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Genetical and statistical aspects of polymerase chain reactions

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  • Brunnert, Marcus
  • Müller, Oliver
  • Urfer, Wolfgang

Abstract

In this paper we describe the principles of polymerase chain reaction (PCR) and its expanding use in molecular genetic research and molecular medicine. A short introduction of exemplary applications of the PCR is connected with a discussion of the lack of PCR accuracy. We give a statistical model for the PCR and discuss estimation methods in order to quantify the lack of PCR accuracy.

Suggested Citation

  • Brunnert, Marcus & Müller, Oliver & Urfer, Wolfgang, 2000. "Genetical and statistical aspects of polymerase chain reactions," Technical Reports 2000,06, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.
    • Handle: RePEc:zbw:sfb475:200006
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    File URL: https://www.econstor.eu/bitstream/10419/77228/2/2000-06.pdf
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    References listed on IDEAS

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    1. Selinski, Silvia, 2000. "Estimation of toxicokinetic population parameters in a four-stage hierarchical model," Technical Reports 2000,01, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.
    2. Urfer, Wolfgang & Mejza, S. & Hering, F., 1999. "Quantitative trait loci mapping in plant genetics by [alpha]-design experiments and molecular genetic marker systems," Technical Reports 1999,34, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.
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    Cited by:

    1. Guimaraes, Gabriela & Urfer, Wolfgang, 2000. "Self-organizing maps and its applications in sleep apnea research and molecular genetics," Technical Reports 2000,23, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.

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