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A synaptic and circuit basis for corollary discharge in the auditory cortex

Author

Listed:
  • David M. Schneider

    (Duke University School of Medicine)

  • Anders Nelson

    (Duke University School of Medicine)

  • Richard Mooney

    (Duke University School of Medicine)

Abstract

Sensory regions of the brain integrate environmental cues with copies of motor-related signals important for imminent and ongoing movements. In mammals, signals propagating from the motor cortex to the auditory cortex are thought to have a critical role in normal hearing and behaviour, yet the synaptic and circuit mechanisms by which these motor-related signals influence auditory cortical activity remain poorly understood. Using in vivo intracellular recordings in behaving mice, we find that excitatory neurons in the auditory cortex are suppressed before and during movement, owing in part to increased activity of local parvalbumin-positive interneurons. Electrophysiology and optogenetic gain- and loss-of-function experiments reveal that motor-related changes in auditory cortical dynamics are driven by a subset of neurons in the secondary motor cortex that innervate the auditory cortex and are active during movement. These findings provide a synaptic and circuit basis for the motor-related corollary discharge hypothesized to facilitate hearing and auditory-guided behaviours.

Suggested Citation

  • David M. Schneider & Anders Nelson & Richard Mooney, 2014. "A synaptic and circuit basis for corollary discharge in the auditory cortex," Nature, Nature, vol. 513(7517), pages 189-194, September.
    • Handle: RePEc:nat:nature:v:513:y:2014:i:7517:d:10.1038_nature13724
    DOI: 10.1038/nature13724
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    Cited by:

    1. Evan S. Schaffer & Neeli Mishra & Matthew R. Whiteway & Wenze Li & Michelle B. Vancura & Jason Freedman & Kripa B. Patel & Venkatakaushik Voleti & Liam Paninski & Elizabeth M. C. Hillman & L. F. Abbot, 2023. "The spatial and temporal structure of neural activity across the fly brain," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    2. Zhaoran Zhang & Edward Zagha, 2023. "Motor cortex gates distractor stimulus encoding in sensory cortex," Nature Communications, Nature, vol. 14(1), pages 1-17, December.
    3. Francisco García-Rosales & Luciana López-Jury & Eugenia González-Palomares & Johannes Wetekam & Yuranny Cabral-Calderín & Ava Kiai & Manfred Kössl & Julio C. Hechavarría, 2022. "Echolocation-related reversal of information flow in a cortical vocalization network," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    4. Roberto de la Torre-Martinez & Maya Ketzef & Gilad Silberberg, 2023. "Ongoing movement controls sensory integration in the dorsolateral striatum," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    5. Christopher F. Angeloni & Wiktor Młynarski & Eugenio Piasini & Aaron M. Williams & Katherine C. Wood & Linda Garami & Ann M. Hermundstad & Maria N. Geffen, 2023. "Dynamics of cortical contrast adaptation predict perception of signals in noise," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    6. Brian P. Rummell & Solmaz Bikas & Susanne S. Babl & Joseph A. Gogos & Torfi Sigurdsson, 2023. "Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Bartul Mimica & Tuçe Tombaz & Claudia Battistin & Jingyi Guo Fuglstad & Benjamin A. Dunn & Jonathan R. Whitlock, 2023. "Behavioral decomposition reveals rich encoding structure employed across neocortex in rats," Nature Communications, Nature, vol. 14(1), pages 1-20, December.

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