IDEAS home Printed from https://ideas.repec.org/a/plo/pone00/0044814.html
   My bibliography  Save this article

L-selectin and Skin Damage in Systemic Sclerosis

Author

Listed:
  • James V Dunne
  • Stephan F van Eeden
  • Kevin J Keen

Abstract

Background: L-selectin ligands are induced on the endothelium of inflammatory sites. L-selectin expression on neutrophils and monocytes may mediate the primary adhesion of these cells at sites of inflammation by mediating the leukocyte-leukocyte interactions that facilitate their recruitment. L-selectin retains functional activity in its soluble form. Levels of soluble L-selectin have been reported as both elevated and lowered in patients with systemic sclerosis (SSc). This preliminary study seeks to discern amongst these disparate results and to discover whether there is an association between L-selectin concentrations in plasma and skin damage in SSc patients. Methodology and Principal Findings: Nineteen cases with limited systemic sclerosis (lSSc) and 11 cases with diffuse systemic sclerosis (dSSc) were compared on a pairwise basis to age- and sex-matched controls. Criteria of the American College of Rheumatology were used to diagnose SSc. Skin involvement was assessed using the modified Rodnan skin score (mRSS). We find no association between mRSS and plasma L-selectin concentration in lSSc cases (p = 0.9944) but a statistically significant negative correlation in dSSc cases (R2 = 73.11 per cent, p = 0.0008). The interpretation of the slope for dSSc cases is that for each increase of 100 ng/ml in soluble L-selectin concentration, the mRSS drops 4.22 (95 per cent CI: 2.29, 6.16). There was also a highly statistically significant negative correlation between sL-selectin and disease activity (p = 0.0007) and severity (p = 0.0007) in dSSc cases but not in lSSc cases (p = 0.2596, p = 0.7575, respectively). Conclusions and Significance: No effective treatments exist for skin damage in SSc patients. Nor is there a laboratory alternative to the modified Rodnan skin score as is the case for other organs within the body. Modulation of circulating L-selectin is a promising target for reducing skin damage in dSSc patients. Plasma levels of soluble L-selectin could serve as an outcome measure for dSSc patients in clinical trials.

Suggested Citation

  • James V Dunne & Stephan F van Eeden & Kevin J Keen, 2012. "L-selectin and Skin Damage in Systemic Sclerosis," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-8, September.
    • Handle: RePEc:plo:pone00:0044814
    DOI: 10.1371/journal.pone.0044814
    as

    Download full text from publisher

    File URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044814
    Download Restriction: no
    File URL: https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0044814&type=printable
    Download Restriction: no
    File URL: https://libkey.io/10.1371/journal.pone.0044814?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Hothorn, Torsten & Hornik, Kurt & van de Wiel, Mark A. & Zeileis, Achim, 2008. "Implementing a Class of Permutation Tests: The coin Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 28(i08).
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Brosig-Koch, Jeannette & Griebenow, Malte & Kifmann, Mathias & Then, Franziska, 2022. "Rewards for information provision in patient referrals: A theoretical model and an experimental test," Journal of Health Economics, Elsevier, vol. 86(C).
    2. repec:jss:jstsof:36:i02 is not listed on IDEAS
    3. McGinlay, James & Parsons, David J. & Morris, Joe & Hubatova, Marie & Graves, Anil & Bradbury, Richard B. & Bullock, James M., 2017. "Do charismatic species groups generate more cultural ecosystem service benefits?," Ecosystem Services, Elsevier, vol. 27(PA), pages 15-24.
    4. repec:jss:jstsof:34:i01 is not listed on IDEAS
    5. Zeileis, Achim & Croissant, Yves, 2010. "Extended Model Formulas in R: Multiple Parts and Multiple Responses," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 34(i01).
    6. Nordhausen, Klaus & Oja, Hannu, 2011. "Multivariate L1 Statistical Methods: The Package MNM," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 43(i05).
    7. Achim Zeileis & Torsten Hothorn, 2013. "A toolbox of permutation tests for structural change," Statistical Papers, Springer, vol. 54(4), pages 931-954, November.
    8. McGinlay, James & Parsons, David J. & Morris, Joe & Graves, Anil & Hubatova, Marie & Bradbury, Richard B. & Bullock, James M., 2018. "Leisure activities and social factors influence the generation of cultural ecosystem service benefits," Ecosystem Services, Elsevier, vol. 31(PC), pages 468-480.
    9. Maldonado, A.D. & Aguilera, P.A. & Salmerón, A. & Nicholson, A.E., 2018. "Probabilistic modeling of the relationship between socioeconomy and ecosystem services in cultural landscapes," Ecosystem Services, Elsevier, vol. 33(PB), pages 146-164.
    10. Fay, Michael P. & Shaw, Pamela A., 2010. "Exact and Asymptotic Weighted Logrank Tests for Interval Censored Data: The interval R Package," Journal of Statistical Software, Foundation for Open Access Statistics, vol. 36(i02).
    11. O'Sullivan, Kimberley C. & Stanley, James & Fougere, Geoffrey & Howden-Chapman, Philippa, 2016. "Heating practices and self-disconnection among electricity prepayment meter consumers in New Zealand: A follow-up survey," Utilities Policy, Elsevier, vol. 41(C), pages 139-147.
    12. Harinder Singh & Sandeep Singh & Gajendra P S Raghava, 2014. "Evaluation of Protein Dihedral Angle Prediction Methods," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-9, August.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:plo:pone00:0044814. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: plosone (email available below). General contact details of provider: https://journals.plos.org/plosone/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.