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Natural RNA circles function as efficient microRNA sponges

Author

Listed:
  • Thomas B. Hansen

    (Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark)

  • Trine I. Jensen

    (Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark)

  • Bettina H. Clausen

    (Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløwsvej 25, 5000C, Odense, Denmark)

  • Jesper B. Bramsen

    (Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark
    Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wiedsvej 14, 8000C, Aarhus, Denmark)

  • Bente Finsen

    (Neurobiology Research, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsløwsvej 25, 5000C, Odense, Denmark)

  • Christian K. Damgaard

    (Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark)

  • Jørgen Kjems

    (Aarhus University, C.F. Møllers Alle 3, 8000C, Aarhus, Denmark
    Interdisciplinary Nanoscience Center (iNANO), Aarhus University, Gustav Wiedsvej 14, 8000C, Aarhus, Denmark)

Abstract

A natural circular RNA termed ciRS-7 is shown to function as a negative regulator of microRNA; ciRS-7 acts as an efficient sponge for the microRNA miR-7, and is resistant to the usual microRNA-mediated degradation pathway of exonucleolytic RNA decay.

Suggested Citation

  • Thomas B. Hansen & Trine I. Jensen & Bettina H. Clausen & Jesper B. Bramsen & Bente Finsen & Christian K. Damgaard & Jørgen Kjems, 2013. "Natural RNA circles function as efficient microRNA sponges," Nature, Nature, vol. 495(7441), pages 384-388, March.
    • Handle: RePEc:nat:nature:v:495:y:2013:i:7441:d:10.1038_nature11993
    DOI: 10.1038/nature11993
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    Cited by:

    1. Humberto J. Ferreira & Brian J. Stevenson & HuiSong Pak & Fengchao Yu & Jessica Almeida Oliveira & Florian Huber & Marie Taillandier-Coindard & Justine Michaux & Emma Ricart-Altimiras & Anne I. Kraeme, 2024. "Immunopeptidomics-based identification of naturally presented non-canonical circRNA-derived peptides," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Zhenzhen Chen & Qiankun He & Tiankun Lu & Jiayi Wu & Gaoli Shi & Luyun He & Hong Zong & Benyu Liu & Pingping Zhu, 2023. "mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Federica Conte & Giulia Fiscon & Matteo Chiara & Teresa Colombo & Lorenzo Farina & Paola Paci, 2017. "Role of the long non-coding RNA PVT1 in the dysregulation of the ceRNA-ceRNA network in human breast cancer," PLOS ONE, Public Library of Science, vol. 12(2), pages 1-22, February.
    4. Ting-Ting He & Yun-Fan Xu & Xiang Li & Xia Wang & Jie-Yu Li & Dan Ou-Yang & Han-Sen Cheng & Hao-Yang Li & Jia Qin & Yu Huang & Hai-Yan Wang, 2023. "A linear and circular dual-conformation noncoding RNA involved in oxidative stress tolerance in Bacillus altitudinis," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
    5. Xiujuan Lei & Wenxiang Zhang, 2019. "BRWSP: Predicting circRNA-Disease Associations Based on Biased Random Walk to Search Paths on a Multiple Heterogeneous Network," Complexity, Hindawi, vol. 2019, pages 1-12, November.
    6. Yu Dong & Qian Gao & Yong Chen & Zhao Zhang & Yanhua Du & Yuan Liu & Guangxiong Zhang & Shengli Li & Gaoyang Wang & Xiang Chen & Hong Liu & Leng Han & Youqiong Ye, 2023. "Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy," Nature Communications, Nature, vol. 14(1), pages 1-15, December.
    7. Bin Li & Wen-Wu Bai & Tao Guo & Zhen-Yu Tang & Xue-Jiao Jing & Ti-Chao Shan & Sen Yin & Ying Li & Fu Wang & Mo-Li Zhu & Jun-Xiu Lu & Yong-Ping Bai & Bo Dong & Peng Li & Shuang-Xi Wang, 2024. "Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    8. Steffen Fuchs & Clara Danßmann & Filippos Klironomos & Annika Winkler & Jörg Fallmann & Louisa-Marie Kruetzfeldt & Annabell Szymansky & Julian Naderi & Stephan H. Bernhart & Laura Grunewald & Konstant, 2023. "Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN," Nature Communications, Nature, vol. 14(1), pages 1-21, December.
    9. Xiaojuan Fan & Yun Yang & Chuyun Chen & Zefeng Wang, 2022. "Pervasive translation of circular RNAs driven by short IRES-like elements," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    10. Roberta Piras & Emily Y. Ko & Connor Barrett & Marco Simone & Xianzhi Lin & Marina T. Broz & Fernando H. G. Tessaro & Mireia Castillo-Martin & Carlos Cordon-Cardo & Helen S. Goodridge & Dolores Vizio , 2022. "circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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