IDEAS home Printed from https://ideas.repec.org/a/taf/japsta/v36y2009i6p621-631.html
   My bibliography  Save this article

Analysis of microtubule dynamics using growth curve models

Author

Listed:
  • S. Rao Jammalamadaka
  • Md. Aleemuddin Siddiqi
  • Kaushik Ghosh

Abstract

Microtubules are part of the structural network within a cell's cytoplasm, providing structural support as well as taking part in many of the cellular processes. A large body of data provide evidence that dynamics of microtubules in a cell is reponsible for the performance of many critical cellular functions such as cell division. In this article, we study the effect of four different isoforms of a protein tau on microtubule dynamics using growth curve models. The results show that a linear growth curve model is sufficient to explain the data. Moreover, we find that a mutated version of a 3-repeat tau protein has a similar effect as a 4-repeat tau protein on microtubule dynamics. The latter findings conform with the biological understanding of the effect of the protein tau on microtubule dynamics.

Suggested Citation

  • S. Rao Jammalamadaka & Md. Aleemuddin Siddiqi & Kaushik Ghosh, 2009. "Analysis of microtubule dynamics using growth curve models," Journal of Applied Statistics, Taylor & Francis Journals, vol. 36(6), pages 621-631.
    • Handle: RePEc:taf:japsta:v:36:y:2009:i:6:p:621-631
    DOI: 10.1080/02664760802479131
    as

    Download full text from publisher

    File URL: http://www.tandfonline.com/doi/abs/10.1080/02664760802479131
    Download Restriction: Access to full text is restricted to subscribers.
    File URL: https://libkey.io/10.1080/02664760802479131?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Gareth M. James & Trevor J. Hastie, 2001. "Functional linear discriminant analysis for irregularly sampled curves," Journal of the Royal Statistical Society Series B, Royal Statistical Society, vol. 63(3), pages 533-550.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hongxiao Zhu & Philip J. Brown & Jeffrey S. Morris, 2012. "Robust Classification of Functional and Quantitative Image Data Using Functional Mixed Models," Biometrics, The International Biometric Society, vol. 68(4), pages 1260-1268, December.
    2. Jiménez Recaredo, Raúl José & Elías Fernández, Antonio, 2017. "Prediction Bands for Functional Data Based on Depth Measures," DES - Working Papers. Statistics and Econometrics. WS 24606, Universidad Carlos III de Madrid. Departamento de Estadística.
    3. Li, Pai-Ling & Chiou, Jeng-Min & Shyr, Yu, 2017. "Functional data classification using covariate-adjusted subspace projection," Computational Statistics & Data Analysis, Elsevier, vol. 115(C), pages 21-34.
    4. Carlo Sguera & Pedro Galeano & Rosa Lillo, 2014. "Spatial depth-based classification for functional data," TEST: An Official Journal of the Spanish Society of Statistics and Operations Research, Springer;Sociedad de Estadística e Investigación Operativa, vol. 23(4), pages 725-750, December.
    5. Zhang, Xin & Jeske, Daniel R. & Li, Jun & Wong, Vance, 2016. "A sequential logistic regression classifier based on mixed effects with applications to longitudinal data," Computational Statistics & Data Analysis, Elsevier, vol. 94(C), pages 238-249.
    6. Llop, P. & Forzani, L. & Fraiman, R., 2011. "On local times, density estimation and supervised classification from functional data," Journal of Multivariate Analysis, Elsevier, vol. 102(1), pages 73-86, January.
    7. Weishampel, Anthony & Staicu, Ana-Maria & Rand, William, 2023. "Classification of social media users with generalized functional data analysis," Computational Statistics & Data Analysis, Elsevier, vol. 179(C).
    8. Hidetoshi Matsui & Takamitsu Araki & Sadanori Konishi, 2011. "Multiclass Functional Discriminant Analysis and Its Application to Gesture Recognition," Journal of Classification, Springer;The Classification Society, vol. 28(2), pages 227-243, July.
    9. Cai, Wei & Guan, Guoyu & Pan, Rui & Zhu, Xuening & Wang, Hansheng, 2018. "Network linear discriminant analysis," Computational Statistics & Data Analysis, Elsevier, vol. 117(C), pages 32-44.
    10. Antonio Elías & Raúl Jiménez & Han Lin Shang, 2023. "Depth-based reconstruction method for incomplete functional data," Computational Statistics, Springer, vol. 38(3), pages 1507-1535, September.
    11. Andrés Alonso & David Casado & Sara López-Pintado & Juan Romo, 2014. "Robust Functional Supervised Classification for Time Series," Journal of Classification, Springer;The Classification Society, vol. 31(3), pages 325-350, October.
    12. Park, Yeonjoo & Simpson, Douglas G., 2019. "Robust probabilistic classification applicable to irregularly sampled functional data," Computational Statistics & Data Analysis, Elsevier, vol. 131(C), pages 37-49.
    13. M. P. Wand, 2003. "Smoothing and mixed models," Computational Statistics, Springer, vol. 18(2), pages 223-249, July.
    14. Marco Stefanucci & Laura M. Sangalli & Pierpaolo Brutti, 2018. "PCA‐based discrimination of partially observed functional data, with an application to AneuRisk65 data set," Statistica Neerlandica, Netherlands Society for Statistics and Operations Research, vol. 72(3), pages 246-264, August.
    15. Joseph, Esdras & Galeano San Miguel, Pedro & Lillo Rodríguez, Rosa Elvira, 2013. "The Mahalanobis distance for functional data with applications to classification," DES - Working Papers. Statistics and Econometrics. WS ws131312, Universidad Carlos III de Madrid. Departamento de Estadística.
    16. Zhang, Yi-Chen & Sakhanenko, Lyudmila, 2019. "The naive Bayes classifier for functional data," Statistics & Probability Letters, Elsevier, vol. 152(C), pages 137-146.
    17. Luigi Ippoliti & Simone Di Zio & Arcangelo Merla, 2014. "Classification of biomedical signals for differential diagnosis of Raynaud's phenomenon," Journal of Applied Statistics, Taylor & Francis Journals, vol. 41(8), pages 1830-1847, August.
    18. Olusola Samuel Makinde, 2019. "Classification rules based on distribution functions of functional depth," Statistical Papers, Springer, vol. 60(3), pages 629-640, June.
    19. Karl Mosler & Pavlo Mozharovskyi, 2017. "Fast DD-classification of functional data," Statistical Papers, Springer, vol. 58(4), pages 1055-1089, December.
    20. Manuel Escabias & Ana Aguilera & M. Aguilera-Morillo, 2014. "Functional PCA and Base-Line Logit Models," Journal of Classification, Springer;The Classification Society, vol. 31(3), pages 296-324, October.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:taf:japsta:v:36:y:2009:i:6:p:621-631. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Chris Longhurst (email available below). General contact details of provider: http://www.tandfonline.com/CJAS20 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.