IDEAS home Printed from https://ideas.repec.org/a/adm/journl/v10y2021i2p13-21.html
   My bibliography  Save this article

Novel Butan-2-ylidene Benzohydrazides; Synthesis, Antimicrobial Evaluation and Molecular Docking Study

Author

Listed:
  • Ezeokonkwo Mercy A.
  • Onwosi Ekene L.
  • Odimegwu Damian C.
  • Okafor Sunday N.
  • Eze Cosmas C.
  • Amaechi Dominic C.
  • Attah Solomon I.
  • Okpareke Obinna C.

Abstract

A variety of butan-2-ylidene benzohydrazides were synthesized via the reaction of benzohydrazides with 4,4,4-triflouro-1-phenyl-1,-3-butanedione/4,4,4 – triflouro -1, 2, - (2 – napthyl) -1, 3 – butanedione. Acetylation and benzoylation of butan-2-ylidene benzohydrazides gave the derivatives previously unknown. The compounds were characterized by spectral analyses (Mass spec., IR, and NMR), and were evaluated for their in vitro antimicrobial activity against some clinical isolates of interest. The in vitro screening revealed that some of the compounds possessed strong inhibitory potentials against the isolates with IZD in the range of 7-14 mm. Predicted ADMET ensured the druggability properties of the synthesized compounds. The molecular docking study indicated compounds7a and 9a to possess the highest docking store and established significant interactions in the active site of the target protein.

Suggested Citation

  • Ezeokonkwo Mercy A. & Onwosi Ekene L. & Odimegwu Damian C. & Okafor Sunday N. & Eze Cosmas C. & Amaechi Dominic C. & Attah Solomon I. & Okpareke Obinna C., 2021. "Novel Butan-2-ylidene Benzohydrazides; Synthesis, Antimicrobial Evaluation and Molecular Docking Study," International Journal of Sciences, Office ijSciences, vol. 10(02), pages 13-21, February.
    • Handle: RePEc:adm:journl:v:10:y:2021:i:2:p:13-21
    DOI: 10.18483/ijSci.2420
    as

