IDEAS home Printed from https://ideas.repec.org/a/eee/jbrese/v149y2022icp728-735.html
   My bibliography  Save this article

The emergence of entrepreneurial ecosystems based on enabling technologies: Evidence from synthetic biology

Author

Listed:
  • Nylund, Petra A.
  • Ferràs-Hernández, Xavier
  • Pareras, Luis
  • Brem, Alexander

Abstract

Certain technologies have the potential to spawn an entrepreneurial ecosystem, but this potential is not always realized. Some of these technologies that could enable prosperous and sustainable ecosystems struggle at the threshold of ecosystem emergence. In this paper, we use an in-depth case study of an emergent entrepreneurial ecosystem based on an enabling technology—synthetic biology—to identify the structural, societal, and ethical barriers to ecosystem growth. The structural barriers mainly relate to the lack of an ecosystem framework to manage intellectual property in complex interactions. The societal barriers concern the clock speed conflict between parts of the quintuple helix entrepreneurial ecosystem, and the ethical barriers arise from the widespread impact of enabling technologies in combination with the diffusion of ethical responsibility throughout the ecosystem. We also discuss both the theoretical and managerial implications of these barriers.

Suggested Citation

  • Nylund, Petra A. & Ferràs-Hernández, Xavier & Pareras, Luis & Brem, Alexander, 2022. "The emergence of entrepreneurial ecosystems based on enabling technologies: Evidence from synthetic biology," Journal of Business Research, Elsevier, vol. 149(C), pages 728-735.
  • Handle: RePEc:eee:jbrese:v:149:y:2022:i:c:p:728-735
    DOI: 10.1016/j.jbusres.2022.05.071
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0148296322005100
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.jbusres.2022.05.071?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Scott L. Greer & Benjamin Trump, 2019. "Regulation and regime: the comparative politics of adaptive regulation in synthetic biology," Policy Sciences, Springer;Society of Policy Sciences, vol. 52(4), pages 505-524, December.
    2. Roundy, Philip T. & Bradshaw, Mike & Brockman, Beverly K., 2018. "The emergence of entrepreneurial ecosystems: A complex adaptive systems approach," Journal of Business Research, Elsevier, vol. 86(C), pages 1-10.
    3. Ratten, Vanessa & da Silva Braga, Vitor Lélio & da Encarnação Marques, Carla Susana, 2021. "Sport entrepreneurship and value co-creation in times of crisis: The covid-19 pandemic," Journal of Business Research, Elsevier, vol. 133(C), pages 265-274.
    4. Ron Adner & Rahul Kapoor, 2016. "Innovation ecosystems and the pace of substitution: Re-examining technology S-curves," Strategic Management Journal, Wiley Blackwell, vol. 37(4), pages 625-648, April.
    5. Brem, Alexander & Nylund, Petra & Viardot, Eric, 2020. "The impact of the 2008 financial crisis on innovation: A dominant design perspective," Journal of Business Research, Elsevier, vol. 110(C), pages 360-369.
    6. Teece, David J., 2018. "Profiting from innovation in the digital economy: Enabling technologies, standards, and licensing models in the wireless world," Research Policy, Elsevier, vol. 47(8), pages 1367-1387.
    7. F.C. Stam & Andrew van de Ven, 2018. "Entrepreneurial Ecosystems: A Systems Perspective," Working Papers 18-06, Utrecht School of Economics.
    8. Autio, Erkko & Kenney, Martin & Mustar, Philippe & Siegel, Don & Wright, Mike, 2014. "Entrepreneurial innovation: The importance of context," Research Policy, Elsevier, vol. 43(7), pages 1097-1108.
