IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-022-35683-7.html
   My bibliography  Save this article

Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1

Author

Listed:
  • Prameladevi Chinnasamy

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine)

  • Isabel Casimiro

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine)

  • Dario F. Riascos-Bernal

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine)

  • Shreeganesh Venkatesh

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine)

  • Dippal Parikh

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine)

  • Alishba Maira

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine)

  • Aparna Srinivasan

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine)

  • Wei Zheng

    (Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Albert Einstein Cancer Center, Albert Einstein College of Medicine)

  • Elena Tarabra

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine
    Department of Medicine (Endocrinology, Albert Einstein College of Medicine))

  • Haihong Zong

    (Department of Medicine (Endocrinology, Albert Einstein College of Medicine)
    Einstein-Mount Sinai Diabetes Research Center and Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine)

  • Smitha Jayakumar

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine)

  • Venkatesh Jeganathan

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine)

  • Kith Pradan

    (Albert Einstein College of Medicine)

  • Jose O. Aleman

    (New York University Langone Health)

  • Rajat Singh

    (Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Department of Medicine (Endocrinology, Albert Einstein College of Medicine)
    Einstein-Mount Sinai Diabetes Research Center and Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine)

  • Sayan Nandi

    (Department of Developmental and Molecular Biology, Albert Einstein College of Medicine)

  • Jeffrey E. Pessin

    (Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Department of Molecular Pharmacology, Albert Einstein College of Medicine
    Einstein-Mount Sinai Diabetes Research Center and Fleischer Institute of Diabetes and Metabolism, Albert Einstein College of Medicine)

  • Nicholas E. S. Sibinga

    (Department of Medicine (Cardiology), Albert Einstein College of Medicine
    Department of Developmental and Molecular Biology, Albert Einstein College of Medicine
    Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine
    Albert Einstein Cancer Center, Albert Einstein College of Medicine)

Abstract

Recent studies implicate macrophages in regulation of thermogenic, sympathetic neuron-mediated norepinephrine (NE) signaling in adipose tissues, but understanding of such non-classical macrophage activities is incomplete. Here we show that male mice lacking the allograft inflammatory factor-1 (AIF1) protein resist high fat diet (HFD)-induced obesity and hyperglycemia. We link this phenotype to higher adipose NE levels that stem from decreased monoamine oxidase A (MAOA) expression and NE clearance by AIF1-deficient macrophages, and find through reciprocal bone marrow transplantation that donor Aif1-/- vs WT genotype confers the obesity phenotype in mice. Interestingly, human sequence variants near the AIF1 locus associate with obesity and diabetes; in adipose samples from participants with obesity, we observe direct correlation of AIF1 and MAOA transcript levels. These findings identify AIF1 as a regulator of MAOA expression in macrophages and catecholamine activity in adipose tissues – limiting energy expenditure and promoting energy storage – and suggest how it might contribute to human obesity.

Suggested Citation

  • Prameladevi Chinnasamy & Isabel Casimiro & Dario F. Riascos-Bernal & Shreeganesh Venkatesh & Dippal Parikh & Alishba Maira & Aparna Srinivasan & Wei Zheng & Elena Tarabra & Haihong Zong & Smitha Jayak, 2023. "Increased adipose catecholamine levels and protection from obesity with loss of Allograft Inflammatory Factor-1," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35683-7
    DOI: 10.1038/s41467-022-35683-7
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-022-35683-7
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-022-35683-7?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Khoa D. Nguyen & Yifu Qiu & Xiaojin Cui & Y. P. Sharon Goh & Julia Mwangi & Tovo David & Lata Mukundan & Frank Brombacher & Richard M. Locksley & Ajay Chawla, 2011. "Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis," Nature, Nature, vol. 480(7375), pages 104-108, December.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Suyang Wu & Chen Qiu & Jiahao Ni & Wenli Guo & Jiyuan Song & Xingyin Yang & Yulin Sun & Yanjun Chen & Yunxia Zhu & Xiaoai Chang & Peng Sun & Chunxia Wang & Kai Li & Xiao Han, 2024. "M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Natasha M Girgis & Uma Mahesh Gundra & Lauren N Ward & Mynthia Cabrera & Ute Frevert & P'ng Loke, 2014. "Ly6Chigh Monocytes Become Alternatively Activated Macrophages in Schistosome Granulomas with Help from CD4+ Cells," PLOS Pathogens, Public Library of Science, vol. 10(6), pages 1-13, June.
    2. Xian Zhang & Songyuan Luo & Minjie Wang & Qiongqiong Cao & Zhixin Zhang & Qin Huang & Jie Li & Zhiyong Deng & Tianxiao Liu & Cong-Lin Liu & Mathilde Meppen & Amelie Vromman & Richard A. Flavell & Gökh, 2022. "Differential IL18 signaling via IL18 receptor and Na-Cl co-transporter discriminating thermogenesis and glucose metabolism regulation," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    3. Suyang Wu & Chen Qiu & Jiahao Ni & Wenli Guo & Jiyuan Song & Xingyin Yang & Yulin Sun & Yanjun Chen & Yunxia Zhu & Xiaoai Chang & Peng Sun & Chunxia Wang & Kai Li & Xiao Han, 2024. "M2 macrophages independently promote beige adipogenesis via blocking adipocyte Ets1," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    4. Jing Yan & Yuemei Zhang & Hairong Yu & Yicen Zong & Daixi Wang & Jiangfei Zheng & Li Jin & Xiangtian Yu & Caizhi Liu & Yi Zhang & Feng Jiang & Rong Zhang & Xiangnan Fang & Ting Xu & Mingyu Li & Jianzh, 2022. "GPSM1 impairs metabolic homeostasis by controlling a pro-inflammatory pathway in macrophages," Nature Communications, Nature, vol. 13(1), pages 1-22, December.
    5. Shaojian Lin & Anke Zhang & Ling Yuan & Yufan Wang & Chuan Zhang & Junkun Jiang & Houshi Xu & Huiwen Yuan & Hui Yao & Qianying Zhang & Yong Zhang & Meiqing Lou & Ping Wang & Zhen-Ning Zhang & Bing Lua, 2022. "Targeting parvalbumin promotes M2 macrophage polarization and energy expenditure in mice," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-022-35683-7. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.