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Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies

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  • Ce Zhu
  • Fei Li
  • May Chun Mei Wong
  • Xi-Ping Feng
  • Hai-Xia Lu
  • Wei Xu

Abstract

Objective: Numerous studies have investigated the associations between herpesviruses and chronic periodontitis; however, the results remain controversial. To derive a more precise estimation, a meta-analysis on all available studies was performed to identify the association between herpesviruses and chronic periodontitis. Methods: A computerized literature search was conducted in December 2014 to identify eligible case-control studies from the PUBMED and EMBASE databases according to inclusion and exclusion criteria. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were used to assess the association between herpesviruses and risk of chronic periodontitis. A fixed or random effects model was determined based on a heterogeneity test. Sensitivity analysis was conducted to investigate stability and reliability. Publication bias was investigated using the Begg rank correlation test and Egger's funnel plot. Results: Ten eligible studies were included to investigate the association between Epstein–Barr virus (EBV) and chronic periodontitis. The results showed that EBV has a significant association with chronic periodontitis compared with periodontally healthy group (OR = 5.74, 95% CI = 2.53–13.00, P

Suggested Citation

  • Ce Zhu & Fei Li & May Chun Mei Wong & Xi-Ping Feng & Hai-Xia Lu & Wei Xu, 2015. "Association between Herpesviruses and Chronic Periodontitis: A Meta-Analysis Based on Case-Control Studies," PLOS ONE, Public Library of Science, vol. 10(12), pages 1-13, December.
    • Handle: RePEc:plo:pone00:0144319
    DOI: 10.1371/journal.pone.0144319
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    Cited by:

    1. Fei Li & Ce Zhu & Feng-Ying Deng & May Chun Mei Wong & Hai-Xia Lu & Xi-Ping Feng, 2017. "Herpesviruses in etiopathogenesis of aggressive periodontitis: A meta-analysis based on case-control studies," PLOS ONE, Public Library of Science, vol. 12(10), pages 1-13, October.

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