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Blood Flow Velocity Field Estimation Via Spatial Regression With PDE Penalization

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  • Laura Azzimonti
  • Laura M. Sangalli
  • Piercesare Secchi
  • Maurizio Domanin
  • Fabio Nobile

Abstract

We propose an innovative method for the accurate estimation of surfaces and spatial fields when prior knowledge of the phenomenon under study is available. The prior knowledge included in the model derives from physics, physiology, or mechanics of the problem at hand, and is formalized in terms of a partial differential equation governing the phenomenon behavior, as well as conditions that the phenomenon has to satisfy at the boundary of the problem domain. The proposed models exploit advanced scientific computing techniques and specifically make use of the finite element method. The estimators have a penalized regression form and the usual inferential tools are derived. Both the pointwise and the areal data frameworks are considered. The driving application concerns the estimation of the blood flow velocity field in a section of a carotid artery, using data provided by echo-color Doppler. This applied problem arises within a research project that aims at studying atherosclerosis pathogenesis. Supplementary materials for this article are available online.

Suggested Citation

  • Laura Azzimonti & Laura M. Sangalli & Piercesare Secchi & Maurizio Domanin & Fabio Nobile, 2015. "Blood Flow Velocity Field Estimation Via Spatial Regression With PDE Penalization," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 110(511), pages 1057-1071, September.
    • Handle: RePEc:taf:jnlasa:v:110:y:2015:i:511:p:1057-1071
    DOI: 10.1080/01621459.2014.946036
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    References listed on IDEAS

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    1. Xiaolei Xun & Jiguo Cao & Bani Mallick & Arnab Maity & Raymond J. Carroll, 2013. "Parameter Estimation of Partial Differential Equation Models," Journal of the American Statistical Association, Taylor & Francis Journals, vol. 108(503), pages 1009-1020, September.
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    4. Finn Lindgren & Håvard Rue & Johan Lindström, 2011. "An explicit link between Gaussian fields and Gaussian Markov random fields: the stochastic partial differential equation approach," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 73(4), pages 423-498, September.
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    1. Eleonora Arnone & Luca Negri & Ferruccio Panzica & Laura M. Sangalli, 2023. "Analyzing data in complicated 3D domains: Smoothing, semiparametric regression, and functional principal component analysis," Biometrics, The International Biometric Society, vol. 79(4), pages 3510-3521, December.
    2. Israel Martínez‐Hernández & Marc G. Genton, 2021. "Nonparametric trend estimation in functional time series with application to annual mortality rates," Biometrics, The International Biometric Society, vol. 77(3), pages 866-878, September.
    3. Arnone, Eleonora & Azzimonti, Laura & Nobile, Fabio & Sangalli, Laura M., 2019. "Modeling spatially dependent functional data via regression with differential regularization," Journal of Multivariate Analysis, Elsevier, vol. 170(C), pages 275-295.
    4. Ferraccioli, Federico & Sangalli, Laura M. & Finos, Livio, 2022. "Some first inferential tools for spatial regression with differential regularization," Journal of Multivariate Analysis, Elsevier, vol. 189(C).
    5. Menafoglio, Alessandra & Secchi, Piercesare, 2017. "Statistical analysis of complex and spatially dependent data: A review of Object Oriented Spatial Statistics," European Journal of Operational Research, Elsevier, vol. 258(2), pages 401-410.
    6. Federico Ferraccioli & Eleonora Arnone & Livio Finos & James O. Ramsay & Laura M. Sangalli, 2021. "Nonparametric density estimation over complicated domains," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 83(2), pages 346-368, April.
    7. Bernardi, Mara S. & Carey, Michelle & Ramsay, James O. & Sangalli, Laura M., 2018. "Modeling spatial anisotropy via regression with partial differential regularization," Journal of Multivariate Analysis, Elsevier, vol. 167(C), pages 15-30.
    8. Lau, F. Din-Houn & Adams, Niall M. & Girolami, Mark A. & Butler, Liam J. & Elshafie, Mohammed Z.E.B., 2018. "The role of statistics in data-centric engineering," Statistics & Probability Letters, Elsevier, vol. 136(C), pages 58-62.

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