    9. Lori DiVito & Zita Ingen-Housz, 2021. "From individual sustainability orientations to collective sustainability innovation and sustainable entrepreneurial ecosystems," Small Business Economics, Springer, vol. 56(3), pages 1057-1072, February.
    10. Müller, Matthias & Kudic, Muhamed & Vermeulen, Ben, 2021. "The influence of the structure of technological knowledge on inter-firm R&D collaboration and knowledge discovery: An agent-based simulation approach," Journal of Business Research, Elsevier, vol. 129(C), pages 570-579.
    11. Mansell, Robin, 2021. "Adjusting to the digital: Societal outcomes and consequences," Research Policy, Elsevier, vol. 50(9).
    12. Allen, Darcy W.E. & Berg, Chris & Markey-Towler, Brendan & Novak, Mikayla & Potts, Jason, 2020. "Blockchain and the evolution of institutional technologies: Implications for innovation policy," Research Policy, Elsevier, vol. 49(1).
    13. David Urbano & Maribel Guerrero & João J. Ferreira & Cristina I. Fernandes, 2019. "New technology entrepreneurship initiatives: Which strategic orientations and environmental conditions matter in the new socio-economic landscape?," The Journal of Technology Transfer, Springer, vol. 44(5), pages 1577-1602, October.
    14. Ricarda B. Bouncken & Sascha Kraus, 2022. "Entrepreneurial ecosystems in an interconnected world: emergence, governance and digitalization," Review of Managerial Science, Springer, vol. 16(1), pages 1-14, January.
    15. Alfonso Gambardella & Sohvi Heaton & Elena Novelli & David J. Teece, 2021. "Profiting from Enabling Technologies?," Strategy Science, INFORMS, vol. 6(1), pages 75-90, March.
    16. Ferràs-Hernández, Xavier & Tarrats-Pons, Elisenda & Arimany-Serrat, Núria, 2017. "Disruption in the automotive industry: A Cambrian moment," Business Horizons, Elsevier, vol. 60(6), pages 855-863.
    17. Roberta Kwok, 2010. "Five hard truths for synthetic biology," Nature, Nature, vol. 463(7279), pages 288-290, January.
    18. Brem, Alexander & Viardot, Eric & Nylund, Petra A., 2021. "Implications of the coronavirus (COVID-19) outbreak for innovation: Which technologies will improve our lives?," Technological Forecasting and Social Change, Elsevier, vol. 163(C).
    19. Fankang Meng & Tom Ellis, 2020. "The second decade of synthetic biology: 2010–2020," Nature Communications, Nature, vol. 11(1), pages 1-4, December.
    20. Benjamin Trump & Christopher Cummings & Jennifer Kuzma & Igor Linkov, 2018. "A decision analytic model to guide early‐stage government regulatory action: Applications for synthetic biology," Regulation & Governance, John Wiley & Sons, vol. 12(1), pages 88-100, March.
    21. Brice Dattée & Oliver Alexy & Erkko Autio, 2018. "Maneuvering in Poor Visibility : How Firms Play the Ecosystem Game when Uncertainty is High," Post-Print hal-02276702, HAL.
    22. Allan O'Connor & Erik Stam & Fiona Sussan & David B. Audretsch (ed.), 2018. "Entrepreneurial Ecosystems," International Studies in Entrepreneurship, Springer, number 978-3-319-63531-6, December.
    23. Jennifer Kuzma & Todd Tanji, 2010. "Unpackaging synthetic biology: Identification of oversight policy problems and options," Regulation & Governance, John Wiley & Sons, vol. 4(1), pages 92-112, March.
    24. Battisti, Sandro & Agarwal, Nivedita & Brem, Alexander, 2022. "Creating new tech entrepreneurs with digital platforms: Meta-organizations for shared value in data-driven retail ecosystems," Technological Forecasting and Social Change, Elsevier, vol. 175(C).
    25. Ufuah, Allan N & Utterback, James M, 1997. "Responding to Structural Industry Changes: A Technological Evolution Perspective," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 6(1), pages 183-202.
