IDEAS home Printed from https://ideas.repec.org/a/nat/nature/v480y2011i7375d10.1038_nature10653.html
   My bibliography  Save this article

Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis

Author

Listed:
  • Khoa D. Nguyen

    (Immunology Program, Stanford University
    Cardiovascular Research Institute, University of California)

  • Yifu Qiu

    (Cardiovascular Research Institute, University of California)

  • Xiaojin Cui

    (Cardiovascular Research Institute, University of California)

  • Y. P. Sharon Goh

    (Immunology Program, Stanford University
    Cardiovascular Research Institute, University of California)

  • Julia Mwangi

    (Cardiovascular Research Institute, University of California)

  • Tovo David

    (Cardiovascular Research Institute, University of California)

  • Lata Mukundan

    (Cardiovascular Research Institute, University of California)

  • Frank Brombacher

    (Institute of Infectious Disease and Molecular Medicine, University of Cape Town)

  • Richard M. Locksley

    (Howard Hughes Medical Institute, University of California
    University of California
    Microbiology & Immunology, University of California)

  • Ajay Chawla

    (Cardiovascular Research Institute, University of California
    University of California)

Abstract

Exposure to cold drives IL-4-mediated alternative macrophage activation and catecholamine secretion in brown and white adipose tissues to stimulate thermogenesis.

Suggested Citation

  • Khoa D. Nguyen & Yifu Qiu & Xiaojin Cui & Y. P. Sharon Goh & Julia Mwangi & Tovo David & Lata Mukundan & Frank Brombacher & Richard M. Locksley & Ajay Chawla, 2011. "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis," Nature, Nature, vol. 480(7375), pages 104-108, December.
  • Handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10653
    DOI: 10.1038/nature10653
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/nature10653
    File Function: Abstract
    Download Restriction: Access to the full text of the articles in this series is restricted.

    File URL: https://libkey.io/10.1038/nature10653?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Suyang Wu & Chen Qiu & Jiahao Ni & Wenli Guo & Jiyuan Song & Xingyin Yang & Yulin Sun & Yanjun Chen & Yunxia Zhu & Xiaoai Chang & Peng Sun & Chunxia Wang & Kai Li & Xiao Han, 2024. "M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Natasha M Girgis & Uma Mahesh Gundra & Lauren N Ward & Mynthia Cabrera & Ute Frevert & P'ng Loke, 2014. "Ly6Chigh Monocytes Become Alternatively Activated Macrophages in Schistosome Granulomas with Help from CD4+ Cells," PLOS Pathogens, Public Library of Science, vol. 10(6), pages 1-13, June.
    3. Prameladevi Chinnasamy & Isabel Casimiro & Dario F. Riascos-Bernal & Shreeganesh Venkatesh & Dippal Parikh & Alishba Maira & Aparna Srinivasan & Wei Zheng & Elena Tarabra & Haihong Zong & Smitha Jayak, 2023. "Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Shaojian Lin & Anke Zhang & Ling Yuan & Yufan Wang & Chuan Zhang & Junkun Jiang & Houshi Xu & Huiwen Yuan & Hui Yao & Qianying Zhang & Yong Zhang & Meiqing Lou & Ping Wang & Zhen-Ning Zhang & Bing Lua, 2022. "Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    5. Jing Yan & Yuemei Zhang & Hairong Yu & Yicen Zong & Daixi Wang & Jiangfei Zheng & Li Jin & Xiangtian Yu & Caizhi Liu & Yi Zhang & Feng Jiang & Rong Zhang & Xiangnan Fang & Ting Xu & Mingyu Li & Jianzh, 2022. "GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    6. Xian Zhang & Songyuan Luo & Minjie Wang & Qiongqiong Cao & Zhixin Zhang & Qin Huang & Jie Li & Zhiyong Deng & Tianxiao Liu & Cong-Lin Liu & Mathilde Meppen & Amelie Vromman & Richard A. Flavell & Gökh, 2022. "Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:nature:v:480:y:2011:i:7375:d:10.1038_nature10653. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.