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Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity

Author

Listed:
  • Tae-Hee Kim

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Fugen Li

    (Dana-Farber Cancer Institute)

  • Isabel Ferreiro-Neira

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Li-Lun Ho

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Annouck Luyten

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Kodandaramireddy Nalapareddy

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Henry Long

    (Dana-Farber Cancer Institute)

  • Michael Verzi

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

  • Ramesh A. Shivdasani

    (Dana-Farber Cancer Institute
    Brigham and Women’s Hospital and Harvard Medical School)

Abstract

A study investigating the mechanisms underlying lateral inhibition and lineage plasticity in the mouse small intestine crypts in vivo finds that crypt cells maintain a permissive chromatin state upon which a transcription factor acts to determine lineage specification, and this is the basis of lateral inhibition.

Suggested Citation

  • Tae-Hee Kim & Fugen Li & Isabel Ferreiro-Neira & Li-Lun Ho & Annouck Luyten & Kodandaramireddy Nalapareddy & Henry Long & Michael Verzi & Ramesh A. Shivdasani, 2014. "Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity," Nature, Nature, vol. 506(7489), pages 511-515, February.
    • Handle: RePEc:nat:nature:v:506:y:2014:i:7489:d:10.1038_nature12903
    DOI: 10.1038/nature12903
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    Cited by:

    1. Xingting Guo & Chenhui Wang & Yongchao Zhang & Ruxue Wei & Rongwen Xi, 2024. "Cell-fate conversion of intestinal cells in adult Drosophila midgut by depleting a single transcription factor," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    2. Omid Omrani & Anna Krepelova & Seyed Mohammad Mahdi Rasa & Dovydas Sirvinskas & Jing Lu & Francesco Annunziata & George Garside & Seerat Bajwa & Susanne Reinhardt & Lisa Adam & Sandra Käppel & Nadia D, 2023. "IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Ryan J. Smith & Minggao Liang & Adrian Kwan Ho Loe & Theodora Yung & Ji-Eun Kim & Matthew Hudson & Michael D. Wilson & Tae-Hee Kim, 2023. "Epigenetic control of cellular crosstalk defines gastrointestinal organ fate and function," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    4. Wei Gu & Xiaofeng Huang & Pratik N. P. Singh & Sanlan Li & Ying Lan & Min Deng & Lauretta A. Lacko & Jesus M. Gomez-Salinero & Shahin Rafii & Michael P. Verzi & Ramesh A. Shivdasani & Qiao Zhou, 2024. "A MTA2-SATB2 chromatin complex restrains colonic plasticity toward small intestine by retaining HNF4A at colonic chromatin," Nature Communications, Nature, vol. 15(1), pages 1-16, December.

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