    26. Uwe Cantner & James A. Cunningham & Erik E. Lehmann & Matthias Menter, 2021. "Entrepreneurial ecosystems: a dynamic lifecycle model," Small Business Economics, Springer, vol. 57(1), pages 407-423, June.
    27. Allan O’Connor & Erik Stam & Fiona Sussan & David B. Audretsch, 2018. "Entrepreneurial Ecosystems: The Foundations of Place-based Renewal," International Studies in Entrepreneurship, in: Allan O'Connor & Erik Stam & Fiona Sussan & David B. Audretsch (ed.), Entrepreneurial Ecosystems, pages 1-21, Springer.
    28. Drew Endy, 2005. "Foundations for engineering biology," Nature, Nature, vol. 438(7067), pages 449-453, November.
    29. Markard, Jochen & Truffer, Bernhard, 2008. "Technological innovation systems and the multi-level perspective: Towards an integrated framework," Research Policy, Elsevier, vol. 37(4), pages 596-615, May.
    30. Masucci, Monica & Brusoni, Stefano & Cennamo, Carmelo, 2020. "Removing bottlenecks in business ecosystems: The strategic role of outbound open innovation," Research Policy, Elsevier, vol. 49(1).
    31. Michael G. Jacobides & Carmelo Cennamo & Annabelle Gawer, 2018. "Towards a theory of ecosystems," Strategic Management Journal, Wiley Blackwell, vol. 39(8), pages 2255-2276, August.
    32. Brice Dattée & Oliver Alexy & Erkko Autio, 2018. "Maneuvering in Poor Visibility : How Firms Play the Ecosystem Game when Uncertainty is High," Post-Print hal-02312003, HAL.
    33. Rachel Armstrong & Neil Spiller, 2010. "Synthetic biology: Living quarters," Nature, Nature, vol. 467(7318), pages 916-918, October.
    34. González-Serrano, María Huertas & Crespo-Hervás, Josep & Pérez-Campos, Carlos & Calabuig, Ferran, 2021. "Entrepreneurial ecosystems for developing the sports industry in European Union countries," Journal of Business Research, Elsevier, vol. 136(C), pages 667-677.
    35. Margherita, Emanuele Gabriel & Braccini, Alessio Maria, 2021. "Managing industry 4.0 automation for fair ethical business development: A single case study," Technological Forecasting and Social Change, Elsevier, vol. 172(C).
    36. David B. Audretsch & James A. Cunningham & Donald F. Kuratko & Erik E. Lehmann & Matthias Menter, 2019. "Entrepreneurial ecosystems: economic, technological, and societal impacts," The Journal of Technology Transfer, Springer, vol. 44(2), pages 313-325, April.
    37. Phillips, Mark A. & Ritala, Paavo, 2019. "A complex adaptive systems agenda for ecosystem research methodology," Technological Forecasting and Social Change, Elsevier, vol. 148(C).
    38. Geels, Frank W. & Kemp, René, 2007. "Dynamics in socio-technical systems: Typology of change processes and contrasting case studies," Technology in Society, Elsevier, vol. 29(4), pages 441-455.
    39. Ribeiro, Barbara & Shapira, Philip, 2020. "Private and public values of innovation: A patent analysis of synthetic biology," Research Policy, Elsevier, vol. 49(1).
    40. Bertello, Alberto & Battisti, Enrico & De Bernardi, Paola & Bresciani, Stefano, 2022. "An integrative framework of knowledge-intensive and sustainable entrepreneurship in entrepreneurial ecosystems," Journal of Business Research, Elsevier, vol. 142(C), pages 683-693.
    41. Petra A. Nylund & Boyd Cohen, 2017. "Collision density: driving growth in urban entrepreneurial ecosystems," International Entrepreneurship and Management Journal, Springer, vol. 13(3), pages 757-776, September.
    42. Xie, Zhimin & Wang, Xia & Xie, Lingmin & Duan, Kaifeng, 2021. "Entrepreneurial ecosystem and the quality and quantity of regional entrepreneurship: A configurational approach," Journal of Business Research, Elsevier, vol. 128(C), pages 499-509.
