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RGF1 controls root meristem size through ROS signalling

Author

Listed:
  • Masashi Yamada

    (Duke University
    Academia Sinica
    Academia Sinica)

  • Xinwei Han

    (Duke University
    GlaxoSmithKline)

  • Philip N. Benfey

    (Duke University)

Abstract

The stem cell niche and the size of the root meristem in plants are maintained by intercellular interactions and signalling networks involving a peptide hormone, root meristem growth factor 1 (RGF1)1. Understanding how RGF1 regulates the development of the root meristem is essential for understanding stem cell function. Although five receptors for RGF1 have been identified2–4, the downstream signalling mechanism remains unknown. Here we report a series of signalling events that follow RGF1 activity. We find that the RGF1-receptor pathway controls the distribution of reactive oxygen species (ROS) along the developmental zones of the Arabidopsis root. We identify a previously uncharacterized transcription factor, RGF1-INDUCIBLE TRANSCRIPTION FACTOR 1 (RITF1), that has a central role in mediating RGF1 signalling. Manipulating RITF1 expression leads to the redistribution of ROS along the root developmental zones. Changes in ROS distribution in turn enhance the stability of the PLETHORA2 protein, a master regulator of root stem cells. Our results thus clearly depict a signalling cascade that is initiated by RGF1, linking this peptide to mechanisms that regulate ROS.

Suggested Citation

  • Masashi Yamada & Xinwei Han & Philip N. Benfey, 2020. "RGF1 controls root meristem size through ROS signalling," Nature, Nature, vol. 577(7788), pages 85-88, January.
    • Handle: RePEc:nat:nature:v:577:y:2020:i:7788:d:10.1038_s41586-019-1819-6
    DOI: 10.1038/s41586-019-1819-6
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    Cited by:

    1. Gilad Gabay & Hanchao Wang & Junli Zhang & Jorge I. Moriconi & German F. Burguener & Leonardo D. Gualano & Tyson Howell & Adam Lukaszewski & Brian Staskawicz & Myeong-Je Cho & Jaclyn Tanaka & Tzion Fa, 2023. "Dosage differences in 12-OXOPHYTODIENOATE REDUCTASE genes modulate wheat root growth," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Tao Zhang & Sarah E. Noll & Jesus T. Peng & Amman Klair & Abigail Tripka & Nathan Stutzman & Casey Cheng & Richard N. Zare & Alexandra J. Dickinson, 2023. "Chemical imaging reveals diverse functions of tricarboxylic acid metabolites in root growth and development," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    3. Ping Li & Nana Xu & Yang Shui & Jie Zhang & Wuzhong Yin & Min Tian & Faping Guo & Dasong Bai & Pan Qi & Qingxiong Huang & Biluo Li & Yuanyuan Li & Yungao Hu & Youlin Peng, 2023. "Phenotypic Analysis and Gene Cloning of a New Allelic Mutant of SPL5 in Rice," Agriculture, MDPI, vol. 13(10), pages 1-16, September.
    4. Wen Shi & Lingyan Wang & Lianmei Yao & Wei Hao & Chao Han & Min Fan & Wenfei Wang & Ming-Yi Bai, 2022. "Spatially patterned hydrogen peroxide orchestrates stomatal development in Arabidopsis," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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