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Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor

Author

Listed:
  • Shin Isogai

    (Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel)

  • Xavier Deupi

    (Paul Scherrer Institute)

  • Christian Opitz

    (Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel)

  • Franziska M. Heydenreich

    (Paul Scherrer Institute)

  • Ching-Ju Tsai

    (Paul Scherrer Institute)

  • Florian Brueckner

    (Paul Scherrer Institute)

  • Gebhard F. X. Schertler

    (Paul Scherrer Institute
    Department of Biology)

  • Dmitry B. Veprintsev

    (Paul Scherrer Institute
    Department of Biology)

  • Stephan Grzesiek

    (Focal Area Structural Biology and Biophysics, Biozentrum, University of Basel)

Abstract

Although several X-ray crystal structures of G protein-coupled receptors (GPCRs) have been reported, relatively little is known about the conformational dynamics of these important membrane proteins; here, the authors used NMR spectroscopy to monitor the conformational changes that occur in the turkey β1-adrenergic receptor in the presence of antagonists, partial agonists, and full agonists.

Suggested Citation

  • Shin Isogai & Xavier Deupi & Christian Opitz & Franziska M. Heydenreich & Ching-Ju Tsai & Florian Brueckner & Gebhard F. X. Schertler & Dmitry B. Veprintsev & Stephan Grzesiek, 2016. "Backbone NMR reveals allosteric signal transduction networks in the β1-adrenergic receptor," Nature, Nature, vol. 530(7589), pages 237-241, February.
    • Handle: RePEc:nat:nature:v:530:y:2016:i:7589:d:10.1038_nature16577
    DOI: 10.1038/nature16577
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    Cited by:

    1. Andrew J. Y. Jones & Thomas H. Harman & Matthew Harris & Oliver E. Lewis & Graham Ladds & Daniel Nietlispach, 2024. "Binding kinetics drive G protein subtype selectivity at the β1-adrenergic receptor," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Jun Xu & Qinggong Wang & Harald Hübner & Yunfei Hu & Xiaogang Niu & Haoqing Wang & Shoji Maeda & Asuka Inoue & Yuyong Tao & Peter Gmeiner & Yang Du & Changwen Jin & Brian K. Kobilka, 2023. "Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yuan Liang & Yunkai Qie & Jing Yang & Ranfeng Wu & Shuang Cui & Yuliang Zhao & Greg J. Anderson & Guangjun Nie & Suping Li & Cheng Zhang, 2023. "Programming conformational cooperativity to regulate allosteric protein-oligonucleotide signal transduction," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Minfei Su & Navid Paknejad & Lan Zhu & Jinan Wang & Hung Nguyen Do & Yinglong Miao & Wei Liu & Richard K. Hite & Xin-Yun Huang, 2022. "Structures of β1-adrenergic receptor in complex with Gs and ligands of different efficacies," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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