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Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer

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  • Ting Wang
  • Yang Liu
  • Li Sima
  • Liang Shi
  • Zhaoming Wang
  • Chunhui Ni
  • Zhengdong Zhang
  • Meilin Wang

Abstract

Background: The -93G>A (rs1800734) polymorphism located in the promoter of mismatch repair gene, MLH1, has been identified as a low-penetrance variant for cancer risk. Many published studies have evaluated the association between the MLH1 -93G>A polymorphism and colorectal cancer (CRC) risk. However, the results remain conflicting rather than conclusive. Objective: The aim of this study was to assess the association between the MLH1 -93G>A polymorphism and the risk of CRC. Methods: To derive a more precise estimation of the association, a meta-analysis of six studies (17,791 cases and 13,782 controls) was performed. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the strength of the association. Four of these published studies were performed on subjects of known microsatellite instability (MSI) status. An additional analysis including 742 cases and 10,895 controls was used to assess the association between the MLH1 -93G>A polymorphism and the risk of MSI-CRC. Results: The overall results indicated that the variant genotypes were associated with a significantly increased risk of CRC (AG versus GG: OR = 1.06, 95% CI = 1.01–1.11; AA/AG versus GG: OR = 1.06, 95% CI = 1.01–1.11). This increased risk was also found during stratified analysis of MSI status (AA versus GG: OR = 2.52, 95% CI = 1.94–3.28; AG versus GG: OR = 1.29, 95% CI = 1.10–1.52; AA/AG versus GG: OR = 1.45, 95% CI = 1.24–1.68; AA versus AG/GG: OR = 2.29, 95% CI = 1.78–2.96). Egger’s test did not show any evidence of publication bias. Conclusion: Our results suggest that the MLH1 -93G>A polymorphism may contribute to individual susceptibility to CRC and act as a risk factor for MSI-CRC.

Suggested Citation

  • Ting Wang & Yang Liu & Li Sima & Liang Shi & Zhaoming Wang & Chunhui Ni & Zhengdong Zhang & Meilin Wang, 2012. "Association between MLH1 -93G>A Polymorphism and Risk of Colorectal Cancer," PLOS ONE, Public Library of Science, vol. 7(11), pages 1-7, November.
    • Handle: RePEc:plo:pone00:0050449
    DOI: 10.1371/journal.pone.0050449
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    Cited by:

    1. Bin Wu & Kang Liu & Huaxing Huang & Jun Yuan & Wanqing Yuan & Shangqian Wang & Tingting Chen & Hu Zhao & Changjun Yin, 2013. "MspI and Ile462Val Polymorphisms in CYP1A1 and Overall Cancer Risk: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(12), pages 1-1, December.
    2. Bing-Hu Li & Li-Li Zhang & Bei-Bei Zhang & Yan-Wei Yin & Li-Meng Dai & Yan Pi & Lu Guo & Chang-Yue Gao & Chuan-Qin Fang & Jing-Zhou Wang & Jing-Cheng Li, 2013. "Association between NADPH Oxidase p22phox C242T Polymorphism and Ischemic Cerebrovascular Disease: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.

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