    Download full text from publisher

    File URL: https://www.ijsciences.com/pub/article/2420
    Download Restriction: no
    File URL: https://www.ijsciences.com/pub/pdf/V102021022420.pdf
    Download Restriction: no
    File URL: https://libkey.io/10.18483/ijSci.2420?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Tsang, Eric W. K., 2014. "Old and New," Management and Organization Review, Cambridge University Press, vol. 10(03), pages 390-390, November.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Ali Shalizar Jalali, 2018. "Male Fertility as a Bull’s Eye for Mastocytosis," Global Journal of Reproductive Medicine, Juniper Publishers Inc., vol. 3(3), pages 58-60, February.
    2. O'Connor, Genevieve E. & Myrden, Susan & Alkire (née Nasr), Linda & Lee, Kyungwon & Köcher, Sören & Kandampully, Jay & Williams, Jerome D., 2021. "Digital Health Experience: A Regulatory Focus Perspective," Journal of Interactive Marketing, Elsevier, vol. 56(C), pages 121-136.
    3. Tong Fu & Hongzhang Chen & Yongrok Choi, 2016. "Does the Sustainable PPI Investments Promote Financial Market’s Sustainable Development?," Sustainability, MDPI, vol. 8(2), pages 1-18, January.
    4. Lizin, Sebastien & Van Dael, Miet & Van Passel, Steven, 2017. "Battery pack recycling: Behaviour change interventions derived from an integrative theory of planned behaviour study," Resources, Conservation & Recycling, Elsevier, vol. 122(C), pages 66-82.
    5. Bobby Macaulay, 2016. "Considering social enterprise involvement in the commissioning of health services in Shetland," Local Economy, London South Bank University, vol. 31(5), pages 650-659, August.
    6. Rujirutana Mandhachitara & Randall Shannon, 2016. "The Formation and Sustainability of same Product Retail Store Clusters in A Modern Mega City," Tijdschrift voor Economische en Sociale Geografie, Royal Dutch Geographical Society KNAG, vol. 107(5), pages 567-581, December.
    7. Krolikowski, Pawel M. & McCallum, Andrew H., 2021. "Goods-market frictions and international trade," Journal of International Economics, Elsevier, vol. 129(C).
    8. Daniela ANTONESCU & Florina POPA, 2016. "Criteria of Economic and Social Efficiency of Public Administration in Romania," Romanian Journal of Economics, Institute of National Economy, vol. 43(2(52)), pages 156-184, december.
    9. Gabriel RAITA & Teodora Odett BREAZ, 2021. "The Era Of Digitalization And Future Changes In The Accounting Profession," European Journal of Accounting, Finance & Business, "Stefan cel Mare" University of Suceava, Romania - Faculty of Economics and Public Administration, West University of Timisoara, Romania - Faculty of Economics and Business Administration, vol. 16(26), pages 63-72, June.
    10. Evan Capeluck, 2014. "Convergence Across Provincial Economies in Canada: Trends, Drivers, and Implications," CSLS Research Reports 2014-03, Centre for the Study of Living Standards.
    11. Rachel Margolis & Laura Wright, 2017. "Older Adults With Three Generations of Kin: Prevalence, Correlates, and Transfers," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 72(6), pages 1067-1072.
    12. Patrice Loisel & Marielle Brunette & Stéphane Couture, 2020. "Insurance and Forest Rotation Decisions Under Storm Risk," Environmental & Resource Economics, Springer;European Association of Environmental and Resource Economists, vol. 76(2), pages 347-367, July.
    13. Andrés Rodríguez-Pose & Callum Wilkie, 2015. "Institutions and the Entrepreneurial Discovery Process for Smart Specialization," Papers in Evolutionary Economic Geography (PEEG) 1523, Utrecht University, Department of Human Geography and Spatial Planning, Group Economic Geography, revised Jul 2015.
    14. Ali, Akbar & Raza, Zahid & Bhatti, Akhlaq Ahmad, 2016. "Bond incident degree (BID) indices of polyomino chains: A unified approach," Applied Mathematics and Computation, Elsevier, vol. 287, pages 28-37.
    15. Lees, Nic J. & Nuthall, P.L. & Wilson, M.M.J., 2016. "The impact of relationship quality on supplier performance in New Zealand agri-food supply chains," 26th International Food and Agribusiness Management Association (IFAMA) World Forum, 2016, Aarhus, Denmark 273035, International Food and Agribusiness Management Association (IFAMA).
    16. Joan Calzada & Begoña García-Mariñoso & Jordi Ribé & Rafael Rubio & David Suárez, 2018. "Fiber deployment in Spain," Journal of Regulatory Economics, Springer, vol. 53(3), pages 256-274, June.
    17. Guido Busca, 2021. "Production of Gasolines and Monocyclic Aromatic Hydrocarbons: From Fossil Raw Materials to Green Processes," Energies, MDPI, vol. 14(13), pages 1-32, July.
    18. Hui Yan & Guixiang Liu, 2021. "Fire’s Effects on Grassland Restoration and Biodiversity Conservation," Sustainability, MDPI, vol. 13(21), pages 1-15, October.
    19. Jose Pina-Sánchez & John Paul Gosling, 2020. "Tackling selection bias in sentencing data analysis: a new approach based on a scale of severity," Quality & Quantity: International Journal of Methodology, Springer, vol. 54(3), pages 1047-1073, June.
    20. Tasaddaq Hussain & Muhammad Aslam Pervez & Syed Inamur Rahman, 2019. "Freedom of Expression versus Blasphemy: A Comparative Study of Pakistan and United States9apos9 News Media," Global Regional Review, Humanity Only, vol. 4(4), pages 130-139, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:adm:journl:v:10:y:2021:i:2:p:13-21. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Staff ijSciences (email available below). General contact details of provider: .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.