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Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition

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  • Brian P. Rummell

    (Goethe University
    Ernst Strüngmann Institute (ESI) for Neuroscience in Cooperation with Max Planck Society)

  • Solmaz Bikas

    (Goethe University)

  • Susanne S. Babl

    (Goethe University)

  • Joseph A. Gogos

    (Columbia University
    Columbia University)

  • Torfi Sigurdsson

    (Goethe University)

Abstract

The ability to distinguish sensations that are self-generated from those caused by external events is disrupted in schizophrenia patients. However, the neural circuit abnormalities underlying this sensory impairment and its relationship to the risk factors for the disease is not well understood. To address this, we examined the processing of self-generated sounds in male Df(16)A+/− mice, which model one of the largest genetic risk factors for schizophrenia, the 22q11.2 microdeletion. We find that auditory cortical neurons in Df(16)A+/− mice fail to attenuate their responses to self-generated sounds, recapitulating deficits seen in schizophrenia patients. Notably, the auditory cortex of Df(16)A+/− mice displayed weaker motor-related signals and received fewer inputs from the motor cortex, suggesting an anatomical basis underlying the sensory deficit. These results provide insights into the mechanisms by which a major genetic risk factor for schizophrenia disrupts the top-down processing of sensory information.

Suggested Citation

  • Brian P. Rummell & Solmaz Bikas & Susanne S. Babl & Joseph A. Gogos & Torfi Sigurdsson, 2023. "Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-42964-2
    DOI: 10.1038/s41467-023-42964-2
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    References listed on IDEAS

    as
    1. Steven J. Eliades & Xiaoqin Wang, 2008. "Neural substrates of vocalization feedback monitoring in primate auditory cortex," Nature, Nature, vol. 453(7198), pages 1102-1106, June.
    2. Torfi Sigurdsson & Kimberly L. Stark & Maria Karayiorgou & Joseph A. Gogos & Joshua A. Gordon, 2010. "Impaired hippocampal–prefrontal synchrony in a genetic mouse model of schizophrenia," Nature, Nature, vol. 464(7289), pages 763-767, April.
    3. David M. Schneider & Anders Nelson & Richard Mooney, 2014. "A synaptic and circuit basis for corollary discharge in the auditory cortex," Nature, Nature, vol. 513(7517), pages 189-194, September.
    4. Koun Onodera & Hiroyuki K. Kato, 2022. "Translaminar recurrence from layer 5 suppresses superficial cortical layers," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
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