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Copula-based modelling of self-reported health states: an application to the use of EQ-5D-3L and EQ-5D-5L in evaluating drug therapies for rheumatic disease

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  • Pudney, Stephen
  • Hernandez-Alava, Monica

Abstract

EQ-5D is used in cost-effectiveness studies underlying many important health policy decisions. It comprises a survey instrument generating a description of health states across five domains, and a system of utility values for each state. The original 3-level version of EQ-5D is being replaced with a more sensitive 5-level version but little is known about the consequences of this change. We develop a multi-equation ordinal response model incorporating a copula specification with normal mixture marginals to analyse the joint responses to EQ-5D-3L and EQ-5D-5L in a survey of people affected by rheumatoid disease, and use it to generate mappings between the 3-level and 5-level descriptive systems. We find significant conflicts between the two, which would imply the reversal of an important conclusion in a real-world evaluation of drug therapies.

Suggested Citation

  • Pudney, Stephen & Hernandez-Alava, Monica, 2016. "Copula-based modelling of self-reported health states: an application to the use of EQ-5D-3L and EQ-5D-5L in evaluating drug therapies for rheumatic disease," ISER Working Paper Series 2016-04, Institute for Social and Economic Research.
    • Handle: RePEc:ese:iserwp:2016-04
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    1. John Brazier & Yaling Yang & Aki Tsuchiya & Donna Rowen, 2010. "A review of studies mapping (or cross walking) non-preference based measures of health to generic preference-based measures," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 11(2), pages 215-225, April.
    2. Anastasios Panagiotelis & Claudia Czado & Harry Joe, 2012. "Pair Copula Constructions for Multivariate Discrete Data," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 107(499), pages 1063-1072, September.
    3. Oliver Rivero-Arias & Melissa Ouellet & Alastair Gray & Jane Wolstenholme & Peter M. Rothwell & Ramon Luengo-Fernandez, 2010. "Mapping the Modified Rankin Scale (mRS) Measurement into the Generic EuroQol (EQ-5D) Health Outcome," Medical Decision Making, , vol. 30(3), pages 341-354, May.
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    1. Yang Li & Fan Wang & Ye Shen & Yichen Qin & Jiesheng Si, 2022. "Selection of mixed copula for association modeling with tied observations," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 31(5), pages 1127-1180, December.

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