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Cytosolic proteostasis through importing of misfolded proteins into mitochondria

Author

Listed:
  • Linhao Ruan

    (Center for Cell Dynamics, Johns Hopkins University School of Medicine
    Whiting School of Engineering, Johns Hopkins University)

  • Chuankai Zhou

    (Stowers Institute for Medical Research)

  • Erli Jin

    (Whiting School of Engineering, Johns Hopkins University)

  • Andrei Kucharavy

    (Center for Cell Dynamics, Johns Hopkins University School of Medicine
    Whiting School of Engineering, Johns Hopkins University)

  • Ying Zhang

    (Stowers Institute for Medical Research)

  • Zhihui Wen

    (Stowers Institute for Medical Research)

  • Laurence Florens

    (Stowers Institute for Medical Research)

  • Rong Li

    (Center for Cell Dynamics, Johns Hopkins University School of Medicine
    Whiting School of Engineering, Johns Hopkins University)

Abstract

Proteins prone to aggregation in yeast are imported into mitochondria under stress conditions, suggesting that mitochondrial import and proteolysis may help to disaggregate proteins in the cytoplasm.

Suggested Citation

  • Linhao Ruan & Chuankai Zhou & Erli Jin & Andrei Kucharavy & Ying Zhang & Zhihui Wen & Laurence Florens & Rong Li, 2017. "Cytosolic proteostasis through importing of misfolded proteins into mitochondria," Nature, Nature, vol. 543(7645), pages 443-446, March.
    • Handle: RePEc:nat:nature:v:543:y:2017:i:7645:d:10.1038_nature21695
    DOI: 10.1038/nature21695
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    Citations

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    Cited by:

    1. Rebecca V Walker & Qin Yao & Hangxue Xu & Anthony Maranto & Kristen F Swaney & Sreekumar Ramachandran & Rong Li & Laura Cassina & Brian M Polster & Patricia Outeda & Alessandra Boletta & Terry Watnick, 2023. "Fibrocystin/Polyductin releases a C-terminal fragment that translocates into mitochondria and suppresses cystogenesis," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    2. Pascale Baden & Maria Jose Perez & Hariam Raji & Federico Bertoli & Stefanie Kalb & María Illescas & Fokion Spanos & Claudio Giuliano & Alessandra Maria Calogero & Marvin Oldrati & Hannah Hebestreit &, 2023. "Glucocerebrosidase is imported into mitochondria and preserves complex I integrity and energy metabolism," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    3. Sibiao Yue & Lei Wang & George N. DeMartino & FangZhou Zhao & Yi Liu & Matthew H. Sieber, 2022. "Highly conserved shifts in ubiquitin-proteasome system (UPS) activity drive mitochondrial remodeling during quiescence," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    4. Arthur Fischbach & Angela Johns & Kara L. Schneider & Xinxin Hao & Peter Tessarz & Thomas Nyström, 2023. "Artificial Hsp104-mediated systems for re-localizing protein aggregates," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Eirini Lionaki & Ilias Gkikas & Ioanna Daskalaki & Maria-Konstantina Ioannidi & Maria I. Klapa & Nektarios Tavernarakis, 2022. "Mitochondrial protein import determines lifespan through metabolic reprogramming and de novo serine biosynthesis," Nature Communications, Nature, vol. 13(1), pages 1-16, December.

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