    43. Brem, Alexander & Radziwon, Agnieszka, 2017. "Efficient Triple Helix collaboration fostering local niche innovation projects – A case from Denmark," Technological Forecasting and Social Change, Elsevier, vol. 123(C), pages 130-141.
    44. Mansell, Robin, 2021. "Adjusting to the digital: societal outcomes and consequences," LSE Research Online Documents on Economics 111571, London School of Economics and Political Science, LSE Library.
    45. Han, Jin & Ruan, Yi & Wang, Yanmin & Zhou, Haibo, 2021. "Toward a complex adaptive system: The case of the Zhongguancun entrepreneurship ecosystem," Journal of Business Research, Elsevier, vol. 128(C), pages 537-550.
    46. Erik Stam, 2018. "Measuring Entrepreneurial Ecosystems," International Studies in Entrepreneurship, in: Allan O'Connor & Erik Stam & Fiona Sussan & David B. Audretsch (ed.), Entrepreneurial Ecosystems, pages 173-197, Springer.
    47. Walrave, Bob & Talmar, Madis & Podoynitsyna, Ksenia S. & Romme, A. Georges L. & Verbong, Geert P.J., 2018. "A multi-level perspective on innovation ecosystems for path-breaking innovation," Technological Forecasting and Social Change, Elsevier, vol. 136(C), pages 103-113.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mohammad Daradkeh, 2023. "Navigating the Complexity of Entrepreneurial Ethics: A Systematic Review and Future Research Agenda," Sustainability, MDPI, vol. 15(14), pages 1-30, July.
    2. Nylund, Petra A. & Amores-Bravo, Xavier & Ferràs-Hernández, Xavier & Brem, Alexander, 2023. "Crisis as a catalyst of idle innovation ecosystems: Evidence from ecosystem exaptation of a water partnership," Technological Forecasting and Social Change, Elsevier, vol. 197(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Gomes, Leonardo Augusto de Vasconcelos & Flechas, Ximena Alejandra & Facin, Ana Lucia Figueiredo & Borini, Felipe Mendes, 2021. "Ecosystem management: Past achievements and future promises," Technological Forecasting and Social Change, Elsevier, vol. 171(C).
    2. Bessagnet, Arnauld & Crespo, Joan & Vicente, Jérôme, 2021. "Unraveling the multi-scalar and evolutionary forces of entrepreneurial ecosystems: A historical event analysis applied to IoT Valley," Technovation, Elsevier, vol. 108(C).
    3. Shi, Xianwei & Liang, Xingkun & Luo, Yining, 2023. "Unpacking the intellectual structure of ecosystem research in innovation studies," Research Policy, Elsevier, vol. 52(6).
    4. Bejjani, Melissa & Göcke, Lutz & Menter, Matthias, 2023. "Digital entrepreneurial ecosystems: A systematic literature review," Technological Forecasting and Social Change, Elsevier, vol. 189(C).
    5. Abootorabi, Hooman & Wiklund, Johan & Johnson, Alan R. & Miller, Cameron D., 2021. "A holistic approach to the evolution of an entrepreneurial ecosystem: An exploratory study of academic spin-offs," Journal of Business Venturing, Elsevier, vol. 36(5).
    6. Leendertse, Jip & Schrijvers, Mirella & Stam, Erik, 2022. "Measure Twice, Cut Once: Entrepreneurial Ecosystem Metrics," Research Policy, Elsevier, vol. 51(9).
    7. Manel Arribas-Ibar & Petra A. Nylund & Alexander Brem, 2021. "The Risk of Dissolution of Sustainable Innovation Ecosystems in Times of Crisis: The Electric Vehicle during the COVID-19 Pandemic," Sustainability, MDPI, vol. 13(3), pages 1-14, January.
    8. Han, Jin & Zhou, Haibo & Löwik, Sandor & de Weerd-Nederhof, Petra, 2022. "Building and sustaining emerging ecosystems through new focal ventures: Evidence from China's bike-sharing industry," Technological Forecasting and Social Change, Elsevier, vol. 174(C).
