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Benzene Risk Estimation Using Radiation Equivalent Coefficients

Author

Listed:
  • Aki Nakayama
  • Tomomi Isono
  • Takuro Kikuchi
  • Iichiro Ohnishi
  • Junichiro Igarashi
  • Minoru Yoneda
  • Shinsuke Morisawa

Abstract

We estimated benzene risk using a novel framework of risk assessment that employed the measurement of radiation dose equivalents to benzene metabolites and a PBPK model. The highest risks for 1 μg/m3 and 3.2 mg/m3 life time exposure of benzene estimated with a linear regression were 5.4 × 10−7 and 1.3 × 10−3, respectively. Even though these estimates were based on in vitro chromosome aberration test data, they were about one‐sixth to one‐fourteenth that from other studies and represent a fairly good estimate by using radiation equivalent coefficient as an “internal standard.”

Suggested Citation

  • Aki Nakayama & Tomomi Isono & Takuro Kikuchi & Iichiro Ohnishi & Junichiro Igarashi & Minoru Yoneda & Shinsuke Morisawa, 2009. "Benzene Risk Estimation Using Radiation Equivalent Coefficients," Risk Analysis, John Wiley & Sons, vol. 29(3), pages 380-392, March.
    • Handle: RePEc:wly:riskan:v:29:y:2009:i:3:p:380-392
    DOI: 10.1111/j.1539-6924.2008.01174.x
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    References listed on IDEAS

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    1. Karen H. Watanabe & Frédéric Y. Bois, 1996. "Interspecies Extrapolation of Physiological Pharmacokinetic Parameter Distributions," Risk Analysis, John Wiley & Sons, vol. 16(6), pages 741-754, December.
    2. Peter E. Voytek & Todd W. Thorslund, 1991. "Benzene Risk Assessment: Status of Quantifying the Leukemogenic Risk Associated with the Low‐Dose Inhalation of Benzene," Risk Analysis, John Wiley & Sons, vol. 11(3), pages 355-357, September.
    3. Elizabeth A. Brown & Michael L. Shelley & Jeffrey W. Fisher, 1998. "A Pharmacokinetic Study of Occupational and Environmental Benzene Exposure with Regard to Gender," Risk Analysis, John Wiley & Sons, vol. 18(2), pages 205-213, April.
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