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Experience-Based Swedish TTO and VAS Value Sets for EQ-5D-5L Health States

Author

Listed:
  • Kristina Burström

    (Karolinska Institutet
    Karolinska Institutet)

  • Fitsum Sebsibe Teni

    (Karolinska Institutet)

  • Ulf-G. Gerdtham

    (Lund University
    Lund University)

  • Reiner Leidl

    (German Research Center for Environmental Health
    Ludwig-Maximilians University)

  • Gert Helgesson

    (Karolinska Institutet)

  • Ola Rolfson

    (Karolinska Institutet
    University of Gothenburg
    Sahlgrenska University Hospital
    Centre of Registers Västra Götaland)

  • Martin Henriksson

    (Linköping University)

Abstract

Background and Objective Although value sets for the five-level version of the generic health-related quality-of-life instrument EQ-5D are emerging, there is still no value set available in the literature based on time trade-off valuations made by individuals experiencing the valued health states. The aim of this study was to estimate experience-based value sets for the EQ-5D-5L for Sweden using time trade-off and visual analogue scale valuation methods. Methods In a large, cross-sectional, population-based, self-administered postal health survey, the EQ-5D-5L descriptive system, EQ visual analogue scale and a time trade-off question were included. Time trade-off and visual analogue scale valuations of the respondent’s current health status were used in statistical modelling to estimate a single-index value of health for each of the 3125 health states. Ordinary least-squares and generalised linear models were estimated with the main effect within each of the five dimensions represented by 20 dummy variables reflecting the additional decrement in value for levels 2–5 when the severity increases by one level sequentially beginning from having no problem. Interaction variables representing the occurrence of severity levels in at least one of the dimensions were tested: severity level 2 or worse (N2); severity level 3 or worse (N3); severity level 4 or worse (N4); severity level 5 (N5). Results A total of 896 health states (28.7% of the 3125 possible EQ-5D-5L health states) were reported by the 25,867 respondents. Visual analogue scale (n = 23,899) and time trade-off (n = 13,381) responders reported valuations of their currently experienced health state. The preferred regression models used ordinary least-squares estimation for both time trade-off and visual analogue scale values and showed consistency in all coefficients after combining certain levels. Levels 4 and 5 for the dimensions of mobility, self-care and usual activities were combined in the time trade-off model. Including the interaction variable N5, indicating severity level 5 in at least one of the five dimensions, made it possible to distinguish between the two worst severity levels where no other dimension is at level 5 as this coefficient is applied only once. In the visual analogue scale regression model, levels 4 and 5 of the mobility dimension were combined. The interaction variables N2–N4 were included, indicating that each of these terms reflect a statistically significant decrement in visual analogue scale value if any of the dimensions is at severity level 2, 3 or 4, respectively. Conclusions Time trade-off and visual analogue scale value sets for the EQ-5D-5L are now available for Sweden. The time trade-off value set is the first such value set based on experience-based time trade-off valuation. For decision makers with a preference for experience-based valuations of health states from a representative population-based sample, the reported value sets may be considered fit for purpose to support resource allocation decision as well as evaluating population health and healthcare performance.

Suggested Citation

  • Kristina Burström & Fitsum Sebsibe Teni & Ulf-G. Gerdtham & Reiner Leidl & Gert Helgesson & Ola Rolfson & Martin Henriksson, 2020. "Experience-Based Swedish TTO and VAS Value Sets for EQ-5D-5L Health States," PharmacoEconomics, Springer, vol. 38(8), pages 839-856, August.
    • Handle: RePEc:spr:pharme:v:38:y:2020:i:8:d:10.1007_s40273-020-00905-7
    DOI: 10.1007/s40273-020-00905-7
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    References listed on IDEAS

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    1. Ogorevc, Marko & Murovec, Nika & Fernandez, Natacha Bolanos & Rupel, Valentina Prevolnik, 2019. "Questioning the differences between general public vs. patient based preferences towards EQ-5D-5L defined hypothetical health states," Health Policy, Elsevier, vol. 123(2), pages 166-172.
    2. Kristina Ludwig & J.-Matthias Graf von der Schulenburg & Wolfgang Greiner, 2018. "German Value Set for the EQ-5D-5L," PharmacoEconomics, Springer, vol. 36(6), pages 663-674, June.
    3. Burstrom, Kristina & Johannesson, Magnus & Diderichsen, Finn, 2006. "A comparison of individual and social time trade-off values for health states in the general population," Health Policy, Elsevier, vol. 76(3), pages 359-370, May.
    4. Patricia Cubi-Molla & Koonal Shah & Kristina Burström, 2018. "Experience-Based Values: A Framework for Classifying Different Types of Experience in Health Valuation Research," The Patient: Patient-Centered Outcomes Research, Springer;International Academy of Health Preference Research, vol. 11(3), pages 253-270, June.
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    1. Chris Sampson’s journal round-up for 3rd August 2020
      by Chris Sampson in The Academic Health Economists' Blog on 2020-08-03 11:00:00

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