    9. Maksim Belitski & Ana-Maria Grigore & Anca Bratu, 2021. "Political entrepreneurship: entrepreneurship ecosystem perspective," International Entrepreneurship and Management Journal, Springer, vol. 17(4), pages 1973-2004, December.
    10. Quoc Hoang Thai & Khuong Ngoc Mai & Tung Thanh Do, 2023. "An Evolution of Entrepreneurial Ecosystem Studies: A Systematic Literature Review and Future Research Agenda," SAGE Open, , vol. 13(1), pages 21582440231, March.
    11. Hou, Hong & Shi, Yongjiang, 2021. "Ecosystem-as-structure and ecosystem-as-coevolution: A constructive examination," Technovation, Elsevier, vol. 100(C).
    12. Jarryd Daymond & Eric Knight & Maria Rumyantseva & Steven Maguire, 2023. "Managing ecosystem emergence and evolution: Strategies for ecosystem architects," Strategic Management Journal, Wiley Blackwell, vol. 44(4), pages 1-27, April.
    13. Nylund, Petra A. & Amores-Bravo, Xavier & Ferràs-Hernández, Xavier & Brem, Alexander, 2023. "Crisis as a catalyst of idle innovation ecosystems: Evidence from ecosystem exaptation of a water partnership," Technological Forecasting and Social Change, Elsevier, vol. 197(C).
    14. Daniel Sunghwan Cho & Paul Ryan & Giulio Buciuni, 2022. "Evolutionary entrepreneurial ecosystems: a research pathway," Small Business Economics, Springer, vol. 58(4), pages 1865-1883, April.
    15. Coad, Alex & Srhoj, Stjepan, 2023. "Entrepreneurial ecosystems and regional persistence of high growth firms: A ‘broken clock’ critique," Research Policy, Elsevier, vol. 52(6).
    16. Yanzhang Gu & Longying Hu & Hongjin Zhang & Chenxuan Hou, 2021. "Innovation Ecosystem Research: Emerging Trends and Future Research," Sustainability, MDPI, vol. 13(20), pages 1-21, October.
    17. Okpalaoka, Chijindu Iheanacho, 2023. "Research on the digital economy: Developing trends and future directions," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    18. Theodoraki, Christina & Dana, Léo-Paul & Caputo, Andrea, 2022. "Building sustainable entrepreneurial ecosystems: A holistic approach," Journal of Business Research, Elsevier, vol. 140(C), pages 346-360.
    19. Granstrand, Ove & Holgersson, Marcus, 2020. "Innovation ecosystems: A conceptual review and a new definition," Technovation, Elsevier, vol. 90.
    20. Dedehayir, Ozgur & Mäkinen, Saku J. & Ortt, J. Roland, 2022. "Innovation ecosystems as structures: Actor roles, timing of their entrance, and interactions," Technological Forecasting and Social Change, Elsevier, vol. 183(C).

    More about this item

    Keywords

    Entrepreneurial ecosystems; Ecosystem emergence; Complex adaptive systems; Enabling technologies; Synthetic biology;
    All these keywords.

    JEL classification:

    • L26 - Industrial Organization - - Firm Objectives, Organization, and Behavior - - - Entrepreneurship
    • M13 - Business Administration and Business Economics; Marketing; Accounting; Personnel Economics - - Business Administration - - - New Firms; Startups
    • O32 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Management of Technological Innovation and R&D
    • O34 - Economic Development, Innovation, Technological Change, and Growth - - Innovation; Research and Development; Technological Change; Intellectual Property Rights - - - Intellectual Property and Intellectual Capital

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:jbrese:v:149:y:2022:i:c:p:728-735. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.elsevier.com/locate/jbusres .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.