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Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies

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  • Fei Li
  • Ce Zhu
  • Feng-Ying Deng
  • May Chun Mei Wong
  • Hai-Xia Lu
  • Xi-Ping Feng

Abstract

Objective: Previous studies have found that herpesviruses are associated with aggressive periodontitis (AgP). However, these findings are controversial. This meta-analysis was aimed at clarifying the association between herpesviruses and AgP. Methods: We identified eligible case–control studies evaluating the association between herpesviruses and AgP from PubMed and Embase databases in October 2015. Original data were extracted and quality assessment was done. Overall odds ratios (ORs) and 95% confidence intervals (CIs) were estimated. Random-effects model was determined. The stability was evaluated by sensitivity analysis. Finally, Egger’s funnel plot was used to investigate the publication bias. Results: Twelve case-control studies involving 322 patients and 342 controls were included in the present meta-analysis. The included case-control studies were assessed as high quality. The quantitative synthesis results for Epstein–Barr virus (EBV) showed significance (10 studies: p = 0.0008, OR = 6.11, 95% CI = 2.13–17.51); nevertheless, evidence of publication bias for EBV was considerable (EBV: Egger’s test, p

Suggested Citation

  • Fei Li & Ce Zhu & Feng-Ying Deng & May Chun Mei Wong & Hai-Xia Lu & Xi-Ping Feng, 2017. "Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.
    • Handle: RePEc:plo:pone00:0186373
    DOI: 10.1371/journal.pone.0186373
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    1. Ce Zhu & Fei Li & May Chun Mei Wong & Xi-Ping Feng & Hai-Xia Lu & Wei Xu, 2015. "Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
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