Lotka to the entropy generation approach," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(17), pages 3634-3639.
    14. Lucia, Umberto, 2013. "Entropy and exergy in irreversible renewable energy systems," Renewable and Sustainable Energy Reviews, Elsevier, vol. 20(C), pages 559-564.
    15. Lucia, Umberto, 2014. "Transport processes in biological systems: Tumoral cells and human brain," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 393(C), pages 327-336.
    16. Lucia, Umberto, 2013. "Exergy flows as bases of constructal law," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 392(24), pages 6284-6287.
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    Cited by:

    1. Lucia, Umberto, 2014. "Thermodynamic approach to nano-properties of cell membrane," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 407(C), pages 185-191.
    2. Quijano, Juan C. & Lin, Henry, 2015. "Is spatially integrated entropy production useful to predict the dynamics of ecosystems?," Ecological Modelling, Elsevier, vol. 313(C), pages 341-354.
    3. Lucia, Umberto & Ponzetto, Antonio & Deisboeck, Thomas S., 2016. "Investigating the impact of electromagnetic fields on human cells: A thermodynamic perspective," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 443(C), pages 42-48.
    4. Betancourt-Mar, J.A. & Llanos-Pérez, J.A. & Cocho, G. & Mansilla, R. & Martin, R.R. & Montero, S. & Nieto-Villar, J.M., 2017. "Phase transitions in tumor growth: IV relationship between metabolic rate and fractal dimension of human tumor cells," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 473(C), pages 344-351.
    5. Lucia, Umberto, 2016. "Considerations on non equilibrium thermodynamics of interactions," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 447(C), pages 314-319.
    6. Lucia, Umberto & Ponzetto, Antonio & Deisboeck, Thomas S., 2015. "A thermodynamic approach to the ‘mitosis/apoptosis’ ratio in cancer," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 436(C), pages 246-255.
    7. Lucia, Umberto & Ponzetto, Antonio, 2017. "Some thermodynamic considerations on low frequency electromagnetic waves effects on cancer invasion and metastasis," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 467(C), pages 289-295.
    8. Llanos-Pérez, J.A. & Betancourt-Mar, A. & De Miguel, M.P. & Izquierdo-Kulich, E. & Royuela-García, M. & Tejera, E. & Nieto-Villar, J.M., 2015. "Phase transitions in tumor growth: II prostate cancer cell lines," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 426(C), pages 88-92.
    9. Umberto Lucia, 2014. "The Gouy-Stodola Theorem in Bioenergetic Analysis of Living Systems (Irreversibility in Bioenergetics of Living Systems)," Energies, MDPI, vol. 7(9), pages 1-23, September.

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