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Methodological challenges in assessing the impact of comorbidities on costs in Alzheimer’s disease clinical trials

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  • Kristin Kahle-Wrobleski
  • Howard Fillit
  • Jonathan Kurlander
  • Catherine Reed
  • Mark Belger

Abstract

The number of comorbidities, alone or when combined with concomitant medications, did not impact baseline costs of care, perhaps because RCTs often enroll less severely ill and more medically stable patients. However, higher costs were consistently associated with greater functional impairment similar to non-RCT databases. Supplemental sources (e.g., claims databases) are likely needed to better estimate the effects of disease and treatment on costs of illness captured in RCTs for AD. Copyright The Author(s) 2015

Suggested Citation

  • Kristin Kahle-Wrobleski & Howard Fillit & Jonathan Kurlander & Catherine Reed & Mark Belger, 2015. "Methodological challenges in assessing the impact of comorbidities on costs in Alzheimer’s disease clinical trials," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 16(9), pages 995-1004, December.
    • Handle: RePEc:spr:eujhec:v:16:y:2015:i:9:p:995-1004
    DOI: 10.1007/s10198-014-0648-7
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    References listed on IDEAS

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    1. Denis Getsios & Kristen Migliaccio-Walle & Jaime Caro, 2007. "NICE Cost-Effectiveness Appraisal of Cholinesterase Inhibitors," PharmacoEconomics, Springer, vol. 25(12), pages 997-1006, December.
    2. Jerrold Hill & Howard Fillit & Simu Thomas & Sobin Chang, 2006. "Functional Impairment, Healthcare Costs and the Prevalence of Institutionalisation in Patients with Alzheimer’s Disease and Other Dementias," PharmacoEconomics, Springer, vol. 24(3), pages 265-280, March.
    3. Linus Jönsson & Anders Wimo, 2009. "The Cost of Dementia in Europe," PharmacoEconomics, Springer, vol. 27(5), pages 391-403, May.
    4. Johannesson, Magnus & Borgquis, Lars & Jonsson, Bengt & Rastam, Lennart, 1991. "The costs of treating hypertension -- an analysis of different cut-off points," Health Policy, Elsevier, vol. 18(2), pages 141-150, July.
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